Role of exosome on pancreatic desmoplasia
| Project/Area Number |
26460476
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Nagoya City University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
TSUDA Hiroyuki 名古屋市立大学, その他部局, 教授 (30094387)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 膵癌 / 膵がん |
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| Outline of Final Research Achievements |
Pancreatic ductal adenocarcinoma is an extremely stroma-rich and highly aggressive solid tumor. The finding that exosomes contain proteins, nucleic acids suggests a role as mediators in cell-to-cell communication. The some of sorted miRNAs were packaged into exosomes, since the miRNA profiles in serum differ from those of the cancer tissues in rat pancreas cancer. It is suggested that exosomes and sorted miRNAs manipulate the cells in their microenvironment.
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Report
(5 results)
Research Products
(4 results)
