| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
The epidemiological study on type I diabetes mellitus and acute pancreatitis strongly suggests the pathogenicity of SAFV to pancreas. However, we could not establish the relationship between the diseases and SAFV infection since the number of cases was not enough. The study of the receptor for SAFV infection is also ongoing. On the other hand, unexpected findings were obtained in this study. We found that the PEST sequence in SAFV VP1 is a responsible element for its instability. The degradation of SAFV VP1 was suppressed with the co-expression of other capsid proteins, suggesting that the PEST sequence is masked and VP1 is stabilized during capsid formation. In addition, unknown viral protein was found, presumably translated from a non-AUG codon in an IRES dependent manner.
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