| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Although influenza is a self-limited disease, patients are complicated with acute respiratory distress syndrome (ARDS), encephalopathy, myocarditis symptoms and may die in some cases. Using pathological and molecular biological methods, we have examined autopsied tissues with influenza virus to find two pathological mechanisms of ARDS. One mechanism involves influenza virus clone that replicates well in alveolar epithelial cells. The patients develop viral pneumonia complicated with ARDS of pulmonary origin, which then leads to respiratory failure and the death of patients. The other mechanism involves infection-induced excessive immune responses. This then develops systemic inflammatory response syndrome (SIRS) concurrently with ARDS, and causes multiple organ failures. Furthermore, higher expression levels of inflammatory mediators were observed in brain tissues with influenza encephalopathy.
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