Analyses of the functions of Bordetella BopC that induce actin-dependent necrotic cell death.
| Project/Area Number |
26460535
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Bacteriology (including mycology)
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| Research Institution | Kitasato University |
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Principal Investigator |
Kuwae Asaomi 北里大学, 感染制御科学府, 准教授 (60337996)
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| Co-Investigator(Renkei-kenkyūsha) |
ABE Akio 北里大学, 大学院感染制御科学府, 教授 (50184205)
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| Research Collaborator |
MOMOSE Fumitaka 北里大学, 大学院感染制御科学府, 講師
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 百日咳 / III型分泌機構 / エフェクター / 百日咳菌 / ボルデテラ属細菌 / III型分泌装置 / ネクローシス / 貪食阻害 / ボルデテラ |
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| Outline of Final Research Achievements |
Whooping cough is largely known as a vaccine preventable disease. However, there are many examples that children who were vaccinated have typical symptoms of whooping cough, meaning Bordetella pertussis, which is a causative agent of whooping cough, is obtaining resistance against the vaccine. It is also largely unknown the molecular mechanisms how B. pertussis cause the severe coughing. In the present study, we investigated the function of BopC, which is one of the virulence factors produced by Bordetella, during the bacterial infection. Our results suggest that BopC induce cell death against mammalian cells in the actin polymerization-dependent manner.
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Report
(4 results)
Research Products
(9 results)
