Role of exosome on pancreatic desmoplasia

Research Project

Project/Area Number	26460476
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Experimental pathology
Research Institution	Nagoya City University
Principal Investigator	Fukamachi Katsumi 名古屋市立大学, 大学院医学研究科, 講師 (90381798)
Co-Investigator(Renkei-kenkyūsha)	TSUDA Hiroyuki 名古屋市立大学, その他部局, 教授 (30094387)
Project Period (FY)	2014-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000) Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords	膵癌 / 膵がん
Outline of Final Research Achievements	Pancreatic ductal adenocarcinoma is an extremely stroma-rich and highly aggressive solid tumor. The finding that exosomes contain proteins, nucleic acids suggests a role as mediators in cell-to-cell communication. The some of sorted miRNAs were packaged into exosomes, since the miRNA profiles in serum differ from those of the cancer tissues in rat pancreas cancer. It is suggested that exosomes and sorted miRNAs manipulate the cells in their microenvironment.

Report

(5 results)