Cross-talk between FGF receptor and integrin in breast cancer invasion and metastasis.
Project/Area Number |
26460471
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Experimental pathology
|
Research Institution | Osaka University |
Principal Investigator |
Mori Seiji 大阪大学, 医学系研究科, 招へい教授 (90467506)
|
Co-Investigator(Kenkyū-buntansha) |
松浦 成昭 大阪大学, 医学系研究科, 特任教授 (70190402)
河口 直正 大阪大学, 医学系研究科, 特任准教授(常勤) (70224748)
濱田 吉之輔 大阪大学, 医学系研究科, 特任准教授 (10362683)
|
Research Collaborator |
TAKADA Yoshikazu University of Carifornia Davis, 教授
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | インテグリン / FGF / FGFR / 腫瘍 / FGF受容体 / EMT |
Outline of Final Research Achievements |
We studied the role of αvβ3 induced by TGF-β on TGF-β-induced EMT. We elucidated that FGF1 bi-directionally regulated EMT induced by TGF-β1 in MCF10A mammary epithelial cells. TGF-β1 markedly amplified integrin αvβ3 and FGFR1. We studied if the enhancing effect of FGF1 on TGF-β1-induced EMT requires enhanced levels of both integrin αvβ3 expression and FGFR1. Knockdown of integrin β3 suppressed the enhancement by FGF1 of TGF-β1-induced EMT in MCF10A cells. Integrin-binding defective FGF1 mutant did not show bi-directional effect on TGF-β1-induced EMT in MCF10A cells. These findings suggest that enhanced integrin αvβ3 expression in addition to enhanced FGFR1 expression is critical for FGF1 to regulate TGF-β1-induced EMT in mammary epithelial cells.
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Report
(4 results)
Research Products
(19 results)
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[Journal Article] The integrin-binding defective FGF2 mutants potently suppress FGF2 signaling and angiogenesis.2017
Author(s)
Mori S, Hatori N, Kawaguchi N, Hamada Y, Shih TC, Wu CY, Lam KS, Matsuura N, Yamamoto H, Takada YK, Takada Y.
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Journal Title
Biosci Rep.
Volume: [Epub ahead of print]
Issue: 2
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Laminin α2-secreting fibroblasts enhance the therapeutic effect of skeletal myoblast sheets.2017
Author(s)
Uchinaka A, Tasaka K, Mizuno Y, Maeno Y, Ban T, Mori S, Hamada Y, Miyagawa S, Saito A, Sawa Y, Matsuura N, Nagata K, Yamamoto H, Kawaguchi N.
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Journal Title
European journal of Cardio-thoracic surgery
Volume: 51
Pages: 457-464
DOI
Related Report
Peer Reviewed
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