Epidemiological survey and immunological and molecular pathological study of hepatocellular adenoma in Japan

• Project/Area Number: 26460461
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Human pathology
• Research Institution: Nihon University
• Principal Investigator: SUGITANI Masahiko 日本大学, 医学部, 教授 (40187654)
• Co-Investigator(Kenkyū-buntansha): 中野 雅行 横浜市立大学, 附属市民総合医療センター, その他 (00092073) ; 江角 真理子 日本大学, 医学部, 教授 (10147019) ; 小川 眞広 日本大学, 医学部, 講師 (20318405) ; 山崎 慎太郎 日本大学, 医学部, 助教 (20409014) ; 絹川 典子 日本大学, 医学部, 講師 (90224998)
• Co-Investigator(Renkei-kenkyūsha): TAKAYAMA Tadatoshi 日本大学, 医学部, 教授 (30280944) ; KANEITA Yoshitaka 大分大学, 医学部, 教授 (40366571)
• Research Collaborator: IZU Asami
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 肝細胞腺腫 / WHO分類 / 疫学調査 / 病理診断 / 臨床病理学的研究 / 免疫組織化学的研究 / 分子病理学的研究 / アンケート全国調査 / 亜型分類 / 肝細胞癌 / 免疫組織化学 / 遺伝子検索 / 発生頻度 / subtype / アンケート調査

Outline of Final Research Achievements

Hepatocellular adenoma (HCA) is hepatic benign neoplasm, which has been estimated to have a lower prevalence in Japan than in Western countries, though definitive data are as yet lacking. Importance of HCA research is increasing because that histological feature is difficult in differentiating between HCA and well differentiated hepatocellular carcinoma and one subtype of HCA has potentiality to malignant transformation. We endeavored to ascertain the HCA prevalence in Japan, in this study. We sent a questionnaire survey to hospitals, 402 in total, conducting large numbers of liver operations. The response rate was approximately 80%. In the replies, experience of HCA case was approximately 30%. Definitive HCA cases in surgically resected liver was 117, in which gender, age and clinical background was examined. Subtype was immunohsitochemically determined. In some cases, genetic abnormalities were investigated.

Research Products

• [Journal Article] Characteristics of Hepatic Schwannoma Presenting as an Unusual Multi-cystic Mass on Gadoxetic Acid Disodium-enhanced MR Imaging (2018)
  • Author(s): Haradome H, Woo J, Nakayama H, Watanabe HN, Ogawa M, Moriyama M, Sugitani M, Takayama T, Abe O
  • Journal Title: Magnetic Resonance in Medical Sciences Volume: 17 Issue: 1 Pages: 95-99
  • DOI: 10.2463/mrms.cr.2016-0101
  • NAID: 130006306857
  • ISSN: 1347-3182, 1880-2206
  • Peer Reviewed
• [Journal Article] 肝細胞腺腫 (2017)
  • Author(s): 杉谷雅彦、伊豆麻未、高山忠利、中野雅行
  • Journal Title: 病理と臨床 Volume: 35 Pages: 333-338
  • Acknowledgement Compliant
• [Journal Article] Transglutaminase 2 is upregulated in primary hepatocellular carcinoma with early recurrence as determined by proteomic profiles (2017)
  • Author(s): Yamaguchi H, Kuroda K, Sugitani M, Takayama T, Hasegawa K, Esumi M
  • Journal Title: Int J Oncol Volume: Feb 13 Pages: 1749-1759
  • Peer Reviewed
• [Journal Article] Intrahepatic cholangiocarcinoma (2017)
  • Author(s): Nakano M, Ariizumi SI, Yamamoto M
  • Journal Title: Semin Diagn Pathol. Volume: 34(2) Issue: 2 Pages: 160-166
  • DOI: 10.1053/j.semdp.2016.12.012
  • Peer Reviewed
• [Journal Article] Central vascular structures as a characteristic finding of regenerative nodules using hepatobiliary phase gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid-enhanced MRI and arterial dominant phase contrast-enhanced US (2017)
  • Author(s): Sugimori K, Numata K, Okada M, Nihonmatsu H, Takebayashi S, Maeda S, Nakano M, Tanaka K
  • Journal Title: J Med Ultrason (2001) Volume: 44(1) Issue: 1 Pages: 89-100
  • DOI: 10.1007/s10396-016-0750-9
  • NAID: 130007650201
  • Peer Reviewed
• [Journal Article] Contrast-enhanced ultrasonographic findings of serum amyloid A-positive hepatocellular neoplasm: Does hepatocellular adenoma arise in cirrhotic liver? (2016)
  • Author(s): Kumagawa M, Matsumoto N, Watanabe Y, Hirayama M, Miura T, Nakagawara H, Ogawa M, Matsuoka S, Moriyama M, Takayama T, Sugitani M.
  • Journal Title: World J Hepatol Volume: 8(26) Issue: 26 Pages: 1110-1115
  • DOI: 10.4254/wjh.v8.i26.1110
  • Peer Reviewed
• [Journal Article] Focal Sinusoidal Obstruction Syndrome Caused by Oxaliplatin-Induced Chemotherapy: A Case Report (2016)
  • Author(s): Kawai T, Yamazaki S, Iwama A, Higaki T, Sugitani M, Takayama T
  • Journal Title: Hepat Mon Volume: 16(9) Issue: 9
  • DOI: 10.5812/hepatmon.37572
  • Peer Reviewed
• [Journal Article] Touch cytology smear of an inflammatory hepatocellular adenoma displaying an unusual pattern: A case report (2016)
  • Author(s): Kanda H, Furuta R, Motoi N, Suzuki N, Furuta N, Komatsu K, Sugiyama Y, Saiura A, Sugitani M, Ishikawa Y
  • Journal Title: Diagn Cytopathol. Volume: 44(12) Issue: 12 Pages: 1074-1077
  • DOI: 10.1002/dc.23541
  • Peer Reviewed
• [Journal Article] Natural history of nonenhancing lesions incidentally detected during the diagnosis of hepatocellular carcinoma (2016)
  • Author(s): Ebisawa K, Midorikawa Y, Higaki T, Nakayama H, Tsuji S, Nishimaki H, Haradome H, Abe O, Sugitani M, Moriyama M, Takayama T
  • Journal Title: Surgery Volume: 160(3) Issue: 3 Pages: 654-660
  • DOI: 10.1016/j.surg.2016.04.019
  • Peer Reviewed
• [Journal Article] Prediction of vascular invasion in hepatocellular carcinoma by next-generation des-r-carboxy prothrombin (2016)
  • Author(s): Kurokawa T, Yamazaki S, Mitsuka Y, Moriguchi M, Sugitani M, Takayama T
  • Journal Title: Br J Cancer Volume: 114(1) Pages: 423-423
  • Peer Reviewed
• [Journal Article] Analysis of infectious compolications and timing for emergency liver transplantation in autoimmune acute liver failure. (2016)
  • Author(s): K Fujiwara, S Yasui, Y Yonemitsu, M Arai, T Kanda, Y Fukuda, M Nakano, S Oda, O Yokosuka
  • Journal Title: J Hepatobiliary Pancreat Sci Volume: 23 Issue: 4 Pages: 212-219
  • DOI: 10.1002/jhbp.326
  • Peer Reviewed / Open Access
• [Journal Article] High level of persistent liver injury is one of clinical characteristics in treatment-naïve acute onset autoimmune hepatitis: experience in acommunity hospital (2016)
  • Author(s): K Fujiwara, Y Fukuda Y,K Seza, M Saito, S Yasui, M Nakano, O Yokosuka
  • Journal Title: J Hepatobiliary Pancreat Sci Volume: 23 Issue: 3 Pages: 174-180
  • DOI: 10.1002/jhbp.319
  • Peer Reviewed / Open Access
• [Journal Article] Morphophenotypic changes in human multistep hepatocarcinogenesis with translational implications. (2016)
  • Author(s): Sciarra A, Di Tommaso L, Nakano M, Destro A, Torzilli G, Donadon M, Maggioni M, Bosari S, Bulfamante G, Matsuda M, Fujii H, Ichikawa T, Morisaka H, Sano K, Ichikawa S, Roncalli M.
  • Journal Title: J Hepatol Volume: 64 Issue: 1 Pages: 87-93
  • DOI: 10.1016/j.jhep.2015.08.031
  • Peer Reviewed / Open Access
• [Journal Article] 高齢男性に発症した巨大肝細胞腺腫の１例 (2016)
  • Author(s): 工藤 宏樹、脊山 泰治、矢澤 徹、鹿股 宏之、谷 圭吾、蕨 雅大、高橋 正道、松岡 勇二郎、上山 俊介、中野 雅行、宮本 幸雄、梅北 信孝
  • Journal Title: Liver Cancer Volume: 22 Pages: 41-45
• [Journal Article] 腫瘍破裂を契機に診断された細胆管細胞癌と肝細胞癌との混合型肝癌の１症例 (2016)
  • Author(s): 濱野 美枝、中村 努、大石 英人、片桐 聡、鬼澤 俊輔、平井 栄一、飯野 高之、石井雅之、石田 猛志、向山 美々、毛利 俊彦、新井田 達雄、中野雅行
  • Journal Title: Liver Cancer Volume: 22 Pages: 81-86
• [Journal Article] HBV既往感染の肝硬変に多発した良性、悪性肝細胞腫瘍のHE, VB標本による簡易診断 (2016)
  • Author(s): 中野雅行、魚嶋 晴樹、金原 猛、増田 作栄、加古 眞
  • Journal Title: Liver Cancer Volume: 22 Pages: 75-79
• [Journal Article] Prediction of vascular invasion in hepatocellular carcinoma by next-generation des-r-carboxy prothrombin. (2016)
  • Author(s): Kurokawa T, Yamazaki S, Mitsuka Y, Moriguchi M, Sugitani M, Takayama T.
  • Journal Title: Br J Cancer Volume: 114 Issue: 1 Pages: 53-58
  • DOI: 10.1038/bjc.2015.423
  • Peer Reviewed / Open Access
• [Journal Article] A case of inflammatory hepatocellular adenoma displaying an unusual histological pattern (2015)
  • Author(s): Kanda H, Furuta R, Motoi N, Kakita T, Sugiura Y, Unno T, Matsueda K, Saiura A, Sugitani M, Ishikawa Y
  • Journal Title: Clin J Gastroenterol Volume: 8(6) Issue: 6 Pages: 426-34
  • DOI: 10.1007/s12328-015-0614-7
  • Peer Reviewed / Open Access
• [Journal Article] Severe and fulminant hepatitis of indeterminate etiology in a Japanese center. (2015)
  • Author(s): K Fujiwara, S Yasui, M Nakano, Y Yonemitsu, M Arai, T Kanda, Y Fukuda, S Oda, O Yokosuka
  • Journal Title: Hepatology Research Volume: 45 Issue: 10
  • DOI: 10.1111/hepr.12483
  • Peer Reviewed / Open Access
• [Journal Article] Automatic calculation and visualization of nuclear density in whole slid images of hepatic histological sections. (2015)
  • Author(s): A Nagase, M Takahashi, M Nakano
  • Journal Title: Bio-Mdeical Materials and Engineering Volume: 26 Issue: s1 Pages: S1335-S1344
  • DOI: 10.3233/bme-151431
  • Peer Reviewed / Open Access
• [Journal Article] Importance of the poor prognosis of severe and fulminant hepatitis in the early in an era of a highly aging society: Analysis in a Japanese center. (2015)
  • Author(s): K Fujiwara, S Yasui, Y Yonemitsu, M Arai, T Kanda, M Nakano, S Oda, O Yokosuka
  • Journal Title: Hepatology Research Volume: 45 Issue: 8 Pages: 863-871
  • DOI: 10.1111/hepr.12426
  • Peer Reviewed / Open Access
• [Journal Article] Sarcomatoid Hepatocellular Carcinoma with Spontaneous Intraperitoneal Bleeding (2015)
  • Author(s): Watanabe Y, Matsumoto N, Ogawa M, Moriyama M, Sugitani M.
  • Journal Title: Internal Medicine Volume: 54 Issue: 13 Pages: 1613-1617
  • DOI: 10.2169/internalmedicine.54.3523
  • NAID: 130005086455
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed / Open Access
• [Journal Article] Improving recognition of hepatic perivascular epithelioid cell tumor: Case report and literature review. (2015)
  • Author(s): Maebayashi T, Abe K, Aizawa T, Sakaguchi M, Ishibashi N, Abe O, Takayama T, Nakayama H, Matsuoka S, Nirei K, Nakamura H, Ogawa M, Sugitani M.
  • Journal Title: World J Gastroenterol Volume: 21 Issue: 17 Pages: 5432-5441
  • DOI: 10.3748/wjg.v21.i17.5432
  • Peer Reviewed / Open Access
• [Journal Article] Transmembrane serine protease TMPRSS2 activates hepatitis C virus infection. (2015)
  • Author(s): Esumi M, Ishibashi M, Yamaguchi H, Nakajima S, Tai Y, Kikuta S, Sugitani M, Takayama T, Tahara M, Takeda M, Wakita T
  • Journal Title: Hepatology Volume: 61(2) Issue: 2 Pages: 438-47
  • DOI: 10.1002/hep.27426
  • Peer Reviewed / Open Access
• [Journal Article] Pathological Evidence of the Cause of Spontaneous Regression in a Case of Resected Hepatocellular Carcinoma (2015)
  • Author(s): Matsuoka S, Tamura A, Moriyama M, Fujikawa H, Mimatsu K, Oida T, Sugitani M.
  • Journal Title: Internal Medicine Volume: 54 Issue: 1 Pages: 25-30
  • DOI: 10.2169/internalmedicine.54.2981
  • NAID: 130004902987
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed / Open Access
• [Journal Article] 肝細胞腺腫の疫学と背景因子：欧米との比較 (2014)
  • Author(s): 杉谷雅彦、羽野寛、八尾隆史、森下由紀雄、神田浩明、松本光司、林星舟、有泉俊一、山本雅一、中野雅行
  • Journal Title: 肝胆膵 Volume: 69 Pages: 691-694
• [Journal Article] 肝細胞腺腫の亜分類と形態 (2014)
  • Author(s): 中野雅行
  • Journal Title: 肝胆膵 Volume: 69 Pages: 703-709
• [Journal Article] 早期肝細胞癌と肝細胞腺腫が併存しその発生に関し示唆に富んだ１症例 (2014)
  • Author(s): 脊山泰治、中野雅行、谷澤徹、伊藤貴弘、谷圭吾、蕨雅大、高橋正道、松岡勇二郎、斎藤明子、宮本幸雄、梅北信孝
  • Journal Title: Liver Cancer Volume: 20 Pages: 65-70
• [Presentation] Survey of hepatocellular adenoma in Japan (2016)
  • Author(s): Masahiko Sugitani, Asami Izu, Noriko Kinukawa, Mariko Esumi, Masahiro Ogawa, Shintaro Yamazaki, Tadatoshi Takayama, Masayuki Nakano
  • Organizer: XXXI International Congress of the International Academy of Pathology
  • Place of Presentation: Cologne, Germany
  • Year and Date: 2016-09-25
  • Int'l Joint Research
• [Presentation] Genotype analysis of hepatocellular adenoma in Japan. (2015)
  • Author(s): Masahiko Sugitani, Asami Izu, Noriko Kinukawa, Masahiro Ogawa, Shintaro Yamazaki, Tadatoshi Takayama, Hiroshi Hano, Takashi Yao, Naoya Nakamura, Yukio Morishita, Hiroaki Kanda, Koshi Matsumoto, Seisyu Hayashi, Syun-ichi Ariizumi, Msakazu Yamamoto, Masayuki Nakano.
  • Organizer: International Liver Cancer Association’s 9th Annual Conference.
  • Place of Presentation: Paris, France
  • Year and Date: 2015-09-04
  • Int'l Joint Research
• [Presentation] Vascularization of hepatocellular adenomas and carcinomas by co-operation of portal tract. (2014)
  • Author(s): Ashley E. Stueck, Masayuki Nakano, I.R. Wanless.
  • Organizer: The 65th Annual Meeting of the American Association for the Study of Liver Diseases
  • Place of Presentation: Boston (USA)
  • Year and Date: 2014-11-07 – 2014-11-11
• [Presentation] 問題症例検討会CR1-4症例 (2014)
  • Author(s): 中村仁美、楡井和重、松岡俊一、森山光彦、山岸俊介、黒川智晴、蛯澤記代子、万本 潤、山崎慎太郎、森口正倫、緑川 泰、檜垣時夫、中山壽之、高山忠利、原留弘樹、阿部 修、杉谷雅彦
  • Organizer: 第50回日本肝癌研究会
  • Place of Presentation: 国立京都国際会館（京都府、京都市）
  • Year and Date: 2014-06-05 – 2014-06-06