| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
We analyzed the viral gene regulation of gammaherpesvirus. The open reading frame (ORF) 35 protein was considered to be essential for the viral growth. However, we revealed that the protein was not essential, but plays an important role for the efficiency of the viral replication. In addition, ORF35 protein was necessary for reactivation from latent infection.
We also analyzed the function of ORF31 protein. And the protein was revealed to regulate viral gene expression and we identified functional domain of ORF31. Host proteins which bind to ORF31 and regulate viral replication was searched, and we found candidates. We are currently studying about these proteins.
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