Intracellular trafficking mechanism of erythrocyte invasion ligand molecule Plasmodium parasites
| Project/Area Number |
26460507
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Parasitology (including sanitary zoology)
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| Research Institution | Tottori University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | マラリア / 細胞内輸送 / 赤血球侵入 |
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| Outline of Final Research Achievements |
Malaria parasites are single cell organism that invade into red blood cells of various animals. They secrete several proteins to attach on the surface of red blood cells to help their invasion. The molecule called EBL is an essential protein to attach on red cell surface irreversally. EBL is transported to the tip of the invasive form of the parasite. We identified the domain for this transport inside the molecule. And we also detected another important domain that influences the infectivity of the parasite.
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Report
(4 results)
Research Products
(3 results)
