Histone adaptation of cancer cell

• Project/Area Number: 26460482
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Experimental pathology
• Research Institution: National Cancer Center Japan
• Principal Investigator: Fujii Satoshi 国立研究開発法人国立がん研究センター, 先端医療開発センター, ユニット長 (30314743)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: Cancer / Histone / がん / ヒストン

Outline of Final Research Achievements

A tumor suppressor gene was regulated by cooperation of histone H3 variant incorporated by histone chaperone and histone modification working together with incorporation of histone H3 variant. On the other hand, incorporation of histone H3 variant did not lead to complete change of gene expression profiling distinguishing two different breast cancer subtypes.
Significant correlations between CAF (cancer associated with fibroblast)-TEM1-positivity or CAF-TEM1-intensity and RFS (recurrence-free survival), OS (overall survival), or COS (cancer-related overall survival) were observed (P < 0.001, Kaplan-Meier curves) regarding gastric cancer patients.

Research Products

• [Journal Article] TEM1 expression in cancer-associated fibroblasts is correlated with a poor prognosis in patients with gastric cancer. (2015)
  • Author(s): Fujii S, Fujihara A, Natori K, Abe A, Kuboki Y, Higuchi Y, Aizawa M, Kuwata T, Kinoshita T, Yasui W, Ochiai A.
  • Journal Title: Cancer Med. Volume: 4 Issue: 11 Pages: 1667-1678
  • DOI: 10.1002/cam4.515
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] 胃・十二指腸液逆流ラットモデルにおける発癌機構に関わるエピゲノム変化 (2016)
  • Author(s): 藤井誠志、関 聖矢、関 真秀、宮下 知治、武居 亮平、高田 智司、土原 一哉、太田 哲生、鈴木 穣
  • Organizer: 第75回日本癌学会総会
  • Place of Presentation: パシフィコ横浜 (神奈川県・横浜市)
  • Year and Date: 2016-10-06
• [Presentation] Histone modification and histone variant cooperatively regulate gene expression in cancer cells (2015)
  • Author(s): Fujii S, Suzuki Y, Ochiai A, Aoki F.
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 愛知県名古屋市
  • Year and Date: 2015-10-08
• [Presentation] 栄養飢餓応答としてのがんのオートファジー (2014)
  • Author(s): 藤井誠志
  • Organizer: 第55回日本組織細胞化学会総会・学術集会
  • Place of Presentation: 長野県松本市
  • Year and Date: 2014-09-27 – 2014-09-28
  • Invited
• [Presentation] がん関連線維芽細胞におけるTEM-1の発現は胃癌の予後不良に関係する (2014)
  • Author(s): 藤井誠志
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: 神奈川県横浜市
  • Year and Date: 2014-09-25 – 2014-09-27
• [Remarks]
  • URL: http://www.ncc.go.jp/jp/ncce/rcio/research/clip/sfujii.html