| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Bordetella bronchiseptica, a Gram-negative pathogenic bacterium causing respiratory infections in a broad range of mammals, is considered to have an evolutionary progenitor-like relationship to Bordetella pertussis and Bordetella parapertussis, which are causative agents of pertussis in humans. Previous comparative genomic analysis revealed that genetic differences may be associated with adaptation to the different hosts and different manifestations of disease. To get a clue to understand the underlying genetic differences associated with broad host range of B. bronchiseptica, we constructed several deletion mutant of genes specifically induced in rat trachea or with long-range deletion of B. bronchiseptica specific gene loci and examined whether these loci are involved in bacterial colonization of rat trachea. However, no apparent difference was found between wild-type B. bronchiseptica and mutants in its ability to establish respiratory infection in rats.
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