| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Adult T cell leukemia / lymphoma (ATL) is a very poor prognostic peripheral T cell lymphoma with very strong invasivasion into tissues and consequent drug resistance. We found that ATL cells acquire "cancer stem cell-like propeties such as cell cycle arrest and apoptosis resistance by adhesion with normal epithelial cells (Am J Pathol, 2013). We think that this phenomenon leads to understanding not only of ATL but also the mechanism of drug resistance acquisition in malignant tumor which caused tissue invasion. In this study, in order to raise the universality of this phenomenon focusing on pancreatic cancer of intractable solid cancer, the mechanism of the development of cancer stem cell-like cells induced by adhesion to epithelial-like feeder cells. Finally, we aimed to establish a novel therapeutic concept capable of responding to a wide range of refractory cancers targeting "prevention of cancer stem cell development" induced by adhesion with normal epithelium.
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