Will Saffold virus infection be a trigger of autoimmune disease (especially type 1 diabetes)?
Project/Area Number |
26460561
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Virology
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Research Institution | Kanazawa Medical University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
大桑 孝子 金沢医科大学, 医学部, 助教 (20460347)
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Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | Saffoldウイルス / 糖尿病 / 膵炎 / ウイルス蛋白 / 感染受容体 / 膵臓 / 急性膵炎 / Saffold ウイルス / 持続感染 |
Outline of Final Research Achievements |
The epidemiological study on type I diabetes mellitus and acute pancreatitis strongly suggests the pathogenicity of SAFV to pancreas. However, we could not establish the relationship between the diseases and SAFV infection since the number of cases was not enough. The study of the receptor for SAFV infection is also ongoing. On the other hand, unexpected findings were obtained in this study. We found that the PEST sequence in SAFV VP1 is a responsible element for its instability. The degradation of SAFV VP1 was suppressed with the co-expression of other capsid proteins, suggesting that the PEST sequence is masked and VP1 is stabilized during capsid formation. In addition, unknown viral protein was found, presumably translated from a non-AUG codon in an IRES dependent manner.
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Report
(4 results)
Research Products
(12 results)
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[Journal Article] Saffold Cardiovirus Infection in a 2-Year-Old Boy with Acute Pancreatitis2017
Author(s)
Ito H, Miyagaki S, Sakaue S, Matsui F, Katsumi Y, Otabe O, Torii J, Itagaki T, Himeda T, Okuwa T, Ohara Y
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Journal Title
Japanese Journal of Infectious Diseases
Volume: 70
Issue: 1
Pages: 105-107
DOI
NAID
ISSN
1344-6304, 1884-2836
Related Report
Peer Reviewed / Acknowledgement Compliant
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