Mechanism of Fas-mediated inflammatory response against bacterial infection in vivo
| Project/Area Number |
26460539
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Bacteriology (including mycology)
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
TSUTSUI Hiroko 兵庫医科大学, 医学部, 主任教授 (40236914)
YONEHARA Shin 京都大学, 大学院・生命科学研究科, 教授 (00124503)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | Fasシグナル / 炎症性サイトカイン / 細菌感染 / Th17/Th1細胞 / 自然免疫 / Fas / IL-17 / IL-1b / Th17 / Listeria |
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| Outline of Final Research Achievements |
Fas signaling pathway is known to play a pivotal role in apoptosis induction. In addition, we have revealed that macrophages produced IL-1b by Fas-mediated inflammation in bacterial infection. However, the precise role of Fas-mediated cytokine production in actual pathogen infection was unclear. In this study, we found that Fas-mediated IL-1b contributes to the induction of novel helper T cells which produce IFN-g/IL-17 (called Th17/Th1 cells). This study provides a deeper understanding of the molecular mechanisms of Th17/Th1 induction during pathogenic microbe infection in vivo.
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Report
(4 results)
Research Products
(2 results)
