Elucidation of roles of MMP-1 in atherosclerosis and plaque rupture using transgenic rabbits
| Project/Area Number |
26460486
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | University of Yamanashi |
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Principal Investigator |
NIIMI Manabu 山梨大学, 総合研究部, 助教 (80644898)
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| Co-Investigator(Kenkyū-buntansha) |
西島 和俊 秋田大学, バイオサイエンス教育・研究サポートセンター, 准教授 (70435874)
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| Co-Investigator(Renkei-kenkyūsha) |
FAN Jianglin 山梨大学, 総合研究部, 教授 (60272192)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 動脈硬化 / 腹部大動脈瘤 / ウサギ / トランスジェニック / MMP-1 |
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| Outline of Final Research Achievements |
Increased expression of matrix metalloprotease-1 (MMP-1) has been implicated in atherosclerosis and aneurysms; however, it is not fully understood whether macrophage-derived MMP-1 affects atherosclerosis and aneurysm. To investigate this hypothesis, we generated transgenic (Tg) rabbits expressing human MMP-1 in macrophages under the control of human scavenger receptor promoter. After feeding a cholesterol rich diet, MMP-1 Tg rabbits had similar lesion size of aortic atherosclerosis compared with non-Tg rabbits; however, Tg rabbits showed a remarkable destruction of the medial elastic lamina in the aortic lesions. Using an elastase-induced aneurysm model, we found that Tg rabbits showed grater aortic dilation than non-Tg rabbits. These results indicate that macrophage-derived MMP-1 plays an important role in pathogenesis of vascular disease.
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Report
(4 results)
Research Products
(10 results)
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[Journal Article] Deficiency of Cholesteryl Ester Transfer Protein Protects Against Atherosclerosis in Rabbits.2017
Author(s)
Zhang, J. Niimi, M. Yang, D. Liang, J. Xu, J. Kimura, T. Mattew, A. V. Guo, Y. Fan, Y. Zhu, T. Song, J. Ackermann, R. Koike, Y. Schwendeman, A. Lai, L. Pennathur, S. Garcia-Barrio, M. Fan, J. Chen, Y. E.
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Journal Title
Arterioscler Thromb Vasc Biol
Volume: in press
Issue: 6
Pages: 1068-1075
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Angiotensin II Destabilizes Coronary Plaques in Watanabe Heritable Hyperlipidemic Rabbits.2016
Author(s)
Li S, Wang YN, Niimi M, Ning B, Chen Y, Kang D, Wang Z, Yu Q, Waqar AB, Liu E, Zhang J, Shiomi M, Chen YE, Fan J.
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Journal Title
Arterioscler Thromb Vasc Biol
Volume: 36
Issue: 5
Pages: 810-6
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Presentation] Angiotensin Ⅱ destabilizes coronary plaques in WHHL rabbits2016
Author(s)
Shen Li, Yan-ning Wang, Manabu Niimi, Bo Ning, Yajie Chen, Dedong Kang, Ziyun Wang, Qi Yu, Ahmed Bilal Waqar, Enqi Liu, Jifeng Zhang, Masashi Shiomi, Eugene Y. Chen, Jianglin Fan
Organizer
第48回 日本動脈硬化学会総会・学術集会
Place of Presentation
京王プラザホテル（東京都新宿区）
Year and Date
2016-07-14
Related Report
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[Presentation] CETP Deficiency in Rabbits Protects High Fat High Cholesterol Diet Induced Atherosclerosis2015
Author(s)
Jifeng Zhang, Jie Xu, Jingyan Liang, Dongshan Yang, Yanhong Guo, Tianqing Zhu, Jun Song, Manabu Niimi, Liangxue Lai, Jianglin Fan, Y. Eugene Chen
Organizer
Arteriosclerosis, Thrombosis and Vascular Biology/ Peripheral Vascular Disease Scientific Sessions
Place of Presentation
San Francisco (USA)
Year and Date
2015-05-07
Related Report
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