| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Outline of Final Research Achievements |
To prevent post-menopausal osteoporosis, persistent and reliable therapy is required. For this purpose, I am studying the regulation mechanisms of development of osteoclasts which resorb bone. I detected the osteoclastogenesis in both male and female mice is controlled by intra- and extra-medullary regulation. Cells for latter regulation are present in peritoneal cavities, and once lost, are not to be recovered. The flow cytometric analysis of bone marrow T cells did not show any significant difference with or without hypotonic treatment for removing peritoneal cells; however, the response to peritoneal cells is dependent on bone marrow T cells. The phenotype in these treated mice resembles the ovariectomized one carrying osteoporosis, suggesting the presence of common pathway in both conditions. The decision of the regulatory cells in the peritoneal cavity will result in the development of novel therapy for osteoporosis.
|
