Membrane trafficking regulating LPS-induced autophagy
| Project/Area Number |
26460522
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Bacteriology (including mycology)
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| Research Institution | 公益財団法人結核予防会 結核研究所 (2015-2016)
Hamamatsu University School of Medicine (2014) |
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Principal Investigator |
Seto Shintaro 公益財団法人結核予防会 結核研究所, 生体防御部 免疫科, 研究員(移行) (50383203)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | オートファジー / LPS / Rab GTPase / レジオネラ菌 / エフェクタータンパク質 / 小胞輸送機構 / 結核菌 |
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| Outline of Final Research Achievements |
We screened Rab GTPase for regulators of LPS-induced autophagy. We have already identified that Rab39a binds to Beclin-1, PI3 kinase regulator and negatively regulates LPS-induce autophagy In this study, we found that Rab26 binds to Beclin-1 by immunoprecipitation analysis. Fluorescence microscopy analysis revealed that Rab26 localizes to lysosomes. Knock-down analysis showed that Rab26 negatively LPS-induced autophagy.
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Report
(4 results)
Research Products
(9 results)
