Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Outline of Final Research Achievements |
Cancer initiating cells are resistant to anti-tumor therapies. In this study, we showed that ALDH-hi cells, which are considered as cancer initiating cells, are regulated by Nodal, and that ALDH-hi cells expressed S100A4 strongly. S100A4 is related to proliferation and invasion ability of uterine endometrial carcinoma, and S100A4-hi cases possessed "MELF" pattern. In addition, arginine synthetic enzyme was also upregulated in ALDH-hi cells. This enzyme epigenetically controlled mTOR-complex member, DEPTOR. These results suggested that cancer initiating cells are controlled by various factors, which are related to yield of heterogenous populations of tumors.
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