| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Outline of Final Research Achievements |
It was not well understood what kind of environmental cues are perceived by Strongyloides infectious larvae (L3i), which leads to changes in gene expression and morphology. In the present study, we especially focused on studying mechanism of regulation of expression of GFAT1 gene, that was identified as one of the genes which showed remarkably up-regulated expression, once larvae are inside the animal host.
Taken the experimental results obtained in the present study together, we concluded that glucose concentration surrounding larvae are the most responsible for the elevation of GFAT1 expression. It was presumed that the elevation of GFAT1 expression is under the control of neurological pathway which involves muscarinic receptors.
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