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Role of exosome on pancreatic desmoplasia

Research Project

Project/Area Number 26460476
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Experimental pathology
Research InstitutionNagoya City University

Principal Investigator

Fukamachi Katsumi  名古屋市立大学, 大学院医学研究科, 講師 (90381798)

Co-Investigator(Renkei-kenkyūsha) TSUDA Hiroyuki  名古屋市立大学, その他部局, 教授 (30094387)
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords膵癌 / 膵がん
Outline of Final Research Achievements

Pancreatic ductal adenocarcinoma is an extremely stroma-rich and highly aggressive solid tumor. The finding that exosomes contain proteins, nucleic acids suggests a role as mediators in cell-to-cell communication. The some of sorted miRNAs were packaged into exosomes, since the miRNA profiles in serum differ from those of the cancer tissues in rat pancreas cancer. It is suggested that exosomes and sorted miRNAs manipulate the cells in their microenvironment.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (4 results)

All 2018 2016 2014

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (3 results)

  • [Journal Article] Rat N-ERC/mesothelin as a marker for in vivo screening of drugs against pancreas cancer2014

    • Author(s)
      Fukamachi K, Iigo M, Hagiwara Y, Shibata K, Futakuchi M, Alexander DB, Hino O, Suzui M, Tsuda H.
    • Journal Title

      PLoS One

      Volume: 9 Issue: 10 Pages: 268-274

    • DOI

      10.1371/journal.pone.0111481

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 膵がん血清診断マーカーの探索2018

    • Author(s)
      深町 勝巳,二口 充,津田 洋幸,酒々井 眞澄
    • Organizer
      第34回日本毒性病理学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Establishment of a serum tumor marker for preclinical trials of rat pancreas cancer model2016

    • Author(s)
      Katsumi Fukamachi, Mitsuru Futakuchi, Hiroyuki Tsuda, Masumi Suzui
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-10-06
    • Related Report
      2016 Research-status Report
  • [Presentation] Identification of serum tumor marker of pancreas cancer by omics analysis2014

    • Author(s)
      Katsumi Fukamachi, Setsuko Yabushita, Mitsuru Futakuchi, Hiroyuki Tsuda, Masumi Suzui
    • Organizer
      発癌病理研究会
    • Place of Presentation
      いわき市
    • Year and Date
      2014-09-03
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2019-03-29  

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