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Elucidation of gene appearance mechanism in genome

Research Project

Project/Area Number 26460529
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Bacteriology (including mycology)
Research InstitutionThe University of Tokushima

Principal Investigator

Maseda Hideaki  徳島大学, 大学院生物資源産業学研究部, 准教授 (10372343)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords緑膿菌 / 隠れ遺伝子 / 多剤耐性菌 / ゲノム進化 / ストレス耐性 / 遺伝子変異 / 解析ソフト / 遺伝子の自己編集 / バリエーション
Outline of Final Research Achievements

We have analyzed the mechanism by which genes are created in the region nonencoding genes in the genome. We desinged software that searches how many regions of such genomes are born or deleted in the genome. As a result of the search, it was revealed that such hidden genes existed in all analyzing organisms and ranged to tens of thousands in people. Sequences searched were selected randomly and it was confirmed whether gene-borning reactions occurred in those sequences. As a result, it was confirmed that reactions in which genes are born occur in all randomly selected sequences. Furthermore, artificially generating such a sequence and confirming whether or not gene-borning reactions occured, it was also confirmed that the same reaction occurred.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (6 results)

All 2016 2015

All Presentation (4 results) (of which Int'l Joint Research: 1 results,  Invited: 4 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 1 results)

  • [Presentation] 失って得られる緑膿菌の抗生物質耐性2016

    • Author(s)
      間世田 英明
    • Organizer
      第89回日本細菌学会総会
    • Place of Presentation
      大阪国際交流センター(大阪府・大阪市)
    • Year and Date
      2016-03-23
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 緑膿菌多剤排出ポンプはパーシステンスに貢献する2016

    • Author(s)
      間世田 英明
    • Organizer
      第89回日本細菌学会総会
    • Place of Presentation
      大阪国際交流センター(大阪府・大阪市)
    • Year and Date
      2016-03-23
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 緑膿菌の遺伝子制御系を読み解く2016

    • Author(s)
      間世田 英明
    • Organizer
      第50回緑膿菌感染症研究会
    • Place of Presentation
      ヒルトン東京お台場(東京都・港区)
    • Year and Date
      2016-02-05
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] DNAレベルでのスプライシングによる隠れ遺伝子発現機構2015

    • Author(s)
      間世田 英明
    • Organizer
      近畿バイオインダストリー振興会議
    • Place of Presentation
      「近畿バイオインダストリー振興会議(大阪府大阪市)」
    • Year and Date
      2015-02-12
    • Related Report
      2014 Research-status Report
    • Invited
  • [Patent(Industrial Property Rights)] ゲノム編集方法2016

    • Inventor(s)
      間世田英明、上手麻希
    • Industrial Property Rights Holder
      徳島大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2016-08-12
    • Related Report
      2016 Annual Research Report
  • [Patent(Industrial Property Rights)] 発現カセット2015

    • Inventor(s)
      間世田英明、上手麻希
    • Industrial Property Rights Holder
      徳島大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2015-01-30
    • Related Report
      2014 Research-status Report
    • Overseas

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Published: 2014-04-04   Modified: 2021-02-19  

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