Counteractive functions of Tax and HBZ in pathogenesis of HTLV-1

• Project/Area Number: 26460554
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Virology
• Research Institution: Kyoto University
• Principal Investigator: Yasunaga Jun-ichirou 京都大学, ウイルス・再生医科学研究所, 講師 (40362404)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: HTLV-1 / ウイルス発がん

Outline of Final Research Achievements

It was found that HTLV-1 bZIP factor (HBZ) and Tax competitively bind to a tumor suppressor Rb, and dysregulate transcription of E2F-1 target genes in HTLV-1-infected cells. It was also found that Tax is transiently expressed in ATL cells and expression level of HBZ is negatively correlated with that of Tax. According to the results of single-cell qRT-PCR, it was suggested that Tax has anti-apoptotic function and HBZ accelerates cell proliferation.
It was shown that HBZ induces immune-related molecules such as T-cell immunoreceptor with Ig and ITIM domains (TIGIT), C-C motif chemokine receptor 4 (CCR4), IFN-gamma, and has important roles to fix the immunophenotypes of HTLV-1-infected cells.

Research Products

• [Int'l Joint Research] Imperial College London(英国)
• [Journal Article] Sporadic on/off switching of HTLV-1 Tax expression is crucial to maintain the whole population of virus-induced leukemic cells. (2018)
  • Author(s): Mahgoub M, Yasunaga JI, Iwami S, Nakaoka S, Koizumi Y, Shimura K, Matsuoka M.
  • Journal Title: Proc Natl Acad Sci U S A Volume: 115 Issue: 6 Pages: 529-538
  • DOI: 10.1073/pnas.1715724115
  • NAID: 120006697286
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo (2017)
  • Author(s): Furuta Rie、Yasunaga Jun-ichirou、Miura Michi、Sugata Kenji、Saito Akatsuki、Akari Hirofumi、Ueno Takaharu、Takenouchi Norihiro、Fujisawa Jun-ichi、Koh Ki-Ryang、Higuchi Yusuke、Mahgoub Mohamed、Shimizu Masakazu、Matsuda Fumihiko、Melamed Anat、Bangham Charles R.、Matsuoka Masao
  • Journal Title: PLOS Pathogens Volume: 13 Issue: 11 Pages: 1-22
  • DOI: 10.1371/journal.ppat.1006722
  • NAID: 120006697285
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Oncogenic spiral by infectious pathogens: Cooperation of multiple factors in cancer development (2017)
  • Author(s): Yasunaga Jun-Ichirou、Matsuoka Masao
  • Journal Title: Cancer Science Volume: 109 Issue: 1 Pages: 24-32
  • DOI: 10.1111/cas.13443
  • NAID: 120006460060
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic relevance of integrated genetic profiling in adult T-cell leukemia/lymphoma (2017)
  • Author(s): Kataoka Keisuke、Iwanaga Masako、Yasunaga Jun-ichirou、et al.
  • Journal Title: Blood Volume: 131 Issue: 2 Pages: 215-225
  • DOI: 10.1182/blood-2017-01-761874
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] HTLV-1 bZIP factor suppresses TDP1 expression through inhibition of NRF-1 in adult T-cell leukemia (2017)
  • Author(s): Takiuchi Yoko、Kobayashi Masayuki、Tada Kohei、Iwai Fumie、Sakurada Maki、Hirabayashi Shigeki、Nagata Kayoko、Shirakawa Kotaro、Shindo Keisuke、Yasunaga Jun-ichirou、Murakawa Yasuhiro、Rajapakse Vinodh、Pommier Yves、Matsuoka Masao、Takaori-Kondo Akifumi
  • Journal Title: Scientific Reports Volume: 7 Issue: 1 Pages: 12849-12849
  • DOI: 10.1038/s41598-017-12924-0
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] HTLV-1 bZIP Factor Enhances T-cell Proliferation by Impeding the Suppressive Signaling of Co inhibitory Receptors (2017)
  • Author(s): Haruka Kinosada, Jun-ichirou Yasunaga, Kazuya Shimura, Paola Miyazato, Chiho Onishi, Tomonori Iyoda, Kayo Inaba, Masao Matsuoka
  • Journal Title: PLoS Pathogens Volume: 13 Issue: 1 Pages: e1006120-e1006120
  • DOI: 10.1371/journal.ppat.1006120
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] HTLV-1 viral factor HBZ induces CCR4 to promote T cell migration and proliferation. (2016)
  • Author(s): Sugata K, Yasunaga JI, Kinosada H, Mitobe Y, Furuta R, Mahgoub M, Onishi C, Nakashima K, Ohshima K and Matsuoka M.
  • Journal Title: Cancer Research Volume: 76 Issue: 17 Pages: 5068-5079
  • DOI: 10.1158/0008-5472.can-16-0361
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Enhancement of anti-STLV-1/HTLV-1 immune responses through multimodal effects of anti-CCR4 antibody. (2016)
  • Author(s): Sugata K, Yasunaga JI, Miura M, Akari H, Utsunomiya A, Nosaka K, Watanabe Y, Suzushima H, Koh KR, Nakagawa M, Kohara M, Matsuoka M.
  • Journal Title: Scientific report Volume: 6 Issue: 1 Pages: 27150-27150
  • DOI: 10.1038/srep27150
  • NAID: 120005825906
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Multifaceted functions and roles of HBZ in HTLV-1 pathogenesis (2016)
  • Author(s): Ma G, Yasunaga JI, Matsuoka M
  • Journal Title: Retrovirology Volume: 13 Issue: 1 Pages: 16-16
  • DOI: 10.1186/s12977-016-0249-x
  • NAID: 120005947147
  • Peer Reviewed / Open Access
• [Journal Article] HTLV-1 bZIP factor protein targets the Rb/E2F-1 pathway to promote proliferation and apoptosis of primary CD4+ T cells. (2016)
  • Author(s): Kawatsuki A, Yasunaga JI, Mitobe Y, Green PL, and Matsuoka M.
  • Journal Title: Oncogene Volume: in press Issue: 34 Pages: 4509-4517
  • DOI: 10.1038/onc.2015.510
  • NAID: 120006477630
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] HTLV-1 bZIP Factor Impairs Anti-viral Immunity by Inducing Co-inhibitory Molecule, T cell Immunoglobulin and ITIM Domain (TIGIT). (2016)
  • Author(s): Yasuma K, Yasunaga JI, Takemoto K, Sugata K, Takenouchi N, Nakagawa M, Suzuki Y, and Matsuoka M.
  • Journal Title: PLoS Pathogens Volume: 12 Issue: 1 Pages: e1005372-e1005372
  • DOI: 10.1371/journal.ppat.1005372
  • NAID: 120005763385
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Gpr176 is a Gz-linked orphan G-protein coupled receptor that sets the pace of circadian behavior. (2016)
  • Author(s): Doi M, Murai I, Kunisue S, Setsu G, Uchio N, Tanaka R, Kobayashi S, Shimatani H, Hayashi H, Chao HW, Nakagawa Y, Takahashi Y, Hotta Y, Yasunaga JI, Matsuoka M, Hastings MH, Kiyonari H, and Okamura H.
  • Journal Title: Nat Commun Volume: 7 Issue: 1 Pages: 10583-10583
  • DOI: 10.1038/ncomms10583
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Integrated molecular analysis of adult T cell leukemia/lymphoma. (2015)
  • Author(s): Kataoka K, Nagata Y, Kitanaka A, Shiraishi Y, Shimamura T, Yasunaga J, Totoki Y, Chiba K, Sato-Otsubo A, Nagae G, et al.
  • Journal Title: Nat Genet. Volume: 47(11) Issue: 11 Pages: 1304-15
  • DOI: 10.1038/ng.3415
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] HTLV-1 bZIP factor (HBZ) RNA and protein impart distinct functions on T cell proliferation and survival. (2015)
  • Author(s): Mitobe Y, Yasunaga JI, Furuta R, and Matsuoka M.
  • Journal Title: Cancer Research Volume: 75 Issue: 19 Pages: 4143-4152
  • DOI: 10.1158/0008-5472.can-15-0942
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Experimental evaluation of the zoonotic infection potency of simian retrovirus type 4 using humanized mouse model (2015)
  • Author(s): Kei Sato, Tomoko Kobayashi, Naoko Misawa, Rokusuke Yoshikawa, Junko S. Takeuchi, Tomoyuki Miura, Munehiro Okamoto, Jun-ichirou Yasunaga, Masao Matsuoka, Mamoru Ito, Takayuki Miyazawa & Yoshio Koyanagi
  • Journal Title: Scientific Reports Volume: 5 Issue: 1 Pages: 14040-14040
  • DOI: 10.1038/srep14040
  • NAID: 120005753867
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Interferon-γ promotes inflammation and development of T-cell lymphoma in HTLV-1 bZIP factor transgenic mice. (2015)
  • Author(s): Mitagami Y, Yasunaga JI, Kinosada H, Ohshima K, and Matsuoka M.
  • Journal Title: PLoS Pathogens Volume: 11 Issue: 8 Pages: e1005120-e1005120
  • DOI: 10.1371/journal.ppat.1005120
  • NAID: 120005758434
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Protective effect of cytotoxic T lymphocytes targeting HTLV-1 bZIP factor. (2015)
  • Author(s): Sugata K, Yasunaga JI, Mitobe Y, Miura M, Miyazato P, Kohara M, and Matsuoka M.
  • Journal Title: Blood Volume: 126 Issue: 9 Pages: 1095-1105
  • DOI: 10.1182/blood-2015-04-641118
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] TCF1 and LEF1 act as T-cell intrinsic HTLV-1 antagonists by targeting Tax. (2015)
  • Author(s): Ma G, Yasunaga J-I, Akari H, and Matsuoka M
  • Journal Title: Proc. Natl. Acad. Sci. USA Volume: 112 Issue: 7 Pages: 2216-2221
  • DOI: 10.1073/pnas.1419198112
  • NAID: 120005537695
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] HTLV-1 bZIP factor suppresses apoptosis by attenuating the function of FoxO3a and altering its localization. (2014)
  • Author(s): Tanaka-Nakanishi A, Yasunaga J-I, Takai K and Matsuoka M
  • Journal Title: Cancer Res Volume: 74 Issue: 1 Pages: 188-200
  • DOI: 10.1158/0008-5472.can-13-0436
  • NAID: 120005587789
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Controlling leucine-zipper partner recognition in cells through modifications of a-g interactions. (2014)
  • Author(s): Azuma Y, Kükenshöner T, Ma G, Yasunaga JI, Imanishi M, Arndt KM, Matsuoka M, and Futaki S
  • Journal Title: Chem. Commun. Volume: 50 Issue: 48 Pages: 6364-6367
  • DOI: 10.1039/c4cc00555d
  • Peer Reviewed / Open Access
• [Presentation] HTLV-1 Infection in Multiple Lineages of Hematopoietic Cells. (2017)
  • Author(s): Furuta, R.,Yasunaga, JI., Miura, M., Sugata, K., Saito, A., Akari, H., Ueno, T., Takenouchi, N., Fujisawa, J., Kouh, K., Shimizu, M., Matsuda, F., Melamed, A., Bangham, CR., and Matsuoka, M
  • Organizer: 18th Interbational Conference on Human Retrovirology HTLV and Related Viruses
  • Int'l Joint Research
• [Presentation] Transient Tax Expression is Essential for ATL Survival: Insight Based on Single Cell Analysis (2017)
  • Author(s): Mahgoub, M., Yasunaga, JI., Shimura, K., Furuta, R., and Matsuoka, M
  • Organizer: 18th Interbational Conference on Human Retrovirology HTLV and Related Viruses
  • Int'l Joint Research
• [Presentation] HTLV-1 bZIP Factor Promotes T-cell Proliferation by Impairing the Suppressive Function of TIGIT and PD-1 (2017)
  • Author(s): Kinosada, H., Yasunaga, JI. Shimura, K., and Matsuoka, M
  • Organizer: 18th Interbational Conference on Human Retrovirology HTLV and Related Viruses
  • Int'l Joint Research
• [Presentation] HTLV-1 bZIP factorを抗原としたワクチンの開発と霊長類モデルによる効果の検証 (2017)
  • Author(s): 安永純一朗、菅田謙治、三浦未知、明里宏文、松岡雅雄
  • Organizer: 第27回抗ウイルス療法学会学術集会・総会
• [Presentation] HTLV-1による発がん機構 (2017)
  • Author(s): 安永純一朗
  • Organizer: 第20回日本レトロウイルス研究会 夏季セミナー
  • Invited
• [Presentation] HTLV-1がコードする2つのがん遺伝子taxとHTLV-1 bZIP factor の相反する機能と役割 (2017)
  • Author(s): 安永純一朗
  • Organizer: 第4回日本HTLV-1学会学術集会
  • Invited
• [Presentation] Characterization of p12, p30 and p13 Accessory Genes Conservation in Simian T-cell Leukemia Virus Type-1 (2017)
  • Author(s): Mahgoub, M. Yasunaga, JI., Tanabe, J., Matsuoka, M.
  • Organizer: 第4回日本HTLV-1学会学術集会
• [Presentation] IL-6の抑制はHBZによる炎症、発がんを加速する (2017)
  • Author(s): 樋口悠介、安永純一朗、三田上侑生、大島孝一、松岡雅雄
  • Organizer: 第4回日本HTLV-1学会学術集会
• [Presentation] 成人T細胞白血病細胞のクロマチン構造解析 (2017)
  • Author(s): 田中梓、安永純一朗、藤本明洋、松岡雅雄
  • Organizer: 第4回日本HTLV-1学会学術集会
• [Presentation] HTLV-1 bZIP factorによる c-fos遺伝子発現制御機構 (2017)
  • Author(s): 豊田康祐、安永純一朗、川月章弘、松岡雅雄
  • Organizer: 第4回日本HTLV-1学会学術集会
• [Presentation] HBZ downregulates miR-455, a tumor suppressor microRNA in ATL (2017)
  • Author(s): Ma, G., Yasunaga, JI., Miura, M., Matsumoto, T., Matsuoka, M.
  • Organizer: 第4回日本HTLV-1学会学術集会
• [Presentation] Transient expression of HTLV-1 Tax is critical event for persistence of adult T-cell leukemia cells (2017)
  • Author(s): Mahgoub, M., Yasunaga, JI., Iwami, S., and Matsuoka,M.
  • Organizer: 第76回日本癌学会学術総会
• [Presentation] HTLV-1 bZIP factor suppresses c-fos transcription to hijack cellular signaling pathways (2017)
  • Author(s): Toyoda, K., Yasunaga, JI., Kawatsuki, A., and Matsuoka, M.
  • Organizer: 第76回日本癌学会学術総会
• [Presentation] HTLV-1 bZIP factor downregulates miR-455, a tumor suppressor microRNA in ATL (2017)
  • Author(s): Yasunaga, JI., and Matsuoka, M.
  • Organizer: 第76回日本癌学会学術総会
• [Presentation] Loss of IL-6 accelerates inflammation and lymphomagenesis in HTLV-1 bZIP factor transgenic mice lymphomagenesis in HTLV-1 bZIP factor transgenic mice (2017)
  • Author(s): Higuchi, Y., Yasunaga, J., Mitagami, Y., Ohshima, K., and Matsuoka, M.
  • Organizer: 第79回日本血液学会学術集会
• [Presentation] Evolutional insight on accessory genes of simian T-cell leukemia virus type 1 (2017)
  • Author(s): Mahgoub, M., Yasunaga, JI., and Matsuoka, M.
  • Organizer: 第65回日本ウイルス学会学術集会
• [Presentation] HTLV-1 bZIP factor (HBZ) downregulates miR-455, a tumor suppressor microRNA in HTLV-1 infected cells (2017)
  • Author(s): Ma, G., Yasunaga, JI., and Matsuoka, M.
  • Organizer: 第65回日本ウイルス学会学術集会
• [Presentation] Functional Impairment of Co-Inhibitory Receptors Promotes T-Cell Proliferation in HTLV-1 Associated Adult T-Cell Leukemia Cells (2016)
  • Author(s): Kinosada, H., Yasunaga, JI., Shimura, K., Matsuoka, M.
  • Organizer: 58th ASH Annual Meeting and Exposition
  • Place of Presentation: San Diego
  • Year and Date: 2016-12-03
  • Int'l Joint Research
• [Presentation] HBZ promotes proliferation of CD4+T cells by impairing the suppressive signal from co-inhibitory molecules (2016)
  • Author(s): Kinosada, H,.Yasunaga, JI. and Matsuoka, M
  • Organizer: 第64回日本ウイルス学会学術集会
  • Place of Presentation: 札幌
  • Year and Date: 2016-10-23
• [Presentation] HBZ promotes proliferation of CD4+ T cells by interfering the suppressive function of co-inhibitory molecules (2016)
  • Author(s): Kinosada, H.,Yasunaga, JI., and Matsuoka, M.
  • Organizer: 第75回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2016-10-06
• [Presentation] Transient expression episodes of HTLV-1 Tax are essential for survival of adult T-cell leukemic cells (2016)
  • Author(s): Mahgoub, M., Yasunaga, JI., and Matsuoka, M.
  • Organizer: 第75回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2016-10-06
• [Presentation] ATL細胞におけるTaxの一過性発現とその意義 (2016)
  • Author(s): 安永純一朗、Mohamed Mohamed、松岡雅雄
  • Organizer: 第3回日本HTLV-1学会学術集会
  • Place of Presentation: 鹿児島
  • Year and Date: 2016-08-26
• [Presentation] HTLV-1 bZIP factorは共抑制分子の機能を阻害しT細胞の増殖を促進する (2016)
  • Author(s): 紀ノ定明香、安永純一朗、松岡雅雄
  • Organizer: 第3回日本HTLV-1学会学術集会
  • Place of Presentation: 鹿児島
  • Year and Date: 2016-08-26
• [Presentation] The role of interfereon-γ in development of T-cell Lymphoma and inflammation by HTLV-1 bZIP factor (2015)
  • Author(s): Yu Mitagami, Jun-ichirou Yasunaga, Haruka Kinosada, Koichi Ohsima, Masao Matsuoka
  • Organizer: 第63回日本ウイルス学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2015-11-22
• [Presentation] Pathogenic link between chronic inflammation and lymphomagenesis induced by HTLV-1 bZIP factor (2015)
  • Author(s): Jun-ichirou Yasunaga, Yu Mitagami, Haruka Kinosada, Koichi Ohshima, Masao Matsuoka
  • Organizer: 第77回日本血液学会学術集会
  • Place of Presentation: 石川
  • Year and Date: 2015-10-16
• [Presentation] Aberrant CpG island hypermethylation in adult T-cell leukemia/lymphoma (2015)
  • Author(s): Keisuke Kataoka, Teppei Shimamura, Akira Kitanaka, Genta Nagae, Yasunobu Nagata, Junichiro Yasunaga, et al.
  • Organizer: 第77回日本血液学会学術集会
  • Place of Presentation: 石川
  • Year and Date: 2015-10-16
• [Presentation] Immune response to STLV-1 bZIP factor is enhanced in STLV-1 infected Japanese monkeys after anti-CCR4 antibody treatment (2015)
  • Author(s): 安永純一朗、野坂生郷、小原道法、松岡雅雄
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 愛知
  • Year and Date: 2015-10-08
• [Presentation] HTLV-1 bZIP factor promotes proliferation of CD4+ T cells by interfering PD-1 inhibitory pathway (2015)
  • Author(s): 紀ノ定明香、安永純一朗、松岡雅雄
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 愛知
  • Year and Date: 2015-10-08
• [Presentation] Genome-wide analyses identify TIGIT as an HTLV-1 bZIP factor-induced gene (2015)
  • Author(s): 安間恵子、安永純一朗、松岡雅雄
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 愛知
  • Year and Date: 2015-10-08
• [Presentation] HTLV-1 bZIP factor RNA attenuates apoptosis through enhanced expression of survivin (2015)
  • Author(s): 水戸部悠一、安永純一朗、松岡雅雄
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 愛知
  • Year and Date: 2015-10-08
• [Presentation] HTLV-1 bZIP factor RNAは増殖を促進しアポトーシスを阻害する (2015)
  • Author(s): 水戸部悠一、安永純一朗、松岡雅雄
  • Organizer: 第2回日本HTLV-1学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2015-08-21
• [Presentation] HBZはCCR4発現を誘導する (2015)
  • Author(s): 菅田謙治、安永純一朗、古田梨愛、松岡雅雄
  • Organizer: 第2回日本HTLV-1学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2015-08-21
• [Presentation] HTLV-1 bZIP factor RNA attenuates apoptosis through enhanced expression of survivin (2015)
  • Author(s): 水戸部悠一、安永純一朗、松岡雅雄
  • Organizer: 第10回研究所ネットワーク国際シンポジウム
  • Place of Presentation: 北海道
  • Year and Date: 2015-07-23
• [Presentation] Anti-CCR4 antibody activates virus specific immune response in STLV-1 infected Japanese monkey. (2015)
  • Author(s): Kenji Sugata, Junichirou Yasunaga, Kisato Nosaka and Masao Matsuoka
  • Organizer: 17th International Conference on Human Retrovirology : HTLV & Related Viruses
  • Place of Presentation: Martinique, France
  • Year and Date: 2015-06-18
  • Int'l Joint Research
• [Presentation] Identification of TIGIT as an HBZ-Induced gene by genome-wide analyses: its association with evasion of host defense. (2015)
  • Author(s): Keiko Yasuma, Jun-ichirou Yasunaga, Keiko Takemoto, Kenji Sugata, Norihiro Takenouchi, Masanori Nakagawa, Yutaka Suzuki, Masao Matsuoka
  • Organizer: 17th International Conference on Human Retrovirology : HTLV & Related Viruses
  • Place of Presentation: Martinique, France
  • Year and Date: 2015-06-18
  • Int'l Joint Research
• [Presentation] HTLV-1 bZIP factor が惹起する炎症にお けるIFNγの役割 (2014)
  • Author(s): 三田上侑生、安永純一朗、大島孝一、松岡雅雄
  • Organizer: 第62回日本ウイルス学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2014-11-10 – 2014-11-12
• [Presentation] Anti-CCR4抗体はTregと感染細胞を同時に標的にする事で、STLV-1自然感染ニホンザルでのウイルス特異的免疫反応を活性化させる (2014)
  • Author(s): 菅田謙治、安永純一朗、三浦未知、明里宏文、小柳義夫、小原道法、松岡雅雄
  • Organizer: 第62回日本ウイルス学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2014-11-10 – 2014-11-12
• [Presentation] HTLV-1 bZIP factor (HBZ) はRbタンパクと相互作用し、E2F-1/Rb経路を改変する (2014)
  • Author(s): 川月章弘、安永純一朗、松岡雅雄
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] 転写因子TCF1、LEF1はHTLV-1 Taxを阻害し末梢Tリンパ球への感染指向性に関与する (2014)
  • Author(s): 安永純一朗、松岡雅雄
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] Genome-wide association study of HTLV-1 associated myelopathy reveals association in the HLA locus in Japanese population. (2014)
  • Author(s): Marina Penova, Jun-ichiro Yasunaga, Mineki Saito, Tomoo Sato, Satoshi Nozuma, Eiji Matsuura, Ryuji Kubota, Toshio Matsuzaki, Shuji Izumo, Hiroshi Takashima, Yoshihisa Yamano, Masao Matsuoka, Fumihiko Matsuda, Yasuharu Tabara.
  • Organizer: 第1回日本HTLV-1学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2014-08-22 – 2014-08-24
• [Presentation] 宿主F-boxタンパク質FBXL11はTaxとHBZのユビキチン化を誘導し機能を活性化する (2014)
  • Author(s): 安永純一朗、園直希、馬広勇、萩谷啓太、松岡雅雄
  • Organizer: 第1回日本HTLV-1学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2014-08-22 – 2014-08-24
• [Presentation] HTLV-1 bZIP factorが惹起する炎症にはIFNγが重要な役割を果たす (2014)
  • Author(s): 三田上侑生、安永純一朗、大島孝一、松岡雅雄
  • Organizer: 第1回日本HTLV-1学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2014-08-22 – 2014-08-24
• [Presentation] TCF1/LEF1 are T-cell natural HTLV-1 Tax antagonists that restrict viral expansion in thymus. (2014)
  • Author(s): Guangyong Ma, Jun-ichiro Yasunaga, Masao Matsuoka.
  • Organizer: 第1回日本HTLV-1学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2014-08-22 – 2014-08-24
• [Book] Viruses and human cancer (2014)
  • Author(s): Yasunaga J and Matsuoka M.
  • Total Pages: 386
  • Publisher: Springer
• [Book] Cancer-Causing Viruses and Their Inhibitors (2014)
  • Author(s): Yasunaga J
  • Total Pages: 511
  • Publisher: CRC Press
• [Remarks] ヒトT細胞白血病ウイルス1型（HTLV-1）の新しい感染維持機構を解明
  • URL: http://www.infront.kyoto-u.ac.jp/achievements/post-3010/
• [Remarks] ヒトT細胞白血病ウイルス1型（HTLV－1）の新しい感染維持機構を解明
  • URL: http://www.kyoto-u.ac.jp/ja/research/research_results/2017/180123_1.html
• [Remarks] The fewer the deadlier
  • URL: https://www.kyoto-u.ac.jp/en/research/research_results/2017/180123_1.html