Intracellular trafficking mechanism of erythrocyte invasion ligand molecule Plasmodium parasites

Research Project

Project/Area Number	26460507
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Parasitology (including sanitary zoology)
Research Institution	Tottori University
Principal Investigator	Otsuki Hitoshi 鳥取大学, 医学部, 准教授 (80403806)
Project Period (FY)	2014-04-01 – 2017-03-31
Project Status	Completed (Fiscal Year 2016)
Budget Amount *help	¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000) Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords	マラリア / 細胞内輸送 / 赤血球侵入
Outline of Final Research Achievements	Malaria parasites are single cell organism that invade into red blood cells of various animals. They secrete several proteins to attach on the surface of red blood cells to help their invasion. The molecule called EBL is an essential protein to attach on red cell surface irreversally. EBL is transported to the tip of the invasive form of the parasite. We identified the domain for this transport inside the molecule. And we also detected another important domain that influences the infectivity of the parasite.

Report

(4 results)