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Visualization of immune responses against merozoites malaria infection

Research Project

Project/Area Number 26460512
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Parasitology (including sanitary zoology)
Research InstitutionUniversity of the Ryukyus

Principal Investigator

KISHIMOTO Hidehiro  琉球大学, 医学(系)研究科(研究院), 教授 (80251213)

Co-Investigator(Kenkyū-buntansha) 李 長春  琉球大学, 医学部, 非常勤講師 (20457691)
Co-Investigator(Renkei-kenkyūsha) KUBO Masato  東京理科大学, 生命医科学研究所, 教授 (40277281)
WATANABE Hisami  新潟大学, 国際感染症教育研究センター, 特任教授 (50143756)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsマラリア感染防御 / 免疫応答 / T細胞 / 赤血球型マラリア / CD8+T細胞 / 脾臓 / マラリア / 感染防御 / 免疫記憶 / ワクチン
Outline of Final Research Achievements

In this study, we investigated two questions; first, where dose immune-responses against to erythroid type malaria infection occur. Second, where establised memory T cells specific for the erythroid type malaria are mainteined. To visualize above questions, IFNγ-VENUS transgenic mice were infected with erythroid type malaria and analysed at various time points. Within 7 days, strong T cell response to erythroid type malaria is observed in the spleen whereas there is little immune responses found in other tissue i.e. lymphnodes, bonemarrows, liver. More than 60 days after infection, IFNγ-VENUS positive T cells are found in the spleen. These results indicated that the main tissue, in which immune-responses against to erythroid type malaria infection occur, revealed the spleen.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (16 results)

All 2017 2016 2015

All Journal Article (6 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 6 results,  Open Access: 5 results) Presentation (10 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Extra-luminal detection of assumed colonic tumor site by near-infrared laparoscopy.2016

    • Author(s)
      Zako T, Ito M, Hyodo H, Yoshimoto M, Watanabe M, Takemura H, Kishimoto H, Kaneko K, Soga K, Maeda M
    • Journal Title

      Surg Endosc

      Volume: 9 Pages: 4153-4159

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 希土類ナノ粒子OTN近赤外蛍光プローブによるマウスin vivoイメージングの応用2016

    • Author(s)
      岸本 英博, 福田啓介, 竹下寛之, 曽我公平
    • Journal Title

      バイオイメージング

      Volume: 25 Pages: 16-19

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Requirement of interleukin 7 signaling for anti-tumor immune response under lymphopenic conditions in a murine lung carcinoma model2016

    • Author(s)
      Suzuki T, Kishimoto H, Abe R.
    • Journal Title

      Cancer Immunol. Immunother.

      Volume: 65 Issue: 3 Pages: 341-354

    • DOI

      10.1007/s00262-016-1808-7

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Falciparum Malaria Incidentally Pretreated with Azithromycin2015

    • Author(s)
      Shibahara D, Kinjo T, Nishiyama N, Kami W, Nabeya D, Haranaga S, Higa F, Tateyama M, Shinzato T, Toma H, Kishimoto H, Fujita J.
    • Journal Title

      Internal Medicine

      Volume: 54 Issue: 19 Pages: 2513-2516

    • DOI

      10.2169/internalmedicine.54.5399

    • NAID

      130005101817

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Extra-luminal detection of assumed colonic tumor site by near-infrared laparoscopy.2015

    • Author(s)
      Zako T, Ito M, Hyodo H, Yoshimoto M, Watanabe M, Takemura H, Kishimoto H, Kaneko K, Soga K and Maeda, M.
    • Journal Title

      Surgical Endoscopy

      Volume: 29 Pages: 1-7

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] An asymmetric antibody repertoire is shaped between plasmablasts and plasma cells after secondary immunization with (4-hydroxy-3-nitrophenyl)acetyl chicken γ-globulin.2015

    • Author(s)
      Tashiro Y, Murakami A, Goizuka R, Shimizu T, Kishimoto H, Azuma T
    • Journal Title

      Int Immunol

      Volume: 12 Pages: 609-20

    • DOI

      10.1093/intimm/dxv040

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] VHH提示ファージライブラリーからの製品化を見据えた抗体作製法2017

    • Author(s)
      村上明一、塚原成俊、吉田麻衣子、與那嶺周平、岸本英博
    • Organizer
      第8回バイオメディカルインターフェイス・ワークショップ
    • Place of Presentation
      宮古島市中央公民館(沖縄県宮古島市)
    • Year and Date
      2017-03-09
    • Related Report
      2016 Annual Research Report
  • [Presentation] The infusion of adipose tissue-derived mesenchymal stem cells controls bone marrow aplasia accompanied with graft-versus-host disease in a mouse model Yukiko Nishi, Akikazu Murakami, Hidehiro Kishimot2016

    • Author(s)
      Yukiko Nishi, Akikazu Murakami, Hidehiro Kishimoto, Yuko Murayama, Sawako Nakachi, Satoko Morishima, Hiroaki Masuzaki
    • Organizer
      第45回日本免疫学会総会
    • Place of Presentation
      沖縄コンベンションセンター(沖縄県宜野湾市)
    • Year and Date
      2016-12-05
    • Related Report
      2016 Annual Research Report
  • [Presentation] 人工合成VHHファージディスプレイライブラリーから高い変性耐性を有するVHHクローンの単離と解析2016

    • Author(s)
      村上明一、吉田麻衣子、塚原成俊、岸本英博
    • Organizer
      第39回日本分子生物学会
    • Place of Presentation
      Pacifico横浜(神奈川県横浜市)
    • Year and Date
      2016-12-02
    • Related Report
      2016 Annual Research Report
  • [Presentation] Rapid isolation of useful antibodies from semi-synthetic Alpaca VHH phage display libraries2016

    • Author(s)
      Murakami A,Yoshida M, Azuma T, Nakayama H, Muraoka J, Kishimoto H
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      東北大学川内北キャンパス(宮城県仙台市)
    • Year and Date
      2016-09-26
    • Related Report
      2016 Annual Research Report
  • [Presentation] Isolation and characterization of target antigen specific VHHs from unique semi-synthetic alpaca VHH phage display libraries2016

    • Author(s)
      Murakami A,Yoshida M, Azuma T, Nakayama H, Muraoka J, Kishimoto H
    • Organizer
      16th International congress of Immunology
    • Place of Presentation
      Melbourne, Australia
    • Year and Date
      2016-08-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ユニークな戦略で多様性を創製したsemi-syntheticアルパカVHHファージディスプレイライブラリーからの標的抗原結合性クローンの単離と解析2015

    • Author(s)
      Murakami A, Yoshida M, Azuma T, Nakayama H, Muraoka J, Kishimoto H
    • Organizer
      第38回日本分子生物学会/第88回日本生化学会合同大会
    • Place of Presentation
      神戸ポートアイランド(兵庫県神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Research-status Report
  • [Presentation] The generation of multimeric and highly effective cytokines2015

    • Author(s)
      Tsukahara N, Nakayama M, Murakami A, Nishimura M, Azuma T, Kishimoto H
    • Organizer
      第44回 日本免疫学会総会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2015-11-18
    • Related Report
      2015 Research-status Report
  • [Presentation] An asymmetric antibody repertoire is shaped between plasmablast and plasma cells after secondary immunization with (4-hydroxy-3-nitrophenyl)acetyl chicken γ-globulin.2015

    • Author(s)
      Tashiro Y, Murakami A, Goitsuka R, Shimizu T, Kishimoto H, Azuma T
    • Organizer
      第44回 日本免疫学会総会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2015-11-18
    • Related Report
      2015 Research-status Report
  • [Presentation] 3-(1-ナフトイル)インドール誘導体に対する新規モノクローナル抗体の開発2015

    • Author(s)
      中山浩、村岡仁、村上明一、岸本英博
    • Organizer
      日本分析化学会第64年会
    • Place of Presentation
      九州大学伊都キャンパス(福岡県福岡市)
    • Year and Date
      2015-09-09
    • Related Report
      2015 Research-status Report
  • [Presentation] The generation of multimeric and highly active cytokine-Fc fusion protein2015

    • Author(s)
      Murakami A, Kishimoto H
    • Organizer
      The 15th Annual Meeting of the Federation of Clinical Immunology Societies
    • Place of Presentation
      San Diego, CA, USA
    • Year and Date
      2015-06-24
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research

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Published: 2014-04-04   Modified: 2018-03-22  

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