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Role of aPKC-IL6 pathway, especially in prostatic and berast cancers

Research Project

Project/Area Number 26460456
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Human pathology
Research InstitutionTokyo Women's Medical University

Principal Investigator

NAGASHIMA Yoji  東京女子医科大学, 医学部, 教授 (10217995)

Co-Investigator(Kenkyū-buntansha) 秋本 和憲  東京理科大学, 薬学部生命創薬科学科, 准教授 (70285104)
Co-Investigator(Renkei-kenkyūsha) UEMURA Hiroji (ICHIKAWA Yasushi)  横浜市立大学, 附属病院, 教授 (70254208)
ISHIGURO Hitoshi  横浜市立大学, 医学部, 客員准教授 (00381666)
NAKAIGAWA Noboru  横浜市立大学, 大学院医学研究科, 准教授 (00237207)
AOKI Ichiro  横浜市立大学, 大学院医学研究科, 教授 (00184028)
OHASHI Ken-ichi  横浜市立大学, 大学院医学研究科, 教授 (40231203)
Research Collaborator IZUMISAWA Yuhsuke  横浜市立大学, 大学院生
MIZUSHIMA Taichi  横浜市立大学, 大学院生
KAWASHIMA Masato  横浜市立大学, 技術吏員
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
KeywordsaPKCλ/ι / 子宮頸癌 / CIN / 前立腺癌 / 腫瘍化 / 乳癌 / GLOI / Cancer / Immunohistochemistry / aPKC / 細胞極性 / 免疫組織化学 / HPV / LST
Outline of Final Research Achievements

Although aPKClambda/iota (aPKC)is a cell polarity-regulating factor, it has been known to be highly expressed in various cancer cells. We aimed to elucidates the roles of aPKC in development and progression of cancers. In this research, we demonstrated the facts as follows; 1) aPKC is highly expressed in uterine cervical cancer and its precursor, cervical intraepithelial neoplasia (CIN). Additionally, aPKC shows nuclear accumulation along with progression. 2) Cultured normal prostatic cells showed increased proliferation and motility, when aPKC gene is transfected, demonstrating that aPKC has a role in early stage of prostatic carcinogenesis. 3) Breast cancers coexpressiong aPKC, its binding protein p62 and glyoxalase I (GLOI) shows more unfavorable. Combined treatment of inhibitors of aPKC and GLOI effectively suppressed growth of co-expressing breast cancer cells in vitro. These indicated relationship between aPKC signaling and glucose metabolism in breast cancer.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (63 results)

All 2017 2016 2015 2014 Other

All Journal Article (36 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 34 results,  Open Access: 35 results,  Acknowledgement Compliant: 8 results) Presentation (19 results) (of which Invited: 1 results) Book (5 results) Remarks (3 results)

  • [Journal Article] Synchronous and Bilateral Oncocytic Carcinoma of the Breast: A case report and review of the literature.2017

    • Author(s)
      Itagaki H, Yamamoto T, Hiroi A, Kawanishi K, Noguchi E, Ohuchi T, Kamio T, Kameoka S, Oda H, Nagashima Y
    • Journal Title

      Oncol Lett

      Volume: 印刷中

    • Related Report
      2016 Annual Research Report
    • Open Access
  • [Journal Article] A case of gastrojejunocolic fistula with steatohepatitis.2017

    • Author(s)
      Omori T, Tokushige K, Kinoshita F, Ito A, Taniai M, Taneichi M, Iizuka B, Itabashi M, Nagashima Y, Yamamoto M, Nakamura S, Hashimoto E
    • Journal Title

      Clin J Gastroenterol

      Volume: 印刷中

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Xp11.2/TFE3 translocation associated renal cell carcinoma with multilocular cystic structures in an elderly patient. A case report.2017

    • Author(s)
      Sawazumi T, Kato I, Tanaka M, Tanaka Y, Yamanaka S, Kuroda N, Yao M, Nagashima Y, Ohashi K
    • Journal Title

      Int J Exp Clin Pathol

      Volume: 印刷中

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Limited benefit of targeted molecular therapy for inferior vena cava thrombus associated with renal cell carcinoma.2017

    • Author(s)
      Fukuda H, Kondo T, Takagi T, Iizuka J, Nagashima Y, Tanabe K
    • Journal Title

      Int J Clin Oncol

      Volume: 印刷中

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Well-differentiated adenocarcinoma associated with ulcerative colitis.2017

    • Author(s)
      Yamamoto T, Hiroi A, Itagaki H, Kato Y, Iizuka B, Itabashi M, Shibata N, Nagashima Y
    • Journal Title

      SAGE Open Medical Case Reports

      Volume: 印刷中

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pemafibrate, a novel selective peroxisome proliferator-activated receptor alpha modulator, improves the pathogenesis in a rodent model of nonalcoholic steatohepatitis.2017

    • Author(s)
      Honda Y, Kessoku T, Ogawa Y, Tomeno W, Imajo K, Fujita K, Yoneda M, Takizawa T, Saito S, Nagashima Y, Nakajima A
    • Journal Title

      Sci Rep

      Volume: 14

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lymphoepithelioma-like carcinoma of the upper urinary tract.2017

    • Author(s)
      Lopez-Beltran A, Paner G, Blanca A, Montironi R, Tsuzuki T, Nagashima Y, Chuang S-S, Win KT, Madruga L, Raspollini MR, Cheng L
    • Journal Title

      Virchows Archiv

      Volume: 印刷中

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Gorlin syndrome with an ovarian leiomyoma associated with a PTCH1 second hit2016

    • Author(s)
      Akizawa, Y., Miyashita, T., Sasaki, R., Nagata, R., Aoki, R., Ishitani, K., Nagashima, Y., Matsui, H., Saito, K
    • Journal Title

      Am J Med A

      Volume: 170 Issue: 4 Pages: 1029-1034

    • DOI

      10.1002/ajmg.a.37517

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genetic, epidemiologic and clinicopathologic studies of Japanese Asian patients with Birt-Hogg-Dube syndrome.2016

    • Author(s)
      Furuya M, Yao M, Tanaka R, Nagashima Y, Kuroda N, Hasumi H, Baba M, Matsushima J, Nomura F, Nakatani Y
    • Journal Title

      Clinical Genetics

      Volume: 90 Issue: 5 Pages: 403-412

    • DOI

      10.1111/cge.12807

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Establishment and characterization of BHD-F59RSVT, an immortalized cell line derived from a renal cell carcinoma in a patient with Birt-Hogg-Dube syndrome.2016

    • Author(s)
      Furuya M, Hasumi H, Baba M, Tanaka R, Iribe Y, Onishi T, Nagashima Y, Nakatani, Isono Y, Yao M
    • Journal Title

      Lab Invest

      Volume: -

    • Related Report
      2016 Annual Research Report
    • Open Access / Acknowledgement Compliant
  • [Journal Article] Flow cytometric analysis of ovarian cancer ascites: Response of mesothelial cells and macrophages to cancer.2016

    • Author(s)
      Hashimoto K, Honda K, Matsui H, Nagashima Y, Oda H
    • Journal Title

      Anticancer Res

      Volume: 36 Pages: 3579-3584

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Resveratrol ameliorates fibrosis and inflammation in a mouse model of nonalcoholic steatohepatitis.2016

    • Author(s)
      Kessoku T, Imajo K, Honda Y, et al.
    • Journal Title

      Sci Rep

      Volume: 25 Issue: 1 Pages: 22251-22251

    • DOI

      10.1038/srep22251

    • NAID

      120005749754

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Aberrant Expression of the Cell Polarity Regulator aPKCλ/ι is Associated With Disease Progression in Cer2016

    • Author(s)
      Mizushima T, Asai-Sato M, Akimoto K, Nagashima Y, Taguri M, Sasaki K, Nakaya MA, Asano R, Tokinaga A, Kiyono T, Hirahara F, Ohno S, Miyagi E.
    • Journal Title

      Int J Gynecol Pathol.

      Volume: 35 Issue: 2 Pages: 106-17

    • DOI

      10.1097/pgp.0000000000000228

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Caerulein-induced pancreatitis augments the expression and phosphorylation of collapsin response mediator protein 4.2016

    • Author(s)
      Sato S, Nakamura F, Hiroshima Y, Nagashima Y, Kato I, Yamashita N, Goshima Y, Endo I
    • Journal Title

      J Hepatobiliary Pancreat Sci

      Volume: 23 Issue: 7 Pages: 422-431

    • DOI

      10.1002/jhbp.361

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Proliferative glomerulonephritis with monoclonal immunoglobulin G deposits complicated by immunoglobulin A nephropathy in the renal allograft.2016

    • Author(s)
      Sawada A, Kawanishi K, Horita S, Koike J, Honda K, Ochi A, Komoda M, Tanaka Y, Unagami K, Okumi M, Shimizu T, Ishida H, Tanabe K, Nagashima Y, Nitta K
    • Journal Title

      Nephrology (Carlton)

      Volume: 21 Issue: S1 Pages: 48-52

    • DOI

      10.1111/nep.12775

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Review of renal anastomosing hemangioma with focus on clinical and pathological aspects.2016

    • Author(s)
      Kuroda N, Ohe C, Deepika S, Yorita K, Mikami S, Furuya M, Nagashima Y, Hes O, Michal M, Amin MB
    • Journal Title

      Pol J Pathol

      Volume: 67 Pages: 97-101

    • DOI

      10.5114/pjp.2016.61443

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Recent advances in renal cell carcinoma from a pathological point of view.2016

    • Author(s)
      Mikami S, Oya M, Mizuno R, Kosaka T, Ishida M, Kuroda N, Nagashima Y, Katsube K, Okada Y.
    • Journal Title

      Pathol Int.

      Volume: 66 Issue: 9 Pages: 481-90

    • DOI

      10.1111/pin.12433

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A preliminary study into the significance of intrarenal reflux in BK virus nephropathy after kidney transplantation.2016

    • Author(s)
      Kawanishi K, Honda, K, Koike J, Hattori M, Fuchinoue S, Tanabe K, Oda H, Nagashima Y
    • Journal Title

      Transplantation Direct

      Volume: 2 Issue: 2 Pages: 64-64

    • DOI

      10.1097/txd.0000000000000575

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Aberrant expression of erythropoietin in uterine leiomyoma: implications in tumor growth2015

    • Author(s)
      Ryoko Asano, Mikiko Asai-Sato, Yohei Miyagi, Taichi Mizushima, Makiko Koyama-Sato, Yoji Nagashima, Masataka Taguri, Hideya Sakakibara, Fumiki Hirahara, Etsuko Miyagi
    • Journal Title

      American Journal of Obstetrics and Gynecology

      Volume: 212 Issue: 2 Pages: 1-9

    • DOI

      10.1016/j.ajog.2015.02.016

    • Related Report
      2015 Research-status Report 2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Distinctive Expression Patterns of GPNMB and Folliculin in Renal Tumors in Patients with Birt-Hogg-Dube Syndrome.2015

    • Author(s)
      Furuya M, Hong SB, Tanaka R, Kuroda N, Nagashima Y, Nagahama K, Suyama T, Yao M, Nakatani Y
    • Journal Title

      Cancer Sci

      Volume: 106 Issue: 3 Pages: 315-323

    • DOI

      10.1111/cas.12601

    • Related Report
      2015 Research-status Report 2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Suppressed rate of carcinogenesis and decreases in tumour volume and lung metastasis in CXCL14/BRAK transgenic mice.2015

    • Author(s)
      Hata R, Izukuri K, Kato Y, Sasaki S, Mukaida N, Maehata Y, Miyamoto C, Akasaka T, Yang X, Nagashima Y, Takeda K, Kiyono T, Taniguchi M.
    • Journal Title

      Scientific Reports

      Volume: 5 Issue: 1 Pages: 9083-9083

    • DOI

      10.1038/srep09083

    • Related Report
      2015 Research-status Report 2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Immunohistochemical Characterization of Renal Tumors in Patients with Birt-Hogg-Dube Syndrome2015

    • Author(s)
      Iribe Y, Kuroda N, Nagashima Y, Yao M, Tanaka R, Gotoda H, Kawakami F, Imamura Y, Nakamura Y, Ando M, Araki A, Matsushima J, Nakatani Y, Furuya M
    • Journal Title

      . Pathol Int

      Volume: 65 Issue: 3 Pages: 126-132

    • DOI

      10.1111/pin.12254

    • Related Report
      2015 Research-status Report 2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Atypical hemolytic uremic syndrome diagnosed four years after ABO-incompatible kidney transplantation.2015

    • Author(s)
      Kawaguchi K, Kawanishi K, Sato M, Itabashi M, Fujii A, Kanetsuna Y, Huchinoue S, Ohashi R, Koike J, Honda K, Nagashima Y, Nitta K
    • Journal Title

      Nephrology (Carlton)

      Volume: 20 Issue: S2 Pages: 61-65

    • DOI

      10.1111/nep.12465

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Fat-poor angiomyolipoma with cyst-like changes mimicking a cystic renal cell carcinoma: a case report.2015

    • Author(s)
      Kobari Y, Takagi T, Kondo T, Tachibana H, Iida S, Nishina Y, Omae K, Morita S, Yamamoto T, Iizuka J, Nagashima Y, Tanabe K
    • Journal Title

      World J Surg Oncol

      Volume: 13 Issue: 1 Pages: 251-251

    • DOI

      10.1186/s12957-015-0677-4

    • NAID

      120007163721

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Phosphatidylinositol inhibits respiratory syncytial virus infection.2015

    • Author(s)
      Numata M, Kandasamy P, Nagashima Y, Fickes R, Murphy RC, Voelker DR.
    • Journal Title

      J Lipid Res

      Volume: 56 Issue: 3 Pages: 578-587

    • DOI

      10.1194/jlr.m055723

    • Related Report
      2015 Research-status Report 2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Deficiency of eNOS exacerbates early-stage NAFLD pathogenesis by changing the fat distribution.2015

    • Author(s)
      Nozaki Y, Fujita K, Wada K, Yoneda M, Shinohara Y, Imajo K, Ogawa Y, Kessoku T, Nakamuta M, Saito S, Masaki N, Nagashima Y, Terauchi Y, Nakajima A.
    • Journal Title

      BMC Gastroenterol

      Volume: 17 Issue: 1 Pages: 177-177

    • DOI

      10.1186/s12876-015-0409-9

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mucinous cystadenoma of a horseshoe kidney: A case report and literature review.2015

    • Author(s)
      Mitome T, Yao M, Udaka N, Fusayasu S, Izumi K, Osaka K, Hayashi N, Nakaigawa N, Nagashima Y, Kubota Y.
    • Journal Title

      Can Urol Assoc J

      Volume: 9 Issue: 1-2 Pages: 30-32

    • DOI

      10.5489/cuaj.2211

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] LDL-migration index (LDL-MI), an indicator of small dense low-density lipoprotein (sdLDL), is higher in non-alcoholic steatohepatitis than in non-alcoholic fatty liver: a multicenter cross-sectional study.2014

    • Author(s)
      Imajo K, Hyogo H, Yoneda M, Honda Y, Kessoku T, Tomeno W, Ogawa Y, Taguri M, Mawatari H, Nozaki Y, Fujita K, Kirikoshi H, Saito S, Sumida Y, Ono M, Wada K, Nakajima A, Eguchi Y.
    • Journal Title

      PLoS One

      Volume: 26;9(12) Issue: 1

    • DOI

      10.1186/s12876-015-0269-3

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Clear cell papillary renal cell carcinoma: a review.2014

    • Author(s)
      Kuroda N, Ohe C, Kawakami F, Mikami S, Furuya M, Matsuura K, Moriyama M, Nagashima Y, Zhou M, Petersson F, López JI, Hes O, Michal M, Amin MB.
    • Journal Title

      Int J Clin Exp Pathol

      Volume: 7 Pages: 7312-7318

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Molecular and drug sensitivity studies in xenograft and ex vivo tumor cell culture to identify agents for therapy.2014

    • Author(s)
      Ruan Y, Kovalchuk A, Jayanthan A, Lun X, Nagashima Y, Kovalchuk O, Wright JR Jr, Pinto A, Kirton A, Anderson R, Narendran A.
    • Journal Title

      Neuro Oncol

      Volume: -

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 腎腫瘍の病理診断 up date2014

    • Author(s)
      長嶋洋治、青木一郎、近藤恵一、中井川昇、岸田健、宮城洋平、矢尾正祐
    • Journal Title

      臨床病理

      Volume: 62 Pages: 568-577

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Colorectal laterally spreading tumors show characteristic expression of cell polarity factors, including atypical protein kinase C λ/ι, E-cadherin, beta-catenin and basement membrane component.2014

    • Author(s)
      chikawa Y, Nagashima Y, Morioka K, Akimoto K, Kojima Y, Ishikawa T, Goto A, Kobayashi N, Watanabe K, Ota M, Fujii S, Kawamata M, Takagawa R, Kunizaki C, Takahashi H, Nakajima A, Maeda S, Shimada H, Inayama Y, Ohno S, Endo I.
    • Journal Title

      Oncol Lett

      Volume: 8 Pages: 977-984

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Solitary fibrous tumor of the kidney with focus on clinical and pathobiological aspects.2014

    • Author(s)
      Kuroda N, Ohe C, Sakaida N, Uemura Y, Inoue K, Nagashima Y, Hes O, Michal M.
    • Journal Title

      Int J Clin Exp Pathol

      Volume: 7 Pages: 2737-2742

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Proteomic analysis of proteins related to prognosis of lung adenocarcinoma.2014

    • Author(s)
      Okayama A, Miyagi Y, Oshita F, Nishi M, Nakamura Y, Nagashima Y, Akimoto K, Ryo A, Hirano H.
    • Journal Title

      J Proteome Res

      Volume: 13 Issue: 11 Pages: 4686-464

    • DOI

      10.1021/pr4012969

    • NAID

      130005454677

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Tumor signatures of PTHLH overexpression, high serum calcium, and poor prognosis were observed exclusively in clear cell but not non clear cell renal carcinomas2014

    • Author(s)
      Yao M, Nagashima Y et al
    • Journal Title

      Cancer Med

      Volume: (in press) Issue: 4 Pages: 845-854

    • DOI

      10.1002/cam4.270

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Establishment of successively transplantable rabbit VX2 cancer cells that express enhanced green fluorescent protein2014

    • Author(s)
      Oshiro H, Fukumura H, Nagahama K, Sato I, Sugiura K, Iobe H, Okiyama E, Nagao T, Nagashima Y, Aoki I, Yamanaka S, Murakami A, Maegawa J, Chishima T, Ichikawa Y, Ishikawa Y, Nagai T, Nomura M, Ohashi K and Okudela K
    • Journal Title

      Med Mol Morphol

      Volume: 印刷中 Issue: 1 Pages: 13-23

    • DOI

      10.1007/s00795-014-0071-2

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 日本人に発生したCoccidioides immitis耳感染症の一例2016

    • Author(s)
      長嶋洋治、佐藤えみり、菊池賢、野中学、吉原俊雄、山本智子
    • Organizer
      第62回日本病理学会秋期総会
    • Place of Presentation
      金沢文化ホール(石川県金沢市)
    • Year and Date
      2016-11-10
    • Related Report
      2016 Annual Research Report
  • [Presentation] Birt-Hogg-Dube症候群における腎癌の分子病理学的検討2016

    • Author(s)
      古屋充子、入部康弘、蓮見壽史、馬場理也、長嶋洋治、加藤生真、中谷行雄,矢尾正祐
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-10-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] 腰髄に転移した atypical teratoid/rhabdoid tumor の髄液細胞診の1例2016

    • Author(s)
      橋本哲也, 村上佳織, 清水絢子, 高橋伸治, 野並裕司, 金室俊子, 藍原康雄, 山本智子, 澤田達男, 長嶋洋治
    • Organizer
      第57回日本臨床細胞学会春期大会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-05-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] 散発性腎hybrid oncocytic/ chromophobe tumor( HOCT)の2例2016

    • Author(s)
      長嶋洋治、澤田杏理、小針悠希、板垣裕子、高木敏男、近藤恒徳、山本智子、黒田直人
    • Organizer
      第105回日本病理学会総会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2016-05-11
    • Related Report
      2016 Annual Research Report
  • [Presentation] 腎腫瘍針生検の病理診断:ガイドラインの作成2016

    • Author(s)
      長嶋洋治、廣井敦子、板垣裕子、鬼塚裕美、澤田杏理、山本智子、近藤恒徳、森田賢、澤田達男
    • Organizer
      第105回日本病理学会総会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2016-05-11
    • Related Report
      2016 Annual Research Report
  • [Presentation] ヒト乳癌におけるAtypical protein kinase C (aPKC)λ/ιと糖代謝機構との関連2016

    • Author(s)
      本村瞳, 片山鈴花, 多森翔馬, 松村将史, 柳川拓哉, 和氣由布子, 高澤涼子, 田沼靖一, 宮城洋平, 長嶋洋治, 今井美沙, 佐藤圭子, 秋本和憲
    • Organizer
      第136回日本薬学会年会
    • Place of Presentation
      パシフィコ横浜(横浜市西区)
    • Year and Date
      2016-03-26
    • Related Report
      2015 Research-status Report
  • [Presentation] 腎腫瘍の病理:画像診断に当たり知っておくべきこと2015

    • Author(s)
      長嶋洋治
    • Organizer
      第42回泌尿器画像診断研究会
    • Place of Presentation
      東京慈恵会医科大学(東京都港区)
    • Year and Date
      2015-10-24
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 液状化検体細胞診(LBC)における診断精度と内膜異型細胞(ATEC)の細胞像の検討2015

    • Author(s)
      花田 梓,平井康夫,木村祐子,岡田薫子,広兼春美,徳田美由紀,深川富美子,藏本吾郎,秋澤叔香,木原真紀,石谷 健,長嶋洋治,則松良明,矢納研二,松井英雄
    • Organizer
      第54回日本臨床細胞学会秋期大会
    • Place of Presentation
      名古屋国際会議場(名古屋市熱田区)
    • Year and Date
      2015-10-22
    • Related Report
      2015 Research-status Report
  • [Presentation] 術中迅速診断時に捺印細胞診を行った卵巣未熟奇形腫4例の細胞像2015

    • Author(s)
      村上佳織、金室俊子、野並裕司、高橋伸治、粉川彩、清水絢子、橋本哲也、富所貴美子、村松文章、廣井敦子、山本智子、澤田達男、長嶋洋治
    • Organizer
      第54回日本臨床細胞学会秋期大会
    • Place of Presentation
      名古屋国際会議場(名古屋市熱田区)
    • Year and Date
      2015-10-21
    • Related Report
      2015 Research-status Report
  • [Presentation] Establishment of algorism in needle biopsy of renal neoplasms2015

    • Author(s)
      長嶋洋治、近藤恒徳、矢尾正祐、青木一郎、大橋健一
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(名古屋市熱田区)
    • Year and Date
      2015-10-10
    • Related Report
      2015 Research-status Report
  • [Presentation] Development of Lung Tumors in Patients with Birt-Hogg-Dube Syndrome: A Pathological Study2015

    • Author(s)
      中谷行雄、奥寺康司、入部康弘、矢尾正祐、蓮見壽史、長嶋洋治、馬場理也、野村文夫、古屋充子
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(名古屋市熱田区)
    • Year and Date
      2015-10-09
    • Related Report
      2015 Research-status Report
  • [Presentation] Analysis of Somatic Mutations and Chromosome in Renal Cell Carcinomas in Patients with Birt-Hogg-Dube Syndrome2015

    • Author(s)
      入部康弘、矢尾正祐、蓮見壽史、長嶋洋治、馬場理也、野村文夫、中谷行雄、古屋充子
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(名古屋市熱田区)
    • Year and Date
      2015-10-09
    • Related Report
      2015 Research-status Report
  • [Presentation] Clarification of the molecular mechanism for cancer development in Xp11.2 translocation renal cell carcinoma2015

    • Author(s)
      馬場理也、黄瑩、蓮見壽史、矢尾正祐、長嶋洋治、古屋充子、尾池雄一、江藤正俊、Laura_S Schmidt、W Marston Linehan
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(名古屋市熱田区)
    • Year and Date
      2015-10-08
    • Related Report
      2015 Research-status Report
  • [Presentation] Epidemiology and Pathology of Renal Cell Carcinomas andOther Neoplasms in 100 Families with Birt-Hogg-Dube Syndrome2015

    • Author(s)
      古屋充子、入部康弘、矢尾正祐、蓮見壽史、長嶋洋治、馬場理也、野村文夫、中谷行雄
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(名古屋市熱田区)
    • Year and Date
      2015-10-08
    • Related Report
      2015 Research-status Report
  • [Presentation] 来週から役立つ腎腫瘍の病理診断2015

    • Author(s)
      長嶋洋治
    • Organizer
      第169回日本病理学会北海道支部会標本交見会 特別講演
    • Place of Presentation
      JA札幌厚生病院(北海道・札幌市)
    • Year and Date
      2015-01-24
    • Related Report
      2014 Research-status Report
  • [Presentation] Categorization of renal tumors for pathological diagnosis based on experience of 500 cases.2014

    • Author(s)
      長嶋 洋治、矢尾 正祐、青木 一郎
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2014-10-08 – 2014-10-10
    • Related Report
      2014 Research-status Report
  • [Presentation] 腎癌の病理診断:明日から役立つ腎腫瘍の実戦的診断2014

    • Author(s)
      長嶋洋治
    • Organizer
      45th Congress of Japanese Society of Renal Cancer and 1st East Asia Kidney Cancer Symposium
    • Place of Presentation
      品川インターシティホール(東京都・品川区)
    • Year and Date
      2014-07-20
    • Related Report
      2014 Research-status Report
  • [Presentation] 明日から使える腎腫瘍の診断-組織型と落とし穴-2014

    • Author(s)
      長嶋洋治
    • Organizer
      第103回日本病理学会総会 病理診断系統講習会
    • Place of Presentation
      広島国際会議場(広島県・広島市)
    • Year and Date
      2014-04-25 – 2014-04-27
    • Related Report
      2014 Research-status Report
  • [Presentation] 腎腫瘍診断のための免疫染色~多様な組織型分類,治療戦略にも応用できる免疫染色~2014

    • Author(s)
      大江知里,黒田直人,長嶋洋治
    • Organizer
      第103回日本病理学会総会 コンパニオンミーティング
    • Place of Presentation
      広島国際会議場(広島県・広島市)
    • Year and Date
      2014-04-25 – 2014-04-27
    • Related Report
      2014 Research-status Report
  • [Book] 小田義直、坂本亨宇、深山正久、松野吉宏、森永正二郎、森谷卓也(編):組織病理アトラス(第6版)2015

    • Author(s)
      長嶋洋治
    • Total Pages
      543
    • Publisher
      文光堂
    • Related Report
      2015 Research-status Report
  • [Book] 青笹克之(編) 解明病理学 病気のメカニズムを解く(第2版第3刷)2015

    • Author(s)
      長嶋洋治
    • Total Pages
      831
    • Publisher
      医歯薬出版
    • Related Report
      2014 Research-status Report
  • [Book] 河原栄、中谷行雄(監訳) ルービン「カラー 基本病理学」(第5版)2015

    • Author(s)
      長嶋洋治
    • Total Pages
      757
    • Publisher
      西村書店
    • Related Report
      2014 Research-status Report
  • [Book] 下正宗、長嶋洋治(編) 正常画像と比べてわかる病理アトラス(改訂版)2015

    • Author(s)
      長嶋洋治
    • Total Pages
      341
    • Publisher
      羊土社
    • Related Report
      2014 Research-status Report
  • [Book] 豊國伸哉、高橋雅英 (監訳) ロビンス「基礎病理学」(原書9版)2014

    • Author(s)
      長嶋洋治
    • Total Pages
      1085
    • Publisher
      丸善出版
    • Related Report
      2014 Research-status Report
  • [Remarks] 東京女子医科大学病理診断科

    • URL

      http://www.twmu.ac.jp/univ/medical/subject/detail.php?id=02030

    • Related Report
      2016 Annual Research Report
  • [Remarks] 長嶋洋治業績

    • URL

      http://gyoseki.twmu.ac.jp/twmhp/KgApp?kyoinId=ymiygsyoggs

    • Related Report
      2016 Annual Research Report
  • [Remarks] 東京女子医科大学 教員研究業績データベース

    • URL

      http://gyoseki.twmu.ac.jp/twmhp/KgApp?kyoinId=ymiygsyoggs

    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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