| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Xenobiotic transporter contributes to bacterial multidrug resistance by expelling antibacterial drugs. However, physiological roles of most of these transporters remain unknown. In this study, we focused on the ABC type transporter MacAB, and conducted physiological function analysis. There were findings that transporters were related with the bacterial attachment to the host cell surface, involved in resistance to oxidative stress, involved in maintenance of biofilm formation, and partly in bacterial survival in the intestine. In addition, inhibitor candidates of transporters were selected by the screening. In the situation where the physiological functions of many transporters are unknown, these results clarify their physiological functions and these are important information useful for the development of new drugs.
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