Regulation of heterogeneity of tumors from the viewpoint of cancer initiating cells
Project/Area Number |
26460470
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Experimental pathology
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Research Institution | Osaka University |
Principal Investigator |
Morii Eiichi 大阪大学, 医学系研究科, 教授 (10283772)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Keywords | 腫瘍幹細胞 / 多様性 / 制御因子 / 未熟性 / リンパ腫 |
Outline of Final Research Achievements |
Cancer initiating cells are resistant to anti-tumor therapies. In this study, we showed that ALDH-hi cells, which are considered as cancer initiating cells, are regulated by Nodal, and that ALDH-hi cells expressed S100A4 strongly. S100A4 is related to proliferation and invasion ability of uterine endometrial carcinoma, and S100A4-hi cases possessed "MELF" pattern. In addition, arginine synthetic enzyme was also upregulated in ALDH-hi cells. This enzyme epigenetically controlled mTOR-complex member, DEPTOR. These results suggested that cancer initiating cells are controlled by various factors, which are related to yield of heterogenous populations of tumors.
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] Argininosuccinate Synthase 1-Deficiency Enhances the Cell Sensitivity to Arginine through Decreased DEPTOR Expression in Endometrial Cancer.2017
Author(s)
Ohshima K, Nojima S, Tahara S, Kurashige M, Hori Y, Hagiwara K, Okuzaki D, Oki S, Wada N, Ikeda JI, Kanai Y, Morii E.
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Journal Title
Sci Rep.
Volume: 7
Pages: 45504-45504
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Similar protein expression profiles of ovarian and endometrial high-grade serous carcinomas.2016
Author(s)
Hiramatsu K, Yoshino K, Serada S, Yoshihara K, Hori Y, Fujimoto M, Matsuzaki S, Egawa-Takata T, Kobayashi E, Ueda Y, Morii E, Enomoto T, Naka T, Kimura T.
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Journal Title
Br J Cancer.
Volume: 114
Pages: 554-61
Related Report
Peer Reviewed
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[Presentation] 腫瘍幹細胞とニッチ2015
Author(s)
森井英一
Organizer
第16回日本毒性病理学会教育セミナー
Place of Presentation
大阪市立大学
Year and Date
2015-11-04
Related Report
Invited
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