Counteractive functions of Tax and HBZ in pathogenesis of HTLV-1
| Project/Area Number |
26460554
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Virology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | HTLV-1 / ウイルス発がん |
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| Outline of Final Research Achievements |
It was found that HTLV-1 bZIP factor (HBZ) and Tax competitively bind to a tumor suppressor Rb, and dysregulate transcription of E2F-1 target genes in HTLV-1-infected cells. It was also found that Tax is transiently expressed in ATL cells and expression level of HBZ is negatively correlated with that of Tax. According to the results of single-cell qRT-PCR, it was suggested that Tax has anti-apoptotic function and HBZ accelerates cell proliferation.
It was shown that HBZ induces immune-related molecules such as T-cell immunoreceptor with Ig and ITIM domains (TIGIT), C-C motif chemokine receptor 4 (CCR4), IFN-gamma, and has important roles to fix the immunophenotypes of HTLV-1-infected cells.
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Report
(5 results)
Research Products
(69 results)
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[Journal Article] Enhancement of anti-STLV-1/HTLV-1 immune responses through multimodal effects of anti-CCR4 antibody.2016
Author(s)
Sugata K, Yasunaga JI, Miura M, Akari H, Utsunomiya A, Nosaka K, Watanabe Y, Suzushima H, Koh KR, Nakagawa M, Kohara M, Matsuoka M.
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Journal Title
Scientific report
Volume: 6
Issue: 1
Pages: 27150-27150
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Gpr176 is a Gz-linked orphan G-protein coupled receptor that sets the pace of circadian behavior.2016
Author(s)
Doi M, Murai I, Kunisue S, Setsu G, Uchio N, Tanaka R, Kobayashi S, Shimatani H, Hayashi H, Chao HW, Nakagawa Y, Takahashi Y, Hotta Y, Yasunaga JI, Matsuoka M, Hastings MH, Kiyonari H, and Okamura H.
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Journal Title
Nat Commun
Volume: 7
Issue: 1
Pages: 10583-10583
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Integrated molecular analysis of adult T cell leukemia/lymphoma.2015
Author(s)
Kataoka K, Nagata Y, Kitanaka A, Shiraishi Y, Shimamura T, Yasunaga J, Totoki Y, Chiba K, Sato-Otsubo A, Nagae G, et al.
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Journal Title
Nat Genet.
Volume: 47(11)
Issue: 11
Pages: 1304-15
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Experimental evaluation of the zoonotic infection potency of simian retrovirus type 4 using humanized mouse model2015
Author(s)
Kei Sato, Tomoko Kobayashi, Naoko Misawa, Rokusuke Yoshikawa, Junko S. Takeuchi, Tomoyuki Miura, Munehiro Okamoto, Jun-ichirou Yasunaga, Masao Matsuoka, Mamoru Ito, Takayuki Miyazawa & Yoshio Koyanagi
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Journal Title
Scientific Reports
Volume: 5
Issue: 1
Pages: 14040-14040
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] HTLV-1 Infection in Multiple Lineages of Hematopoietic Cells.2017
Author(s)
Furuta, R.,Yasunaga, JI., Miura, M., Sugata, K., Saito, A., Akari, H., Ueno, T., Takenouchi, N., Fujisawa, J., Kouh, K., Shimizu, M., Matsuda, F., Melamed, A., Bangham, CR., and Matsuoka, M
Organizer
18th Interbational Conference on Human Retrovirology HTLV and Related Viruses
Related Report
Int'l Joint Research
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[Presentation] HBZ downregulates miR-455, a tumor suppressor microRNA in ATL2017
Author(s)
Ma, G., Yasunaga, JI., Miura, M., Matsumoto, T., Matsuoka, M.
Organizer
第4回日本HTLV-1学会学術集会
Related Report
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[Presentation] Genome-wide association study of HTLV-1 associated myelopathy reveals association in the HLA locus in Japanese population.2014
Author(s)
Marina Penova, Jun-ichiro Yasunaga, Mineki Saito, Tomoo Sato, Satoshi Nozuma, Eiji Matsuura, Ryuji Kubota, Toshio Matsuzaki, Shuji Izumo, Hiroshi Takashima, Yoshihisa Yamano, Masao Matsuoka, Fumihiko Matsuda, Yasuharu Tabara.
Organizer
第1回日本HTLV-1学会学術集会
Place of Presentation
東京
Year and Date
2014-08-22 – 2014-08-24
Related Report
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