Analysis of regulation mechanisms of hepatitis B virus life cycle by kinases and post-translational modifications

• Project/Area Number: 26460565
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Virology
• Research Institution: National Institute of Infectious Diseases
• Principal Investigator: Watashi Koichi 国立感染症研究所, ウイルス第二部, 主任研究官 (40378948)
• Research Collaborator: Tsukuda Senko 国立感染症研究所, ウイルス第二部, 協力研究員 ; Iwamoto Masashi 国立感染症研究所, ウイルス第二部, 研究生 ; Ohashi Hirofumi 国立感染症研究所, ウイルス第二部, 研究生
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 肝炎ウイルス / 翻訳後修飾 / HBV / B型肝炎ウイルス / ウイルス / 肝炎 / 複製 / 化合物 / 微小管

Outline of Final Research Achievements

Molecular mechanisms underlying hepatitis B virus (HBV) life cycle has not been fully clarified. In this study, we identified host factors regulating HBV life cycle and analyzed its regulation mechanism by using cell models efficiently supporting HBV infection and replication. Through the identification of nocodazole that inhibited HBV replication, we revealed that cellular microtubules were important for the multimerization of core protein and post-translational modification of tubulin regulated HBV replication. We also identified cellular kinases that regulated HBV entry process. These findings provide information important for understanding the molecular mechanisms of virus-host interaction.

Research Products

• [Int'l Joint Research] Los Alamos National Laboratory/Indiana University School of Medicine(米国)
• [Int'l Joint Research] University of the Witwatersrand(南アフリカ)
• [Int'l Joint Research] INTS(フランス)
• [Int'l Joint Research] Los Alamos National Laboratory/SCYNEXIS, Inc./University of Chicago(米国)
• [Int'l Joint Research] INTS(フランス)
• [Int'l Joint Research] Erasmus MC-University Medical Center(オランダ)
• [Int'l Joint Research] National Taiwan University(台湾)
• [Int'l Joint Research] INTS(フランス)
• [Int'l Joint Research] All India Institute of Medical Sciences/Transl Health Sci Technol Inst/Intl Center Genet Eng Biotechnol(インド)
• [Int'l Joint Research] Erasmus MC-University Medical Center(オランダ)
• [Int'l Joint Research]
• [Journal Article] Chemical array system, a platform to identify novel hepatitis B virus entry inhibitors targeting sodium taurocholate cotransporting polypeptide (2018)
  • Author(s): Kaneko M, Futamura Y, Tsukuda S, Kondoh Y, Sekine T, Hirano H, Fukano K, Ohashi H, Saso W, Morishita R, Matsunaga S, Kawai F, Ryo A, Park S-Y, Suzuki R, Aizaki H, Ohtani N, Sureau C, Wakita T, Osada H, Watashi K
  • Journal Title: Scientific Reports Volume: 8 Issue: 1 Pages: 2769-2769
  • DOI: 10.1038/s41598-018-20987-w
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Novel stable HBV producing cell line systems for expression and screening antiviral inhibitor of hepatitis B virus in human hepatoma cell line (2018)
  • Author(s): Ogura N, Ogawa K, Watashi K, Ito T, Wakita T
  • Journal Title: Biochem Biophys Res Commun Volume: 498 Issue: 1 Pages: 64-71
  • DOI: 10.1016/j.bbrc.2018.02.175
  • Peer Reviewed
• [Journal Article] De Novo Macrocyclic Peptide Inhibitors of Hepatitis B Virus Cellular Entry. (2018)
  • Author(s): Passioura T, Watashi K, Fukano K, Shimura S, Saso W, Morishita R, Ogasawara Y, Tanaka Y, Mizokami M, Sureau C, Suga H, Wakita T.
  • Journal Title: Cell Chem Biol. Volume: 25 Issue: 7 Pages: 906-915
  • DOI: 10.1016/j.chembiol.2018.04.011
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 冠Award受賞者の声 平成29年度第16回MSD Award (2018)
  • Author(s): 渡士幸一
  • Journal Title: 肝臓 Volume: 59 Pages: 71-71
• [Journal Article] Reply to Padmanabhan and Dixit: Hepatitis C virus entry inhibitors for optimally boosting direct-acting antiviral-based treatments. (2017)
  • Author(s): Ohashi HK, Koizumi Y, Fukano K, Wakita T, Perelson AS, Iwami S, Watashi K
  • Journal Title: Proc Acad Natl Acad USA Volume: 114 Issue: 23
  • DOI: 10.1073/pnas.1705234114
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Hepatitis B virus prevents excessive viral production via reduction of cell death-inducing DFF45-like effectors (2017)
  • Author(s): Yasumoto Jun、Kasai Hirotake、Yoshimura Kentaro、Otoguro Teruhime、Watashi Koichi、Wakita Takaji、Yamashita Atsuya、Tanaka Tomohisa、Takeda Sen、Moriishi Kohji
  • Journal Title: Journal of General Virology Volume: 98 Issue: 7 Pages: 1762-1773
  • DOI: 10.1099/jgv.0.000813
  • Peer Reviewed
• [Journal Article] ssAAVs containing cassettes encoding SaCas9 and guides targeting hepatitis B virus inactivate replication of the virus in cultured cells (2017)
  • Author(s): Scott T, Moyo B, Nicholson S, Maepa MB, Watashi K, Ely A, Weinberg MS, Arbuthnot P
  • Journal Title: Sci Rep Volume: 7 Issue: 1 Pages: 7401-7401
  • DOI: 10.1038/s41598-017-07642-6
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Functional association of cellular microtubules with viral capsid assembly supports efficient hepatitis B virus replication (2017)
  • Author(s): Iwamoto M、Cai D、Sugiyama M、Suzuki R、Aizaki H、Ryo A、Ohtani N、Tanaka Y、Mizokami M、Wakita T、Guo H、Watashi K
  • Journal Title: Sci Rep Volume: 7 Issue: 1 Pages: 10620-10620
  • DOI: 10.1038/s41598-017-11015-4
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Involvement of PUF60 in Transcriptional and Post-transcriptional Regulation of Hepatitis B Virus Pregenomic RNA Expression (2017)
  • Author(s): Sun Suofeng、Nakashima Kenji、Ito Masahiko、Li Yuan、Chida Takeshi、Takahashi Hirotaka、Watashi Koichi、Sawasaki Tatsuya、Wakita Takaji、Suzuki Tetsuro
  • Journal Title: Scientific Reports Volume: 7 Issue: 1 Pages: 12874-12874
  • DOI: 10.1038/s41598-017-12497-y
  • Peer Reviewed / Open Access
• [Journal Article] 抗B型肝炎ウイルス薬の現状と新規薬剤開発のアプローチ (2017)
  • Author(s): 九十田千子、渡士幸一
  • Journal Title: 化学療法の領域 Volume: 33 Pages: 73-78
• [Journal Article] 抗ウイルス薬の個性を知る ～ウイルス学と数学の融合研究によるC型肝炎治療薬併用の薬効評価と最適化～ (2017)
  • Author(s): 大橋啓史、渡士幸一
  • Journal Title: ウイルス Volume: 67 Pages: 133-142
  • NAID: 40021454099
• [Journal Article] 目覚ましいC型肝炎治療の進歩 (2017)
  • Author(s): 渡士幸一
  • Journal Title: 感染 炎症 免疫 Volume: 47 Pages: 71-72
• [Journal Article] Reply to Padmanabhan and Dixit: Hepatitis C virus entry inhibitors for optimally boosting direct-acting antiviral-based treatments (2017)
  • Author(s): Ohashi H, Koizumi Y, Fukano K, Wakita T, Perelson AS, Iwami S, Watashi K*
  • Journal Title: Proc Natl Acad Sci USA Volume: NA
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Hepatitis B virus prevents excessive viral production via reduction of cell-death inducing DFF45-like effectors (2017)
  • Author(s): Yasumoto J, Kasai H, Yoshimura K, Otoguro T, Watashi K, Wakita T, Yamashita A, Tanaka T, Takeda S, Moriishi K
  • Journal Title: J Gen Virol Volume: NA
  • Peer Reviewed
• [Journal Article] Establishment of a human hepatocellular cell line capable of maintaining long-term replication of hepatitis B virus (2017)
  • Author(s): Yao WL, Ikeda S, Tsukamoto Y, Shindo K, Otakaki Y, Qin M, Iwasawa Y, Takeuchi F, Kaname Y, Chou YC, Chang C, Watashi K, Wakita T, Noda T, Kato H, Fujita T
  • Journal Title: Int Immunol Volume: NA Issue: 3 Pages: 109-120
  • DOI: 10.1093/intimm/dxx012
  • Peer Reviewed
• [Journal Article] Stereo-controlled synthesis of functionalized tetrahydropyridines based on the cyanomethylation of 1,6-dihydropyridines and generation of anti-hepatitis C virus agents (2017)
  • Author(s): Watanabe R, Mizoguchi H, Oikawa H, Ohashi H, Watashi K, Oguri H
  • Journal Title: Bioorg Med Chem Volume: NA Issue: 11 Pages: 2851-2855
  • DOI: 10.1016/j.bmc.2017.03.011
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Human induced-pluripotent stem cell-derived hepatocyte-like cells as an in vitro model of human hepatitis B virus infection. (2017)
  • Author(s): Sakurai F, Mitani S, Yamamoto T, Takayama K, Tachibana M, Watashi K, Wakita T, Iijima S, Tanaka Y, Mizuguchi H
  • Journal Title: Scientific Reports Volume: 7 Issue: 1 Pages: 45698-45698
  • DOI: 10.1038/srep45698
  • Peer Reviewed / Open Access
• [Journal Article] Gut microbiota promotes obesity-associated liver cancer through PGE2-mediated suppression of antitumor immunity. (2017)
  • Author(s): Loo TM, Kamachi F, Watanabe Y, Yoshimoto S, Kanda H, Arai Y, Nakajima-Takagi Y, Iwama A, Koga T, Sugimoto Y, Ozawa T, Nakamura M, Kumagai M, Watashi K, Taketo M, Aoki T, Narumiya S, Oshima M, Arita M, Hara E, Ohtani N.
  • Journal Title: Cancer Discov Volume: in press Issue: 5 Pages: 522-538
  • DOI: 10.1158/2159-8290.cd-16-0932
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Quantifying antiviral activity optimizes drug combinations against hepatitis C virus infection (2017)
  • Author(s): Koizumi Y, Ohashi H, Nakajima S, Tanaka Y, Wakita T, Perelson AS, Iwami S, Watashi K
  • Journal Title: Proc Natl Acad Sci U S A Volume: 114(8) Issue: 8 Pages: 1922-1927
  • DOI: 10.1073/pnas.1610197114
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Cyclosporin derivatives inhibit hepatitis B virus entry without interfering with NTCP transporter activity. (2017)
  • Author(s): Shimura S, Watashi K, Fukano K, Peel M, Sluder A, Kawai F, Iwamoto M, Tsukuda S, Takeuchi S J, Miyake T, Sugiyama M, Ogasawara Y, Park SY, Tanaka Y, Kusuhara H, Mizokami M, Sureau C, Wakita T
  • Journal Title: J Hepatol Volume: 66 Issue: 4 Pages: 685-692
  • DOI: 10.1016/j.jhep.2016.11.009
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A new class of hepatitis B and D virus entry inhibitors, proanthocyanidin and its analogs, that directly act on the viral large surface proteins. (2017)
  • Author(s): Tsukuda S, Watashi K, Hojima T, Isogawa M, Iwamoto M, Omagari K, Suzuki R, Aizaki H, Kojima S, Sugiyama M, Saito A, Tanaka Y, Mizokami M, Sureau C, Wakita T
  • Journal Title: Hepatology Volume: 65 Issue: 4 Pages: 1104-1116
  • DOI: 10.1002/hep.28952
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Host factor PRPF31 is involved in cccDNA production in HBV-replicating cells (2017)
  • Author(s): Kinoshita W, Ogura N, Watashi K, Wakita T
  • Journal Title: Biochem Biophys Res Commun Volume: 482 Issue: 4 Pages: 638-644
  • DOI: 10.1016/j.bbrc.2016.11.085
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Hepatitis B virus X protein impairs α-interferon signaling via up-regulation of suppressor of cytokine signaling 3 and protein phosphatase 2A. (2017)
  • Author(s): Tsunematsu S, Suda G, Yamasaki K, Kimura M, Izumi T, Umemura M, Ito J, Sato F, Nakai M, Sho T, Morikawa K, Ogawa K, Tanaka Y, Watashi K, Wakita T, Sakamoto N
  • Journal Title: J Med Virol Volume: 89 Issue: 2 Pages: 267-275
  • DOI: 10.1002/jmv.24643
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] 抗Ｂ型肝炎ウイルス薬の現状と新規薬剤開発のアプローチ (2017)
  • Author(s): 九十田千子, 渡士幸一
  • Journal Title: 化学療法の領域 Volume: 33 Pages: 73-78
• [Journal Article] Isolation and characterization of hepatitis C virus resistant to a novel phenanthridinone derivative (2016)
  • Author(s): Ito W, Toyama M, Okamoto M, Ikeda M, Watashi K, Wakita T, Hashimoto Y, Baba M
  • Journal Title: Antivir Chem Chemother Volume: 24 Issue: 5-6 Pages: 148-154
  • DOI: 10.1177/2040206616663956
  • Peer Reviewed
• [Journal Article] Closing the door on hepatitis B and D virus entry: what are our therapeutic options? (2016)
  • Author(s): Iwamoto M and Watashi K
  • Journal Title: Future Virology Volume: 11 Issue: 11 Pages: 715-718
  • DOI: 10.2217/fvl-2016-0097
  • Peer Reviewed
• [Journal Article] Fungus-Derived Neoechinulin B as a Novel Antagonist of Liver X Receptor, Identified by Chemical Genetics Using a Hepatitis C Virus Cell Culture System (2016)
  • Author(s): Nakajima S, Watashi K, Ohashi H, Kamisuki S, Izaguirre-Carbonell J, Kwon AT, Suzuki H, Kataoka M, Tsukuda S, Okada M, Moi ML, Takeuchi T, Arita M, Suzuki R, Aizaki H, Kato T, Suzuki T, Hasegawa H, Takasaki T, Sugawara F, Wakita T
  • Journal Title: J Virol Volume: 90(20) Issue: 20 Pages: 9058-74
  • DOI: 10.1128/jvi.00856-16
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Interferon-stimulated gene of 20KDa protein (ISG20) degrades RNA of hepatitis B virus to impede the replication of HBV in vitro and in vivo (2016)
  • Author(s): Leong CR, Funami K, Oshiumi H, Mengao D, Takaki H, Matsumoto M, Ali HH, Watashi K, Chayama K, Seya T
  • Journal Title: Oncotarget Volume: 7 Pages: 68179-681193
  • Peer Reviewed
• [Journal Article] Human induced pluripotent stem cell-derived hepatic cell line as a new model for host interaction with hepatitis B virus. (2016)
  • Author(s): Kaneko S, Kakinuma S, Asahina Y, Kamiya A, Miyoshi M, Tsunoda T, Nitta S, Asano Y, Nagata H, Otani S, Kitahata F, Murakawa M, Itsui Y, Nakagawa M, Azuma S, Nakauchi H, Iwamoto M, Watashi K, Wakita T, Sugiyama M, Mizokami M, Shimotohno K, Watanabe M.
  • Journal Title: Sci Rep Volume: ６ Issue: 1 Pages: 29358-29358
  • DOI: 10.1038/srep29358
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] HBV slow maturation process leading to infection (2016)
  • Author(s): Watashi K*
  • Journal Title: Trends Microbiol Volume: 24 Issue: 8 Pages: 597-599
  • DOI: 10.1016/j.tim.2016.06.007
  • Peer Reviewed
• [Journal Article] Bivalent vaccine platform based on Japanese encephalitis virus (JEV) elicit neutralizing antibodies against JEV and hepatitis C virus (2016)
  • Author(s): Saga R, Fujimoto A, Watanabe N, Matsuda M, Hasegawa M, Watashi K, Aizaki H, Nakamura N, Tajima S, Takasaki T, Konishi E, Kato T, Kohara M, Takeyama H, Wakita T, Suzuki R
  • Journal Title: Sci Rep Volume: 6 Issue: 1 Pages: 28688-28688
  • DOI: 10.1038/srep28688
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] RNA exosome complex regulates stability of Hepatitis B Virus's X-mRNA transcript in a Non-Stop mediated (NSD) RNA quality control mechanism. (2016)
  • Author(s): Hussein H. Aly, Junya Suzuki, Koichi Watashi, Kazuaki Chayama, Shin-ichi Hoshino, Makoto Hijikata, Takanobu Kato, and Takaji Wakita
  • Journal Title: J Biol Chem Volume: 291 Issue: 31 Pages: 15958-15974
  • DOI: 10.1074/jbc.m116.724641
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Fatty acid biosynthesis is involved in the production of hepatitis B virus particles (2016)
  • Author(s): Okamura H, Nio Y, Akahori Y, Kim S, Watashi K, Wakita T, Hijikata M
  • Journal Title: Biochem Biophys Res Commun Volume: 475 Issue: 1 Pages: 87-92
  • DOI: 10.1016/j.bbrc.2016.05.043
  • Peer Reviewed
• [Journal Article] Single-domain Intrabodies against HCV Core Inhibit Viral Propagation and Core-induced NF-κB Activation (2016)
  • Author(s): Suzuki R, Saito K, Matsuda M, Sato M, Kanegae Y, Shi G, Watashi K, Aizaki H, Chiba J, Saito I, Wakita T, Suzuki T
  • Journal Title: J Gen Virol Volume: 印刷中 Issue: 4 Pages: 887-892
  • DOI: 10.1099/jgv.0.000423
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Ｂ型肝炎ウイルス研究のトピックス (2016)
  • Author(s): 渡士幸一, 相崎英樹
  • Journal Title: 小児科 Volume: 57 Pages: 1107-1111
• [Journal Article] Prolactin Regulatory Element Binding Protein Is Involved in Hepatitis C Virus Replication by Interaction with NS4B (2016)
  • Author(s): Kong L, Fujimoto A, Nakamura M, Aoyagi H, Matsuda M, Watashi K, Suzuki R, Arita M, Yamagoe S, Dohmae N, Suzuki T, Sakamaki Y, Ichinose S, Suzuki T, Wakita T, Aizaki H
  • Journal Title: J Virol Volume: 90 Issue: 6 Pages: 3093-3111
  • DOI: 10.1128/jvi.01540-15
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Anti-hepatitis C Virus Natural Product from a Fungus, Penicillium herquei (2016)
  • Author(s): Nishikori S, Takemoto K, Kamisuki S, Nakajima S, Kuramochi K, Tsukuda S, Iwamoto M, Katayama Y, Suzuki T, Kobayashi S, Watashi K, Sugawara F
  • Journal Title: J Nat Prod Volume: 79 Issue: 2 Pages: 442-446
  • DOI: 10.1021/acs.jnatprod.5b00555
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Hepatocyte Factor JMJD5 Regulates Hepatitis B Virus Replication through Interaction with HBx (2016)
  • Author(s): Kouwaki T, Okamoto T, Ito A, Sugiyama Y, Yamashita K, Suzuki T, Kusakabe S, Hirano J, Fukuhara T, Yamashita A, Saito K, Okuzaki D, Watashi K, Sugiyama M, Yoshio S, Standley DM, Kanto T, Mizokami M, Moriishi K, Matsuura Y
  • Journal Title: J Virol Volume: 90 Issue: 7 Pages: 3530-3542
  • DOI: 10.1128/jvi.02776-15
  • Peer Reviewed
• [Journal Article] Inhibition of preS1-hepatocyte interaction by an array of recombinant human antibodies from naturally recovered individuals (2016)
  • Author(s): Sankhyan A, Sharma C, Dutta D, Sharma T, Chosdol K, Wakita T, Watashi K, Awasthi A, Acharya SK, Khanna N, Tiwari A, Sinha S
  • Journal Title: Sci Rep Volume: 6 Issue: 1 Pages: 21240-21240
  • DOI: 10.1038/srep21240
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] B型肝炎ウイルス研究の進歩 (2016)
  • Author(s): 渡士幸一、脇田隆字
  • Journal Title: Pharma Medica Volume: 34 Pages: 15-18
• [Journal Article] Disparity of basal and therapeutically activated interferon signalling in constraining hepatitis E virus infection (2015)
  • Author(s): Zhou X, Xu L, Wang W, Watashi K, Wang Y, Sprengers D, de Ruiter PE, van der Laan LJ, Metselaar HJ, Kamar N, Peppelenbosch MP, Pan Q
  • Journal Title: J Viral Hepat Volume: 23 Issue: 4 Pages: 294-304
  • DOI: 10.1111/jvh.12491
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Novel Robust in Vitro Hepatitis B Virus Infection Model Using Fresh Human Hepatocytes Isolated from Humanized Mice. (2015)
  • Author(s): Ishida Y, Yamasaki C, Yanagi A, Yoshizane Y, Fujikawa K, Watashi K, Abe H, Wakita T, Hayes CN, Chayama K, Tateno C.
  • Journal Title: Am J Pathol. Volume: 185 Issue: 5 Pages: 1275-1285
  • DOI: 10.1016/j.ajpath.2015.01.028
  • Peer Reviewed
• [Journal Article] Hepatitis B Virus and Hepatitis D Virus Entry, Species Specificity, and Tissue Tropism (2015)
  • Author(s): Watashi K, Wakita T
  • Journal Title: Cold Spring Harb Perspect Med Volume: 5 Issue: 8 Pages: a021378-a021378
  • DOI: 10.1101/cshperspect.a021378
  • Peer Reviewed / Open Access
• [Journal Article] Isolation and structure of vanitaracin A, a novel anti-hepatitis B virus compound from Talaromyces sp (2015)
  • Author(s): Matsunaga H, Kamisuki S, Kaneko M, Yamaguchi Y, Takeuchi T, Watashi K, Sugawara F
  • Journal Title: Bioorg Med Chem Lett Volume: 25 Issue: 19 Pages: 4325-4328
  • DOI: 10.1016/j.bmcl.2015.07.067
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Molecular dissection of HBV evasion from restriction factor tetherin: A new perspective for antiviral cell therapy (2015)
  • Author(s): Miyakawa K, Matsunaga S, Watashi K, Sugiyama M, Kimura H, Yamamoto N, Mizokami M, Wakita T, Ryo A
  • Journal Title: Oncotarget Volume: 6 Pages: 21840-21852
  • Peer Reviewed
• [Journal Article] Amino acid polymorphisms in hepatitis C virus core affect infectious virus production and major histocompatibility complex class I molecule expression (2015)
  • Author(s): Tasaka-Fujita M, Sugiyama N, Kang W, Masaki T, Murayama A, Yamada N, Sugiyama R, Tsukuda S, Watashi K, Asahina Y, Sakamoto N, Wakita T, Shin EC, Kato T
  • Journal Title: Sci Rep Volume: 5 Issue: 1 Pages: 13994-14002
  • DOI: 10.1038/srep13994
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] A Novel Tricyclic Polyketide, Vanitaracin A, Specifically Inhibits the Entry of Hepatitis B and D Viruses by Targeting Sodium Taurocholate Cotransporting Polypeptide (2015)
  • Author(s): Kaneko M, Watashi K, Kamisuki S, Matsunaga H, Iwamoto M, Kawai F, Ohashi H, Tsukuda S, Shimura S, Suzuki R, Aizaki H, Sugiyama M, Park SY, Ito T, Ohtani N, Sugawara F, Tanaka Y, Mizokami M, Sureau C, Wakita T
  • Journal Title: J Virol Volume: 89 Issue: 23 Pages: 11945-11953
  • DOI: 10.1128/jvi.01855-15
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Identification of antiviral agents targeting hepatitis B virus promoter from extracts of Indonesian marine organisms by a novel cell-based screening assay. (2015)
  • Author(s): Yamashita A, Fujimoto Y, Tamaki M, Setiawan A, Tanaka T, Okuyama-Dobashi K, Kasai H, Watashi K, Wakita T, Toyama M, Baba M, de Voogd NJ, Maekawa S, Enomoto N, Tanaka J, Moriishi K
  • Journal Title: Marine Drug Volume: 13 Issue: 11 Pages: 6759-6773
  • DOI: 10.3390/md13116759
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Hepatitis B virus efficiently infects non-adherent hepatoma cells via human sodium taurocholate cotransporting polypeptide. (2015)
  • Author(s): Okuyama-Dobashi K, Kasai H, Tanaka T, Yamashita A, Yasumoto J, Chen W, Okamoto T, Maekawa S, Watashi K, Wakita T, Ryo A, Suzuki T, Matsuura Y, Enomoto N, Moriishi K.
  • Journal Title: Scientific reports Volume: 5 Issue: 1 Pages: 17047-17047
  • DOI: 10.1038/srep17047
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 新規B型肝炎抗ウイルス薬開発の現状 (2015)
  • Author(s): 渡士幸一、脇田隆字
  • Journal Title: カレントテラピー Volume: 33 Pages: 903-907
• [Journal Article] HBVの細胞内侵入機構とこれを標的とした創薬 (2015)
  • Author(s): 渡士幸一
  • Journal Title: 日本臨床 Volume: 73増刊号9 Pages: 372-376
• [Journal Article] B型肝炎ウイルスエントリーについて：メカニズムとその阻害 (2015)
  • Author(s): 渡士幸一、脇田隆字
  • Journal Title: 肝胆膵 Volume: 71 Pages: 1053-1058
• [Journal Article] The RNA Sensor RIG-I Dually Functions as an Innate Sensor and Direct Antiviral Factor for Hepatitis B Virus (2015)
  • Author(s): Sato S, Li K, Kameyama T, Hayashi T, Ishida Y, Murakami S, Watanabe T, Iijima S, Sakurai Y, Watashi K, Tsutsumi S, Sato Y, Akita H, Wakita T, Rice CM, Harashima H, Kohara M, Tanaka Y, Takaoka A
  • Journal Title: Immunity Volume: 42 Issue: 1 Pages: 123-132
  • DOI: 10.1016/j.immuni.2014.12.016
  • Peer Reviewed / Open Access
• [Journal Article] HBV/HDV entry, species specificity and tissue tropism (2015)
  • Author(s): Watashi K, Wakita T
  • Journal Title: Cold Spring Harb Perspect Med Volume: N/A
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Dysregulation of retinoic acid receptor diminishes hepatocyte permissiveness to hepatitis B virus infection through modulation of sodium taurocholate cotransporting polypeptide (NTCP) expression. (2015)
  • Author(s): Tsukuda S, Watashi K, Iwamoto M, Suzuki R, Aizaki H, Okada M, Sugiyama M, Kojima S, Tanaka Y, Mizokami M, Li J, Tong S, Wakita T.
  • Journal Title: J Biol Chem. Volume: 290 Issue: 9 Pages: 5673-84
  • DOI: 10.1074/jbc.m114.602540
  • Peer Reviewed / Open Access
• [Journal Article] 第6章 抗ウイルス薬 (2015)
  • Author(s): 渡士幸一
  • Journal Title: 生命科学のためのウイルス学 Volume: N/A Pages: 143-176
• [Journal Article] Formation of covalently closed circular DNA in Hep38.7-Tet cells, a tetracycline inducible hepatitis B virus expression cell line (2014)
  • Author(s): Ogura N, Watashi K, Noguchi T, Wakita T
  • Journal Title: Biochem Biophys Res Commun Volume: 452(3) Issue: 3 Pages: 315-321
  • DOI: 10.1016/j.bbrc.2014.08.029
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Alternative endocytosis pathway for productive entry of hepatitis C virus. (2014)
  • Author(s): Matsuda M, Suzuki R, Kataoka C, Watashi K, Aizaki H, Kato N, Matsuura Y, Suzuki T, Wakita T
  • Journal Title: J Gen Virol. Volume: 95(Pt 12) Issue: 12 Pages: 2658-67
  • DOI: 10.1099/vir.0.068528-0
  • Peer Reviewed / Open Access
• [Journal Article] Cyclophilin Inhibitors Reduce Phosphorylation of RNA-dependent Protein Kinase to Restore Expression of IFN-stimulated Genes in HCV-infected Cells. (2014)
  • Author(s): Daito T, Watashi K, Sluder A, Ohashi H, Nakajima S, Borroto-Esoda K, Fujita T, Wakita T.
  • Journal Title: Gastroenterology Volume: 147(2) Issue: 2 Pages: 463-72
  • DOI: 10.1053/j.gastro.2014.04.035
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 肝炎の基礎 HBV感染生活環と培養系 (2014)
  • Author(s): 渡士幸一
  • Journal Title: 肝疾患review 2014-2015 Volume: N/A Pages: 20-26
• [Journal Article] B型肝炎ウイルス感染を抑制するサイトカインの同定とその分子メカニズムの解析 (2014)
  • Author(s): 渡士幸一
  • Journal Title: Liver Forum in Kyoto 第16回学術集会記録集 Volume: N/A Pages: 13-17
• [Presentation] ヒトiPS細胞由来肝細胞のB型肝炎ウイルス in vitro 感染評価系への応用 (2017)
  • Author(s): 三谷 成二, 櫻井 文教, 山本 達郎, 高山 和雄, 立花 雅史, 渡士 幸一, 脇田 隆字, 飯島 沙幸, 田中 靖人, 水口 裕之
  • Organizer: 日本薬学会第137年会
  • Place of Presentation: 仙台
  • Year and Date: 2017-03-24
• [Presentation] B型肝炎ウイルスの侵入受容体の解析とその新規阻害剤の同定 (2017)
  • Author(s): 深野 顕人, 志村 聡美, Michael PEEL, Ann SLUDER, 河合 文啓, 九十田 千子, 鈴木 亮介, 相 崎 英樹, 朴 三用, 脇田 隆字, 小笠原 裕樹, 渡士 幸一
  • Organizer: 日本薬学会第137年会
  • Place of Presentation: 仙台
  • Year and Date: 2017-03-24
• [Presentation] Ultrastructure of hepatocytes in chronic hepatitis C patients who achieve a sustained virological response (2017)
  • Author(s): Aoyagi H, Iijima H, Puig-Basagoiti F, Zheng X, Kao YT, Hossam GE, Zaitsu T, Matsuda M, Watashi K, Suzuki R, Masaki T, Shimada N, Kato K, Tsubota A, Mimata A, Sakamaki Y, Ichinose S, Wake K, Wakita T, Aizaki H
  • Organizer: The 26th of Conference of Asian Pacific Association for the Study of the Liver, ANNUAL MEETING 2017
  • Place of Presentation: 上海
  • Year and Date: 2017-02-15
  • Int'l Joint Research
• [Presentation] Acute Hepatitis B in Japan, April 1999 ~ December 2015 (2017)
  • Author(s): Zheng X, Aoyagi H, Hossam GE, Zaitsu T, Puig-Basagoiti F, Kao YT, Watashi K, Suzuki R, Takahashi T, Sunagawa T, Oishi K, Wakita T, Aizaki H
  • Organizer: The 26th of Conference of Asian Pacific Association for the Study of the Liver, ANNUAL MEETING 2017
  • Place of Presentation: 上海
  • Year and Date: 2017-02-15
  • Int'l Joint Research
• [Presentation] B型肝炎ウイルスの培養系と創薬研究 (2017)
  • Author(s): 渡士幸一
  • Organizer: 第１９回 仙台 Liver Meeting
  • Invited
• [Presentation] Ｂ型肝炎ウイルス基礎研究・創薬研究の最近の知見 (2017)
  • Author(s): 渡士幸一
  • Organizer: 衛生微生物技術協議会第38回研究会
  • Invited
• [Presentation] トランスポーターと肝炎ウイルス (2017)
  • Author(s): 渡士幸一
  • Organizer: 日本薬物動態学会第32回年会
  • Invited
• [Presentation] B型肝炎ウイルス培養系の構築から創薬研究へ (2017)
  • Author(s): 渡士幸一
  • Organizer: 日本薬学会第138年会
  • Invited
• [Presentation] Targeting HBV-X by regulating Non-Stop mediated RNA decay (2017)
  • Author(s): Aly HH, Shiromoto F, Kato T, Watashi K, Chayama K, Wakita T
  • Organizer: 5th JAPAN-TAIWAN-KOREA HBV Research Symposium 2017
  • Int'l Joint Research
• [Presentation] Acute Hepatitis B in Japan, April 1999 ~ December 2015 (2017)
  • Author(s): Zheng X, Aoyagi H, Hossam G, Zaitsu T, Puig-Basagoiti F, Kao Y, Watashi K, Suzuki R, Takahashi T, Sunagawa T, Oishi K, Wakita T, Aizaki H
  • Organizer: 5th JAPAN-TAIWAN-KOREA HBV Research Symposium 2017
  • Int'l Joint Research
• [Presentation] Identification of HBV entry inhibitors without interfering with the NTCP transporter activity (2017)
  • Author(s): Fukano K, Shimura S, Peel M, Sluder A, Kawai F, Tsukuda S, Suzuki R, Aizaki H, Park SY, Wakita T, Ogasawara Y, Watashi K
  • Organizer: 5th JAPAN-TAIWAN-KOREA HBV Research Symposium 2017
  • Int'l Joint Research
• [Presentation] 抗HBV効果を有するNeplanocin A誘導体の作用機序解析 (2017)
  • Author(s): 外山政明, 濱崎隆之, 岡本実佳, 渡士幸一, 脇田隆字, Ashoke Sharon, 馬場昌範
  • Organizer: 第27回抗ウイルス療法学会学術集会・総会
• [Presentation] 抗肝炎ウイルス薬の薬効・変異頻度定量評価系の開発と多剤併用の意義 (2017)
  • Author(s): 渡士幸一, 小泉吉輝, 大橋啓史, 中嶋翔, 田中靖人, 脇田隆字, Alan S. Perelson, 岩見真吾
  • Organizer: 第27回抗ウイルス療法学会学術集会・総会
• [Presentation] C型慢性肝炎のウイルス学的著効（SVR）後の肝実質細胞のオルガネラ異常の解析 (2017)
  • Author(s): 青柳東代, 飯島尋子, Francesc Puig-Basagoiti, Zheng Xin, Yu Ting Kao, Gewaid E. Hossam, 在津拓馬, 松田麻未, 渡士幸一, 鈴木亮介, 政木隆博, 島田紀明, 加藤慶三, 坪田昭人, 三又絢子, 酒巻有里子, 市野瀬志津子, 和氣健二郎, 脇田隆字, 相崎英樹
  • Organizer: 第27回抗ウイルス療法学会学術集会・総会
• [Presentation] B型肝炎ウイルス培養系を用いた創薬研究 (2017)
  • Author(s): 渡士幸一、九十田千子、脇田隆字
  • Organizer: 第53回日本肝臓学会総会
• [Presentation] 胆汁酸代謝調節機構を標的としたB型肝炎ウイルス制御の試み (2017)
  • Author(s): 伊藤清顕、渡士幸一、米田政志
  • Organizer: 第53回日本肝臓学会総会
• [Presentation] HCVの肝星細胞への感染および肝星細胞活性化のメカニズム解析 (2017)
  • Author(s): 相崎英樹、渡士幸一、鈴木哲朗、政木隆博、横山寛、脇田隆字
  • Organizer: 第53回日本肝臓学会総会
• [Presentation] 1999年から2015年までの日本におけるB型急性肝炎4273症例の疫学解析 (2017)
  • Author(s): Zheng Xin, 青柳東代, Gewaid E. Hossam, 在津拓馬, Puig-Basagoiti Francesc, Yu Ting Kao, 渡士幸一, 鈴木亮介, 高橋琢理, 砂川富正, 大石和徳, 脇田隆字. 相崎英樹
  • Organizer: 第53回日本肝臓学会総会
• [Presentation] Abnormal organelles were continuously observed in sustained virological response (SVR) patients (2017)
  • Author(s): Aoyagi H, Iijima H, Puig-Basagoiti F, Zheng X, Kao YT, Gewaid HE, Zaitsu T, Matsuda M, Watashi K, Suzuki R, Masaki T, Shimada N, Kato K, Tsubota A, Mimata A, Sakamaki Y, Ichinose S, Wake K, Wakita T, Aizaki H
  • Organizer: The Asian Pacific Associaton for the Study of the Liver - Single Topic Conference 2017
  • Int'l Joint Research
• [Presentation] Acute hepatitis C virus infection among HIV-infected men who have sex with men (2017)
  • Author(s): Aoyagi H, Itoda I, Zheng X, Gewaid HE, Puig-Basagoiti F, Kao YT, Watashi K, Suzuki R, Wakita T, Aizaki H
  • Organizer: APASL Single Topic Conference 2017 Mongolia 6th HCV Conference on HCV and co-infections
  • Int'l Joint Research
• [Presentation] Sphingomyelin participates in the formation of Hepatitis C virus membrane replication vesicles (2017)
  • Author(s): Gewaid HE, Aoyagi H, Arita M, Watashi K, Suzuki R, Aly HH, Kumagai K, Yamaji T, Fukasawa M, Mimata A, Sakamaki Y, Ichinose S, Hanada K, Wakita T, Aizaki H
  • Organizer: American Society for Virology - 2017 Annual Meeting
  • Int'l Joint Research
• [Presentation] The integrity of cellular microtubule structure is important for an efficient HBV capsid formation (2017)
  • Author(s): Iwamoto M, Cai D, Sugiyama M, Suzuki R, Aizaki H, Ryo A, Ohtani N, Tanaka Y, Mizokami M, Wakita T, Guo H, Watashi K
  • Organizer: 2017 International HBV Meeting The Molecular Biology of Hepatitis B Viruses
  • Int'l Joint Research
• [Presentation] Supporting evidence that HBV virions bud mainly through the ER/ERGIC membranes (2017)
  • Author(s): Hotta H, Chen M, Aoki-Utsubo C, Deng L, Watashi K, Wakita T
  • Organizer: 2017 International HBV Meeting The Molecular Biology of Hepatitis B Viruses
  • Int'l Joint Research
• [Presentation] HBV-X and the balance between degradation or inflammation (2017)
  • Author(s): Aly HH, Shiromoto F, Watashi K, Hoshino S, Kato T, Chayama K, Wakita T
  • Organizer: 2017 International HBV Meeting The Molecular Biology of Hepatitis B Viruses
  • Int'l Joint Research
• [Presentation] SLC10A1/NTCPのトラフィッキング制御を標的とした新規B型肝炎ウイルス感染阻害戦略 (2017)
  • Author(s): 深野顕人, 九十田千子, 鈴木亮介, 相崎英樹, 村松正道, 脇田隆字, 小笠原裕樹, 渡士幸一
  • Organizer: 日本薬学会第138年会
• [Presentation] HBV exploit Ski2/RNA complex to degrade cytokines and suppress inflammation (2017)
  • Author(s): Aly HH, Shiromoto F, Watashi K, Kato T, Chayama K, Wakita T
  • Organizer: The 65th Annual Meeting of the Japanese Society for Virology
• [Presentation] Membrane protein, embryonic lethal, abnormal vision, drosophila-like 1, interacts with NS5A and involves in hepatitis C virus replication (2017)
  • Author(s): Kao YT, Goto K, Aoyagi H, Hossam GE, Zheng X, Puig-Basagoiti F, Watashi K, Suzuki R, Yamagoe S, Dohmae N, Suzuki T, Okushin K, Tsutsumi T, Yotsuyanagi H, Moriya K, Koike K, Suzuki T, Wakita T, Aizaki H
  • Organizer: The 65th Annual Meeting of the Japanese Society for Virology
• [Presentation] The bidirectional interplay of hepatitis B virus and cell-death inducing DFF45-like effectors (2017)
  • Author(s): Kasai H, Yasumoto J, Yamashita A, Tanaka T, Watashi K, Wakita T, Otoguro T, Moriishi K
  • Organizer: The 65th Annual Meeting of the Japanese Society for Virology
• [Presentation] Novel crosstalk of Xenobiotic Response with Lipid Biosynthesis Pathway regulates the Host Permissiveness to the Hepatitis C Virus Production (2017)
  • Author(s): Ohashi H, Nakajima S, Kim S, Fukasawa M, Suzuki R, Aizaki H, Sugawara F, Ohtani N, Wakita T, Watashi K
  • Organizer: The 65th Annual Meeting of the Japanese Society for Virology
• [Presentation] Identification of a hepatitis B virus internalization inhibitor with a novel mode of action (2017)
  • Author(s): Fukano K, Tsukuda S, Suzuki R, Aizaki H, Wakita T, Ogasawara Y, Watashi K
  • Organizer: The 65th Annual Meeting of the Japanese Society for Virology
• [Presentation] Interaction of hepatitis B virus core protein with microtubles is important for the efficient capsid formation (2017)
  • Author(s): Iwamoto M, Cai D, Sugiyama M, Suzuki R, Aizaki H, Ryo A, Ohtani N, Tanaka Y, Mizokami M, Wakita T, Watashi K
  • Organizer: The 65th Annual Meeting of the Japanese Society for Virology
• [Presentation] Phosphorylation of protein kinase R and translational suppression by NS5B protein of hepatitis C virus (2017)
  • Author(s): Suzuki R, Matsuda M, Shimoike T, Watashi K, Aizaki H, Kato T, Suzuki T, Wakita T
  • Organizer: The 65th Annual Meeting of the Japanese Society for Virology
• [Presentation] Generation of hepatitis C virus vaccine antigen based on Japanese encephalitis virus subviral particles (2017)
  • Author(s): Yato K, Matsuda M, Watanabe N, Nakajima S, Fujimoto A, Watashi K, Aizaki H, Kato T, Tamura K, Wakita T, Suzuki R
  • Organizer: The 65th Annual Meeting of the Japanese Society for Virology
• [Presentation] Establishment of quantification method for the efficacy of anti-hepatitis virus combination treatments (2017)
  • Author(s): Watashi K, Koizumi Y, Ohashi H, Nakajima S, Tanaka Y, Wakita T, Perelson AS, Iwami S
  • Organizer: The 65th Annual Meeting of the Japanese Society for Virology
• [Presentation] NTCPを利用したHBV創薬研究およびNTCPを介したHBV侵入機構の解析 (2017)
  • Author(s): 九十田千子, 渡士幸一, 小嶋聡一, 脇田隆字
  • Organizer: 2017年度 生命科学系合同年次大会
  • Invited
• [Presentation] Involvement of cell-death inducing DFF45-like effectors in HBV replication (2017)
  • Author(s): Yasumoto J, Kasai H, Yoshimura K, Otoguro T, Watashi K, Wakita T, Yamashita A, Tanaka T, Takeda S, Moriishi K
  • Organizer: 5th JAPAN-TAIWAN-KOREA HBV Research Symposium 2017
  • Int'l Joint Research
• [Presentation] Hepatitis B virus capsid formation is regulated by microtubules and their posttranslational modification (2017)
  • Author(s): Iwamoto M, Sugiyama M, Suzuki R, Aizaki H, Tanaka Y, Mizokami M, Ohtani N, Wakita T, Watashi K
  • Organizer: 5th JAPAN-TAIWAN-KOREA HBV Research Symposium 2017
  • Int'l Joint Research
• [Presentation] B型肝炎ウイルスの内在化阻害剤の同定 (2017)
  • Author(s): Fukano K, Tsukuda S, Suzuki R, Aizaki H, Wakita T, Ogasawara Y, Watashi K
  • Organizer: 第14回ウイルス学キャンプin湯河原
• [Presentation] Chemical array system for identifying anti-hepatitis B virus entry inhibitors (2017)
  • Author(s): 九十田千子, 金子学, 渡士幸一, 小嶋聡一, 脇田隆字
  • Organizer: 第14回ウイルス学キャンプin湯河原
• [Presentation] Crosstalk of Xenobiotic Metabolism Pathway with Lipid Metabolism regulates the Host Permissiveness to Hepatitis C Virus Production (2017)
  • Author(s): Ohashi H, Nakajima S, Kim S, Suzuki R, Aizaki H, Fukasawa M, Kamisuki S, Sugawara F, Ohtani N, Wakita T, Watashi K
  • Organizer: 第14回ウイルス学キャンプin湯河原
• [Presentation] 培養細胞を用いたB型肝炎ウイルス cccDNAの動態解析 (2017)
  • Author(s): Iwamoto M, Kakizoe Y, Iwami S, Watashi K
  • Organizer: 第14回ウイルス学キャンプin湯河原
• [Presentation] Antiviral effect of bile acid derivatives on hepatitis B virus infection (2017)
  • Author(s): Okumura A, Ito K, Watashi K, Takeuchi J, Inoue R, Suzuki S, Sakamoto K, Okutsu S, Umezawa K, Wakita T, Yoneda M
  • Organizer: 2017 International HBV Meeting The Molecular Biology of Hepatitis B Viruses
  • Int'l Joint Research
• [Presentation] Modulation of HBV life cycle by sulforaphane (2017)
  • Author(s): Okamura H, Sasai M, Nio Y, Watashi K, Wakita T, Hijikata M
  • Organizer: 2017 International HBV Meeting The Molecular Biology of Hepatitis B Viruses
  • Int'l Joint Research
• [Presentation] Fatty acids with certain carbon chain length can support hepatitis B virus production (2017)
  • Author(s): Okamura H, Nio Y, Watashi K, Wakita T, Hijikata M
  • Organizer: 2017 International HBV Meeting The Molecular Biology of Hepatitis B Viruses
  • Int'l Joint Research
• [Presentation] An Epidemiology Study of Acute Hepatitis B in Japan, April 1999 ~ December 2015 (2017)
  • Author(s): Zheng X, Aoyagi H, Hossam G, Zaitsu T, Puig-Basagoiti F, Kao Y, Watashi K, Suzuki R, Takahashi T, Sunagawa T, Oishi K, Wakita T, Aizaki H
  • Organizer: 2017 International HBV Meeting The Molecular Biology of Hepatitis B Viruses
  • Int'l Joint Research
• [Presentation] Structural Proteins of Hepatitis C virus Genotype 3a S310 Strain Permit Claudin-1- independent Entry (2017)
  • Author(s): Suzuki R, Yato K, Tosaka T, Hmwe SS, Matsuda M, Watashi K, Aizaki H, Fukasawa M, Matsuura Y, Wakita T
  • Organizer: 24th International Symposium on Hepatitis C Virus and Related Viruses
  • Int'l Joint Research
• [Presentation] NS5A-Associated Membrane Protein, Embryonic Lethal, Abnormal Vision, Drosophila-Like 1, Involves in Hepatitis C Replication (2017)
  • Author(s): Kao YT, Goto K, Aoyagi H, Hossam GE, Zheng X, Puig-Basagoiti F, Watashi K, Suzuki R, Yamagoe S, Dohmae N, Suzuki T, Okushin K, Tsutsumi T, Yotsuyanagi H, Moriya K, Koike K, Suzuki T, Wakita T, Aizaki H
  • Organizer: 24th International Symposium on Hepatitis C Virus and Related Viruses
  • Int'l Joint Research
• [Presentation] Novel Crosstalk of Xenobiotic Response with Lipid Metabolism Regulates the Host Permissiveness to Hepatitis C Virus Production (2017)
  • Author(s): Ohashi H, Nakajima S, Kim S, Suzuki R, Aizaki H, Fukasawa M, Kamisuki S, Sugawara F, Ohtani N, Wakita T, Watashi K
  • Organizer: 24th International Symposium on Hepatitis C Virus and Related Viruses
  • Int'l Joint Research
• [Presentation] Broad antiviral activities of acidic polysaccharides isolated from marine algae (2017)
  • Author(s): Ueno M, Nogawa M, Siddiqui R, Watashi K, Wakita T, Kato T, Oda T, Ariumi Y
  • Organizer: The 65th Annual Meeting of the Japanese Society for Virology
• [Presentation] Analysis of HBV life cycle in the HepG2 expressing human NTCP cell line (2017)
  • Author(s): Rahayu R, Ohsaki E, Honda T, Okamoto T, Watashi K, Ueda K
  • Organizer: The 65th Annual Meeting of the Japanese Society for Virology
• [Presentation] 50.Fatty acids synthesized from cellular fatty acid synthesis pathway play roles in hepatitis B virus production (2017)
  • Author(s): Okamura H, Nio Y, Watashi K, Wakita T, Hijikata M
  • Organizer: The 65th Annual Meeting of the Japanese Society for Virology
• [Presentation] Human hepatic stellate cells are permissive for hepatitis C virus infection/replication and play important roles in fibrosis (2017)
  • Author(s): Zheng X, Zaitsu T, Aoyagi H, Matsuda M, Watanabe N, Fujimoto A, Watashi K, Suzuki R, Fukuhara T, Matsuura Y, Ichinose S, Wake K, Suzuki T, Iijima H, Yokoyama H, Masaki T, Matsuura T, Tamura K, Wakita T, Aizaki H
  • Organizer: The 65th Annual Meeting of the Japanese Society for Virology
• [Presentation] Abnormal hepatocellular organelles remain to be observed in sustained virological response patients (2017)
  • Author(s): Aoyagi H, Iijima H, Puig-Basagoiti F, Zheng X, Kao YT, Hossam GE, Matsuda M, Watashi K, Suzuki R, Masaki T, Aizawa N, Shimada N, Kato K, Tsubota A, Mimata A, Sakamaki Y, Ichinose S, Wake K, Wakita T, Aizaki H
  • Organizer: The 65th Annual Meeting of the Japanese Society for Virology
• [Presentation] Screening of FDA-approved drugs activating cyclic GMP-AMP synthase promoter (2017)
  • Author(s): Imai H, Dansako H, Ueda Y, Satoh S, Watashi K, Wakita T, Kato N
  • Organizer: The 65th Annual Meeting of the Japanese Society for Virology
• [Presentation] Establishment of a neutralization assay for multiple flaviviruses based on single-round infectious particles (2017)
  • Author(s): Matsuda M, Yamanaka A, Yoshii K, Watashi K, Aizaki H, Konishi E, Takasaki T, Wakita T, Suzuki R
  • Organizer: The 65th Annual Meeting of the Japanese Society for Virology
• [Presentation] Identification of a new class of HBV and HDV entry inhibitor, proanthocyanidin (2017)
  • Author(s): Tsukuda S, Watashi K, Kojima S, Wakita T
  • Organizer: AASLD The Liver Meeting 2017
  • Int'l Joint Research
• [Presentation] Mechanism of HBV entry and the role of NTCP (2016)
  • Author(s): Watashi K
  • Organizer: APASL Single Topic Conference (STC) - 6th HBV Conference
  • Place of Presentation: 北京
  • Year and Date: 2016-12-16
  • Int'l Joint Research / Invited
• [Presentation] B型肝炎ウイルス侵入過程を標的とした創薬研究 (2016)
  • Author(s): 渡士幸一、九十田千子、脇田隆字
  • Organizer: 第41回日本肝臓学会東部会
  • Place of Presentation: 東京
  • Year and Date: 2016-12-08
• [Presentation] Protein kinase C triggers the internalization of hepatitis B and D viruses into hepatocytes (2016)
  • Author(s): Iwamoto M, Kaneko M, Ohashi H, Kawai F, Suzuki R, Aizaki H, Park SY, Ryo A, Ohtani N, Wakita T, Watashi K
  • Organizer: The 64th Annual Meeting of the Japanese Society for Virology
  • Place of Presentation: 札幌
  • Year and Date: 2016-10-23
• [Presentation] Strategy for hepatitis B and D virus entry inhibition without impairing NTCP-mediated bile acid uptake (2016)
  • Author(s): Watashi K, Shimura S, Peel M, Sluder A, Kawai F, Iwamoto M, Tsukuda S, Suzuki R, Aizaki H, Sugiyama M, Park SY, Tanaka Y, Mizokami M, Wakita T
  • Organizer: The 64th Annual Meeting of the Japanese Society for Virology
  • Place of Presentation: 札幌
  • Year and Date: 2016-10-23
• [Presentation] Fatty acid biosynthesis specifically regulates hepatitis B virus particle production (2016)
  • Author(s): Okamura H, Akahori Y, Nio Y, Watashi K, Wakita T, Hijikata M
  • Organizer: The 64th Annual Meeting of the Japanese Society for Virology
  • Place of Presentation: 札幌
  • Year and Date: 2016-10-23
• [Presentation] Non-Stop mediated RNA decay mechanism targets HBV-X mRNA for degradation at the RNA exosome (2016)
  • Author(s): Aly H, Watashi K, Chayama K, Hijikata M, Wakita T
  • Organizer: The 64th Annual Meeting of the Japanese Society for Virology
  • Place of Presentation: 札幌
  • Year and Date: 2016-10-23
• [Presentation] Development of novel hepatitis B virus culture system using immortalized human hepatocytes (2016)
  • Author(s): Akahori Y, Kato H, Fujita T, Moriishi K, Watashi K, Wakita T, Hijikata M
  • Organizer: The 64th Annual Meeting of the Japanese Society for Virology
  • Place of Presentation: 札幌
  • Year and Date: 2016-10-23
• [Presentation] ISG20 inhibits HBV replication by accelerating decay of HBV genome (2016)
  • Author(s): Funami K, Leong CR, Oshiumi H, Okamoto M, Takaki H, Matsumoto M, Chayama K, Watashi K, Seya T
  • Organizer: The 64th Annual Meeting of the Japanese Society for Virology
  • Place of Presentation: 札幌
  • Year and Date: 2016-10-23
• [Presentation] Development of a neutralization assay for multiple flaviviruses based on single-round infectious particles (2016)
  • Author(s): Matsuda M, Yamanaka A, Yoshii K, Watashi K, Aizaki H, Konishi E, Takasaki T, Wakita T, Suzuki R
  • Organizer: The 64th Annual Meeting of the Japanese Society for Virology
  • Place of Presentation: 札幌
  • Year and Date: 2016-10-23
• [Presentation] Characterization of origomeric flavonoids as a novel class of anti-HBV entry inhibitors that directly target viral envelope protein (2016)
  • Author(s): Tsukuda S, Watashi K, Hojima T, Isogawa M, Suzuki R, Aizaki H, Kojima S, Sugiyama M, Saito A, Tanaka Y, Mizokami M, Wakita T
  • Organizer: The 64th Annual Meeting of the Japanese Society for Virology
  • Place of Presentation: 札幌
  • Year and Date: 2016-10-23
• [Presentation] Aryl hydrocarbon receptor regulates the assembly of hepatitis C virus and affects the emergence of drug resistant virus against DAAs (2016)
  • Author(s): Ohashi H, Syo Nakajima, Sulyi Kim, Suzuki R, Aizaki H, Fukasawa M, Kamisuki S, Sugawara F, Ohtani N, Wakita T, Watashi K
  • Organizer: The 64th Annual Meeting of the Japanese Society for Virology
  • Place of Presentation: 札幌
  • Year and Date: 2016-10-23
• [Presentation] Analysis of the HBV life cycle in a HepG2 expressing human NTCP (2016)
  • Author(s): Rahayu R, Ohsaki E, Okamoto T, Watashi K, Ueda K
  • Organizer: The 64th Annual Meeting of the Japanese Society for Virology
  • Place of Presentation: 札幌
  • Year and Date: 2016-10-23
• [Presentation] Sphingomyelin is a component in the membranous replication factories (2016)
  • Author(s): Gewaid HE, Aoyagi H, Watashi K, Suzuki R, Aly HH, Kumajai K, Yamaji T, Fukasawa M, Mimata A, Sakamaki Y, Ichinose S, Hanada K, Wakita T, Aizaki H
  • Organizer: 23rd International Symposium on Hepatitis C Virus and Related Viruses
  • Place of Presentation: 京都
  • Year and Date: 2016-10-11
  • Int'l Joint Research
• [Presentation] The HCV cell culture system identified fungal-derived neoechinulin B as a novel antagonist of liver X receptor (2016)
  • Author(s): Watashi K, Nakajima S, Ohashi H, Kamisuki S, Kwon ATJ, Suzuki H, Tsukuda S, Suzuki R, Aizaki H, Kato T, Sugawara F, Wakita T
  • Organizer: 23rd International Symposium on Hepatitis C Virus and Related Viruses
  • Place of Presentation: 京都
  • Year and Date: 2016-10-11
  • Int'l Joint Research
• [Presentation] Vanitaracin A is a novel entry inhibitor of hepatitis B and D viruses through targeting NTCP (2016)
  • Author(s): Kaneko M, Watashi K, Kamisuki S, Iwamoto M, Tsukuda S, Ohashi H, Kawai F, Mizokami M, Park SY, Tanaka Y, Suzuki R, Aizaki H, Sugawara F, Otani N, Wakita T
  • Organizer: 23rd International Symposium on Hepatitis C Virus and Related Viruses
  • Place of Presentation: 京都
  • Year and Date: 2016-10-11
  • Int'l Joint Research
• [Presentation] Retinoid inhibitors abolish the host permissiveness to hepatitis B virus infection by modulating the expression of NTCP (2016)
  • Author(s): Tsukuda S, Watashi K, Iwamoto M, Suzuki R, Aizaki H, Kojima S, Sugiyama M, Tanaka Y, Mizokami M, Wakita T
  • Organizer: 23rd International Symposium on Hepatitis C Virus and Related Viruses
  • Place of Presentation: 京都
  • Year and Date: 2016-10-11
  • Int'l Joint Research
• [Presentation] Establishment of the method for evaluating molecular interaction between hepatitis B virus entry inhibitors and sodium taurocholate cotransporting polypeptide (2016)
  • Author(s): Fukano K, Shimura S, Peel M, Sluder A, Kawai F, Tsukuda S, Suzuki R, Aizaki H, Park SY, Wakita T, Ogasawara Y, Watashi K
  • Organizer: 23rd International Symposium on Hepatitis C Virus and Related Viruses
  • Place of Presentation: 京都
  • Year and Date: 2016-10-11
  • Int'l Joint Research
• [Presentation] Non-Stop mediated RNA decay mechanism regulates Hepatitis B virus replication (2016)
  • Author(s): Aly HH, Watashi K, Chayama K, Wakita T
  • Organizer: 23rd International Symposium on Hepatitis C Virus and Related Viruses
  • Place of Presentation: 京都
  • Year and Date: 2016-10-11
  • Int'l Joint Research
• [Presentation] Role of lipid droplets in the emergence of drug resistant virus against direct acting antivirals (2016)
  • Author(s): Ohashi H, Nakajima S, Kim S, Suzuki R, Aizaki H, Fukasawa F, Kamisuki S, Sugawara F, Ohtani N, Wakita T, Watashi K
  • Organizer: 23rd International Symposium on Hepatitis C Virus and Related Viruses
  • Place of Presentation: 京都
  • Year and Date: 2016-10-11
  • Int'l Joint Research
• [Presentation] Hepatitis B virus capsid formation is regulated by microtubules and their posttranslational modification (2016)
  • Author(s): Iwamoto M, Sugiyama M, Suzuki R, Aizaki H, Tanaka Y, Mizokami M, Ohtani N, Wakita T, Watashi K
  • Organizer: 23rd International Symposium on Hepatitis C Virus and Related Viruses
  • Place of Presentation: 京都
  • Year and Date: 2016-10-11
  • Int'l Joint Research
• [Presentation] Development of Novel Anti-viral Agents against Hepatitis B Virus by using an siRNA Screening Panel Targeting the Carbohydrate Synthesis System (2016)
  • Author(s): Ito K, Yoneda M, Angata K, Watashi K, Wakita T, Tanaka Y, Mizokami M, Narimatsu H
  • Organizer: 23rd International Symposium on Hepatitis C Virus and Related Viruses
  • Place of Presentation: 京都
  • Year and Date: 2016-10-11
  • Int'l Joint Research
• [Presentation] Human hepatic stellate cells are permissive for hepatitis C virus infection/replication and play important roles in fibrosis (2016)
  • Author(s): Zaitsu T, Aoyagi H, Matsuda M, Watanabe N, Fujimoto A, Watashi K, Suzuki R, Fukuhara T, Matsuura M, Wake K, Suzuki T, Matsuura T, Tamura K, Wakita T, Aizaki H
  • Organizer: 23rd International Symposium on Hepatitis C Virus and Related Viruses
  • Place of Presentation: 京都
  • Year and Date: 2016-10-11
  • Int'l Joint Research
• [Presentation] Activation of protein kinase R by hepatitis C virus RNA-dependent RNA polymerase (2016)
  • Author(s): Suzuki R, Matsuda M, Shimoike T, Watashi K, Aizaki H, Kato T, Suzuki T, Wakita T
  • Organizer: 23rd International Symposium on Hepatitis C Virus and Related Viruses
  • Place of Presentation: 京都
  • Year and Date: 2016-10-11
  • Int'l Joint Research
• [Presentation] Multiple flaviviruses neutralization assay based on single-round infectious particles (2016)
  • Author(s): Matsuda M, Yamanaka A, Yoshii K, Watashi K, Aizaki H, Konishi E, Takasaki T, Wakita T, Suzuki R
  • Organizer: 23rd International Symposium on Hepatitis C Virus and Related Viruses
  • Place of Presentation: 京都
  • Year and Date: 2016-10-11
  • Int'l Joint Research
• [Presentation] Strategy for hepatitis B and D virus entry inhibition without affecting bile acid transport (2016)
  • Author(s): Watashi K, Shimura S, Peel M, Sluder A, Kawai F, Iwamoto M, Tsukuda S, Suzuki R, Aizaki H, Sugiyama M, Park SY, Tanaka Y, Mizokami M, Wakita T
  • Organizer: 2016 International HBV Meeting The Molecular Biology of Hepatitis B Viruses
  • Place of Presentation: ソウル
  • Year and Date: 2016-09-21
  • Int'l Joint Research
• [Presentation] Proanthocyanidin and its analogs are new class of HBV and HDV entry inhibitors that target the viral preS1 region (2016)
  • Author(s): Tsukuda S, Watashi K, Hojima T, Isogawa M, Iwamoto M, Suzuki R, Aizaki H, Kojima S, Sugiyama M, Saito A, Tanaka Y, Mizokami M, Wakita T
  • Organizer: 2016 International HBV Meeting The Molecular Biology of Hepatitis B Viruses
  • Place of Presentation: ソウル
  • Year and Date: 2016-09-21
  • Int'l Joint Research
• [Presentation] Development of Novel Anti-viral Agents against Hepatitis B Virus by using an siRNA Screening Panel Targeting the Carbohydrate Synthesis (2016)
  • Author(s): Ito K, Yoneda M, Angata K, Watashi K, Wakita T, Tanaka Y, Tong S, Mizokami M, Narimatsu H
  • Organizer: 2016 International HBV Meeting The Molecular Biology of Hepatitis B Viruses
  • Place of Presentation: ソウル
  • Year and Date: 2016-09-21
  • Int'l Joint Research
• [Presentation] A novel Neplanocin A derivatives selectively inhibit HBV replication (2016)
  • Author(s): Toyama M, Hamasaki T, Okamoto M, Ikeda M, Watashi K, Wakita T, Yamashita A, Moriishi K, Sharon A, Baba M
  • Organizer: 2016 International HBV Meeting The Molecular Biology of Hepatitis B Viruses
  • Place of Presentation: ソウル
  • Year and Date: 2016-09-21
  • Int'l Joint Research
• [Presentation] The cell line derived from immortalized human hepatocytes was highly susceptible to blood-borne hepatitis B virus in the three-dimensional culture condition (2016)
  • Author(s): Akahori Y, Kato H, Fujita T, Moriishi K, Watashi K, Wakita T, Hijikata M
  • Organizer: 2016 International HBV Meeting The Molecular Biology of Hepatitis B Viruses
  • Place of Presentation: ソウル
  • Year and Date: 2016-09-21
  • Int'l Joint Research
• [Presentation] Induction of NTCP expression in a human HCC cell line by retinoic acid and its possible effect on host susceptibility to HBV infection (2016)
  • Author(s): Masaki T, Matsumoto Y, Aizaki H, Nagamori shushi, Watashi K, Park J, Kanai Y, Kojima S, Wakita T, Matsuura T
  • Organizer: 2016 International HBV Meeting The Molecular Biology of Hepatitis B Viruses
  • Place of Presentation: ソウル
  • Year and Date: 2016-09-21
  • Int'l Joint Research
• [Presentation] Non-Stop mediated RNA quality control decay regulates HBV X-mRNA (2016)
  • Author(s): Aly HH, Suzuki J, Watashi K, Hijikata M, Kato T, Chayama K, Wakita T
  • Organizer: 2016 International HBV Meeting The Molecular Biology of Hepatitis B Viruses
  • Place of Presentation: ソウル
  • Year and Date: 2016-09-21
  • Int'l Joint Research
• [Presentation] DDX3 and INI1/hSNF5 restrict HBV replication through alteration of subcellular localization of HBx (2016)
  • Author(s): Ariumi Y, Watashi K, Wakita T
  • Organizer: 2016 International HBV Meeting The Molecular Biology of Hepatitis B Viruses
  • Place of Presentation: ソウル
  • Year and Date: 2016-09-21
  • Int'l Joint Research
• [Presentation] Protein kinase C triggers the internalization of hepatitis B and D viruses into hepatocytes (2016)
  • Author(s): Iwamoto M, Kaneko M, Ohashi H, Kawai F, Suzuki R, Aizaki H, Park SY, Ryo A, Ohtani N, Wakita T, Watashi K
  • Organizer: 第13回ウイルス学キャンプ in 湯河原
  • Place of Presentation: 湯河原
  • Year and Date: 2016-08-30
• [Presentation] Aryl hydrocarbon receptorのC型肝炎ウイルス感染応答における役割・分子メカニズムの解析 (2016)
  • Author(s): Ohashi H, Nakajima S, Kim S, Suzuki R, Aizaki H, Fukasawa M, Kamisuki S, Sugawara F, Ohtani N, WakitaT, Watashi K
  • Organizer: 第13回ウイルス学キャンプ in 湯河原
  • Place of Presentation: 湯河原
  • Year and Date: 2016-08-30
• [Presentation] 細胞培養系を用いた新規抗B型肝炎ウイルス化合物の同定 (2016)
  • Author(s): Kaneko M, Watashi K, Iwamoto M, Kamisuki S, Matsunaga H, Iwamoto M, Kawai F, Ohashi H, Tsukuda S, Shimura S, Suzuki R, Aizaki H, Sugiyama M, Park SY, Ito T, Ohtani N, Sugawara F, Tanaka Y, Mizokami M, Sureau C, Wakita T
  • Organizer: 第13回ウイルス学キャンプ in 湯河原
  • Place of Presentation: 湯河原
  • Year and Date: 2016-08-30
• [Presentation] B型肝炎ウイルスの適応進化メカニズム解析 (2016)
  • Author(s): 竹内（柴田）潤子、 岩本将士、 渡士幸一
  • Organizer: 第13回ウイルス学キャンプ in 湯河原
  • Place of Presentation: 湯河原
  • Year and Date: 2016-08-30
• [Presentation] 低分子化合物を用いたB型肝炎ウイルスの感染感受性決定機構の解析 (2016)
  • Author(s): Tsukuda S, Watashi K, Iwamoto M, Suzuki R, Aizaki H, Kojima S, Wakita T
  • Organizer: 第13回ウイルス学キャンプ in 湯河原
  • Place of Presentation: 湯河原
  • Year and Date: 2016-08-30
• [Presentation] B型肝炎ウイルスの侵入受容体阻害剤の同定とその機序の解析 (2016)
  • Author(s): Fukano K, Shimura S, Peel M, Sluder A, Kawai F, Tsukuda S, Suzuki R, Aizaki H, Park SY, Wakita T, Ogasawara Y, Watashi K
  • Organizer: 第13回ウイルス学キャンプ in 湯河原
  • Place of Presentation: 湯河原
  • Year and Date: 2016-08-30
• [Presentation] 肝炎ウイルス研究の現状と、抗ウイルス創薬研究 (2016)
  • Author(s): 渡士幸一
  • Organizer: Summer Retrovirus Conference (SRC) 2016
  • Place of Presentation: 京都
  • Year and Date: 2016-07-07
  • Invited
• [Presentation] B型肝炎ウイルスを標的とした新規侵入阻害剤の同定と作用機序の解析 (2016)
  • Author(s): 九十田千子、渡士幸一、小嶋聡一、脇田隆字
  • Organizer: 第52回日本肝臓学会総会
  • Place of Presentation: 幕張
  • Year and Date: 2016-05-19
• [Presentation] 新規作用機序を有するB型肝炎ウイルス創薬 (2016)
  • Author(s): 渡士幸一、九十田千子、脇田隆字
  • Organizer: 第52回日本肝臓学会総会
  • Place of Presentation: 幕張
  • Year and Date: 2016-05-19
• [Presentation] 脂肪酸生合成経路の阻害によるHBV粒子の産生抑制機構の解析 (2016)
  • Author(s): 岡村瞳、赤堀祐一、金ソルイ、渡士幸一、脇田隆字、土方誠
  • Organizer: 第26回抗ウイルス療法学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2016-05-13
• [Presentation] ピリミドトリアジノン誘導体の抗HBV効果について (2016)
  • Author(s): 外山政明、濱崎隆之、岡本実佳、渡士幸一、脇田隆字、馬場昌範
  • Organizer: 第26回抗ウイルス療法学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2016-05-13
• [Presentation] B型肝炎ウイルス粒子を直接標的とする侵入阻害剤proanthocyanidin (2016)
  • Author(s): 九十田千子、渡士幸一、濱田義知、齊藤安貴子、五十川正記、田中義正、鈴木亮介、相崎英樹、小嶋聡一、杉山真也、田中靖人、溝上雅史、脇田隆字
  • Organizer: 第26回抗ウイルス療法学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2016-05-13
• [Presentation] 立体培養したHBV受容体hNTCP発現不死化ヒト肝細胞による新たなHBV培養系を用いた抗HBV薬評価系の構築 (2016)
  • Author(s): 赤堀祐一、加藤博己、藤田尚志、森石恆司、渡士幸一、脇田隆字、土方誠
  • Organizer: 第26回抗ウイルス療法学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2016-05-13
• [Presentation] HCVに対する抗ウイルス治療後、SVR後の肝細胞の超微細構造の変化 (2016)
  • Author(s): 青柳東代、飯島尋子、松田麻未、渡士幸一、鈴木亮介、政木隆博、坂巻有里子、市野瀬志津子、坪田昭人、和氣健二郎、脇田隆字、相崎英樹
  • Organizer: 第26回抗ウイルス療法学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2016-05-13
• [Presentation] B型肝炎ウイルス感染を阻害する新規macrocyclesの同定と、NTCP依存性胆汁酸取り込み抑制能を欠失した選択的阻害剤の創出 (2016)
  • Author(s): 渡士幸一、志村聡美、Michael Peel、Ann Sluder、河合文啓、岩本将士、杉山真也、朴三用、田中靖人、溝上雅史、脇田隆字
  • Organizer: 第26回抗ウイルス療法学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2016-05-13
• [Presentation] Precore stop codon regulates the stability of HBV X-mRNA (2016)
  • Author(s): Aly HH, Suzuki J, Watashi K, Chayama K, Wakita T
  • Organizer: 4th Taiwan-Korea-Japan Research Symposium on Hepatitis B Virus
  • Place of Presentation: 台北
  • Year and Date: 2016-04-09
  • Int'l Joint Research
• [Presentation] Inhibition of HBV entry process through targeting host and viral molecules (2016)
  • Author(s): Tsukuda S, Watashi K, Hamada Y, Isogawa M, Iwamoto M, Suzuki R, Aizaki H, Kojima S, Sugiyama M, Saito A, Tanaka Y, Mizokami M, Wakita T
  • Organizer: 4th Taiwan-Korea-Japan Research Symposium on Hepatitis B Virus
  • Place of Presentation: 台北
  • Year and Date: 2016-04-09
  • Int'l Joint Research
• [Presentation] 肝炎ウイルスの創薬研究 (2016)
  • Author(s): 渡士幸一
  • Organizer: 京都大学ウイルス研究所セミナー, ウイルス研究の潮流シリーズ
  • Place of Presentation: 京都
  • Invited
• [Presentation] Cyclosporin A and its analogs inhibit hepatitis B virus entry into cultured hepatocytes through targeting a membrane transporter, sodium taurocholate cotransporting polypeptide (NTCP) (2016)
  • Author(s): 渡士幸一
  • Organizer: 第29回肝臓フォーラム（東部）
  • Place of Presentation: 東京
  • Invited
• [Presentation] 肝炎ウイルスの基礎研究から創薬研究へ (2016)
  • Author(s): 渡士幸一
  • Organizer: 明治薬科大学セミナー
  • Place of Presentation: 東京
  • Invited
• [Presentation] A novel tricyclic polyketide, vanitaracin A, specifically inhibits the entry of hepatitis B and D viruses through targeting NTCP (2016)
  • Author(s): Kaneko M, Watashi K, Kamisuki S, Matsunaga H, Iwamoto M, Kawai F, Ohashi H, Tsukuda S, Shimura S, Suzuki R, Aizaki H, Sugiyama M, Sam-Yong Park, Ito T, Ohtani N, Sugawara F, Tanaka Y, Mizokami M, Sureau C, Wakita T
  • Organizer: 東京理科大学イメージングフロンティアセンターシンポジウム
  • Place of Presentation: 野田
• [Presentation] Hepatitis C virus cell culture system identifies fungi-derived NeoB as a liver X receptor inhibitor (2015)
  • Author(s): Watashi K
  • Organizer: Pacifichem 2015
  • Place of Presentation: Honolulu
  • Year and Date: 2015-12-16
  • Int'l Joint Research
• [Presentation] 海綿由来セキステルペン系化合物metachromin AのB型肝炎ウイルスコアプロモーター抑制活性を介した抗ウイルス活性 (2015)
  • Author(s): 山下篤哉, 田中智久, 土橋香織, 葛西宏威, 渡士幸一, 脇田隆字, 外山正明, 馬場昌範, 前川伸哉, 榎本信幸, 玉城麻友美, 田中淳一, 森石恆司
  • Organizer: BMB 2015
  • Place of Presentation: 神戸
  • Year and Date: 2015-12-02
• [Presentation] Development of a novel vaccine platform based on Japanese encephalitis viruses (2015)
  • Author(s): Suzuki R, Saga R, Fujimoto A, Watanabe N, Matsuda M, Hasegawa M, Watashi K, Aizaki H, Nakamura N, Konishi E, Kato T, Tajima S, Takasaki T, Takeyama H, Wakita T
  • Organizer: BMB 2015
  • Place of Presentation: 神戸
  • Year and Date: 2015-12-02
• [Presentation] Development ofa cell culture and infection system for hepatitis B virus using 3D cultured non-neoplasmic HuS-E/2 cells (2015)
  • Author(s): Akahori Y, Kato H, Fujita T, Moriishi K, Watashi K, Wakita T, Hijikata M
  • Organizer: 第63回日本ウイルス学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2015-11-23
• [Presentation] Transfer hepatitis C virus from human liver cells to hepatic stellate cells (2015)
  • Author(s): Zaitsu T, Aoyagi H, Fujimoto A, Matsuda M, Watanabe N, Watashi K, Suzuki R, Fukuhara T, Matsuura Y, Sakamaki Y, Ichinose S, Wake K, Suzuki T, Iijima H, Matsuura T, Tamura K, Wakita T, Aizaki H
  • Organizer: 第63回日本ウイルス学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2015-11-23
• [Presentation] Identification of flavonoid derivative that directly acts on hepatitis B virus surface protein and inhibits viral entry (2015)
  • Author(s): Tsukuda S, Watashi K, Hamada Y, Isogawa M, Iwamoto M, Suzuki R, Aizaki H, Kojima S, Sugiyama M, Saito A, Tanaka Y, Mizokami M, Wakita T
  • Organizer: 第63回日本ウイルス学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2015-11-23
• [Presentation] Investigation of mechanisms of interaction between host glycosylation system and hepatitis B virus replication system (2015)
  • Author(s): Okutsu S, Ito K, Yoneda M, Angata K, Watashi K, Wakita T, Iijima S, Tanaka Y, Tong S, Mizokami M, Narimatsu H
  • Organizer: 第63回日本ウイルス学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2015-11-23
• [Presentation] Bivalent vaccine platform based on Japanese encephalitis virus (JEV) elicit neutralizing antibodies against JEV and hepatitis C virus (2015)
  • Author(s): Saga R, Fujimoto A, Watanabe N, Matsuda M, Hasegawa M, Watashi K, Aizaki H, Nakamura N, Konishi E, Kato T, Tajima S, Takasaki T, Takeyama H, Wakita T, Suzuki R
  • Organizer: 第63回日本ウイルス学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2015-11-23
• [Presentation] Identification of novel pyrimidotriazinone derivatives as inhibitors of HBV replication (2015)
  • Author(s): Toyama M, Hamasaki T, Okamoto M, Watashi K, Wakita T, Baba M
  • Organizer: 第63回日本ウイルス学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2015-11-23
• [Presentation] A new fungi-derived vanitaracin A specifically inhibits the entry of hepatitis B and D viruses through interacting with NTCP (2015)
  • Author(s): Kaneko M, Watashi K, Kamisuki S, Matsunaga H, Iwamoto M, Kawai F, Ohashi H, Tsukuda S, Shimura S, Suzuki R, Aizaki H, Sugiyama M, Park Sy, Ohtani N, Sugawara F, Tanaka Y, Mizokami M, Wakita T
  • Organizer: 第63回日本ウイルス学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2015-11-23
• [Presentation] Multimerization of hepatitis B virus core protein regulated by microtubules (2015)
  • Author(s): Iwamoto M, Watashi K, Sugiyama M, Suzuki R, Aizaki H, Tanaka Y, Mizokami M, Ohtani N, Koiwai O, Wakita T
  • Organizer: 第63回日本ウイルス学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2015-11-23
• [Presentation] Surfeit 4 is involved in HCV replication by interacting with NS4B (2015)
  • Author(s): Kong L, Aoyagi H, Matsuda M, Fujimoto A, Watashi K, Suzuki R, Yamagoe S, Dohmae N, Suzuki T, Sakamaki Y, Ichinose S, Suzuki T, Wakita T, Aizaki H
  • Organizer: 第63回日本ウイルス学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2015-11-23
• [Presentation] Hepatitis B virus downregulates expression of CIDE-B and CIDE-C and impairs lipid droplet growth (2015)
  • Author(s): Yasumoto J, Kasai H, Tanaka T, Watashi K, Wakita T, Yamashita A, Dobashi-Okuyama K, Moriishi K
  • Organizer: 第63回日本ウイルス学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2015-11-23
• [Presentation] SKIV2L-mediated RNA-exosome regulation of HBV replication (2015)
  • Author(s): Aly HH, Watashi K, Chayama K, Kato T, Wakita T
  • Organizer: 第63回日本ウイルス学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2015-11-23
• [Presentation] Egression of hepatitis B virus particles is promoted by long chain saturated fatty acid (2015)
  • Author(s): Okamura H, Akahori Y, Kim S, Nio Y, Watashi K, Wakita T, Hijikata M
  • Organizer: 第63回日本ウイルス学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2015-11-23
• [Presentation] Flutamide-mediated disruption of lipid droplets impairs the host permisiveness to hepatitis C virus production (2015)
  • Author(s): Ohashi H, Watashi K, Nakajima S, Kim S, Suzuki R, Aizaki H, Fukasawa M, Kamisuki S, Sugawara F, Ohtani N, Wakita T
  • Organizer: 第63回日本ウイルス学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2015-11-23
• [Presentation] Human iPS-derived hepatocytes as an in vitro HBV infection model (2015)
  • Author(s): Sakurai F, Yamamoto T, Mitani S, Takayama K, Tachibana M, Watashi K, Wakita T, Iijima S, Tanaka Y, Mizuguchi H
  • Organizer: 第63回日本ウイルス学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2015-11-23
• [Presentation] Metachromin A, sesquiterpene from marine sponge Dactylospongia metachromia, exerts anti-HBV activity via inhibition of HBV core promoter (2015)
  • Author(s): Yamashita A, Tanaka T, Okuyama-Dobashi K, Kasai H, Watashi K, Wakita T, Toyama M, Baba M, Moriishi K
  • Organizer: 第63回日本ウイルス学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2015-11-23
• [Presentation] Chemical genetics for virus research: Interface of drug development and basic virology (2015)
  • Author(s): Watashi K
  • Organizer: The 63rd Annual Meeting of the Japanese Society for Virology
  • Place of Presentation: 福岡
  • Year and Date: 2015-11-22
  • Invited
• [Presentation] Japanese encephalitis virus (JEV)-subviral particles harboring HCV neutralization epitopes elicit neutralizing antibodies against JEV and HCV (2015)
  • Author(s): Saga R, Fujimoto A, Watanabe N, Matsuda M, Hasegawa M, Watashi K, Aizaki H, Nakamura N, Konishi E, Kato T, Takeyama H, Wakita T, Suzuki R
  • Organizer: 22nd International Symposium on Hepatitis C Virus and Related Viruses
  • Place of Presentation: Strasbourg (France)
  • Year and Date: 2015-10-11
  • Int'l Joint Research
• [Presentation] Quantifying activity optimizes drug combinations against hepatitis C virus infection (2015)
  • Author(s): Iwami S, Tanaka Y, Wakita T, Watashi K
  • Organizer: 22nd International Symposium on Hepatitis C Virus and Related Viruses
  • Place of Presentation: Strasbourg (France)
  • Year and Date: 2015-10-11
  • Int'l Joint Research
• [Presentation] Development of a cell culture and infection system for hepatitis B virus using 3D cultured immortalized human hepatocytes (2015)
  • Author(s): Akahori Y, Kato H, Fujita T, Moriishi K, Watashi K, Wakita T, Hijikata M
  • Organizer: 2015 International Meeting of Molecular Biology of Hepatitis B Viruses
  • Place of Presentation: Bad Nauheim(Germany)
  • Year and Date: 2015-10-07
  • Int'l Joint Research
• [Presentation] Cilnidipine inhibits the early phase of HBV infection in a NTCP-independent mechanism (2015)
  • Author(s): Tsukuda S, Watashi K, Iwamoto M, Suzuki R, Aizaki H, Kojima S, Tanaka Y, Wakita T
  • Organizer: 2015 International Meeting of Molecular Biology of Hepatitis B Viruses
  • Place of Presentation: Bad Nauheim(Germany)
  • Year and Date: 2015-10-07
  • Int'l Joint Research
• [Presentation] Identification of HBV entry inhibitors, based on the cyclosporin structure (2015)
  • Author(s): Shimura S, Watashi K, Sluder A, Peel M, Kawai F, Sugiyama M, Park SY, Tanaka Y, Mizokami M, Wakita T
  • Organizer: 2015 International Meeting of Molecular Biology of Hepatitis B Viruses
  • Place of Presentation: Bad Nauheim(Germany)
  • Year and Date: 2015-10-07
  • Int'l Joint Research
• [Presentation] Dual function of RIG-I as innate antiviral mediator against hepatitis B virus (2015)
  • Author(s): Sato S, Li K, Kameyama T, Hayashi T, Ishida Y, Murakami S, Watanabe T, Iijima S, Sakurai Y, Watashi K, Tsutsumi S, Sato Y, Akita H, Wakita T, Rice Cm, Harashima H, Kohara M, Tanaka Y, Takaoka A
  • Organizer: 2015 International Meeting of Molecular Biology of Hepatitis B Viruses
  • Place of Presentation: Bad Nauheim(Germany)
  • Year and Date: 2015-10-07
  • Int'l Joint Research
• [Presentation] Anti-HBV talens delivered by recombinant adeno-associated viral vectors (rAAV) efficiently inhibit HBV replication in vivo and in vitro (2015)
  • Author(s): Nicholson S, Moyo B, Bloom K, Mussolino C, Cathomen T, Watashi K, Ely A, Arbuthnot P
  • Organizer: 2015 International Meeting of Molecular Biology of Hepatitis B Viruses
  • Place of Presentation: Bad Nauheim(Germany)
  • Year and Date: 2015-10-07
  • Int'l Joint Research
• [Presentation] Development of anti-HBs monoclonal antibody targeting HBs-NTCP interaction (2015)
  • Author(s): Matsunaga S, Miyakawa K, Watashi K, Sugiyama M, Mizokami M, Wakita T, Ryo A
  • Organizer: 2015 International Meeting of Molecular Biology of Hepatitis B Viruses
  • Place of Presentation: Bad Nauheim(Germany)
  • Year and Date: 2015-10-07
  • Int'l Joint Research
• [Presentation] Pyrimidotriazinone derivatives as novel inhibitors of hepatitis B virus core assembly (2015)
  • Author(s): Toyama M, Hamasaki T, Okamoto M, Watashi K, Wakita T, Baba M
  • Organizer: 2015 International Meeting of Molecular Biology of Hepatitis B Viruses
  • Place of Presentation: Bad Nauheim(Germany)
  • Year and Date: 2015-10-07
  • Int'l Joint Research
• [Presentation] Identification of a new tricyclic polyketide, vanitaracin A, which inhibits the entry of HBV, HDV, and nucleoside analog-resistant HBV though targeting NTCP (2015)
  • Author(s): Kaneko M, Watashi K, Kamisuki S, Matsunaga H, Iwamoto M, Kawai F, Ohashi H, Tsukuda S, Shimura S, Suzuki R, Aizaki H, Sugiyama M, Park SY, Ohtani N, Sugawara F, Tanaka Y, Mizokami M, Sureau C, Wakita T
  • Organizer: 2015 International Meeting of Molecular Biology of Hepatitis B Viruses
  • Place of Presentation: Bad Nauheim(Germany)
  • Year and Date: 2015-10-07
  • Int'l Joint Research
• [Presentation] Inhibition of hepatitis B virus infection by docosahexaenoic acid in cultured cells (2015)
  • Author(s): Fukasawa M, Shimizu Y, Shirasago Y, Watashi K, Tanaka Y, Wakita T, Kondoh M, Yagi K, Hanada K
  • Organizer: 2015 International Meeting of Molecular Biology of Hepatitis B Viruses
  • Place of Presentation: Bad Nauheim(Germany)
  • Year and Date: 2015-10-07
  • Int'l Joint Research
• [Presentation] Identification of NTCP-targeting small molecules that inhibit HBV entry by cell-based and in vitro technologies (2015)
  • Author(s): Watashi K, Tsukuda S, Shimura S, Kaneko M, Sluder A, Peel M, Kamisuki S, Matsunaga S, Morishita R, Futamura Y, Kondoh Y, Suzuki R, Aizaki H, Sugiyama M, Borroto-Esoda K, Ryo A, Sugawara F, Osada H, Tanaka Y, Mizokami M, Wakita T
  • Organizer: 2015 International Meeting of Molecular Biology of Hepatitis B Viruses
  • Place of Presentation: Bad Nauheim(Germany)
  • Year and Date: 2015-10-07
  • Int'l Joint Research
• [Presentation] Molecular dissection of HBV evasion from restriction factor tetherin (2015)
  • Author(s): Miyakawa K, Matsunaga S, Watashi K, Sugiyama M, Mizokami M, Wakita T, Ryo A
  • Organizer: 2015 International Meeting of Molecular Biology of Hepatitis B Viruses
  • Place of Presentation: Bad Nauheim(Germany)
  • Year and Date: 2015-10-07
  • Int'l Joint Research
• [Presentation] Investigation of the mechanism of interaction between host glycosylation system and hepatitis B virus replication system (2015)
  • Author(s): Ito K, Yoneda M, Angata K, Watashi K, Wakita T, Iijima S, Tanaka Y, Tong S, Kuno A, Sugiyama M, Mizokami M, Narimatsu H
  • Organizer: 2015 International Meeting of Molecular Biology of Hepatitis B Viruses
  • Place of Presentation: Bad Nauheim(Germany)
  • Year and Date: 2015-10-07
  • Int'l Joint Research
• [Presentation] SKIV2L-dependent HBV-RNA degradation by the RNA-exosome, a new anti-HBV host mechanism (2015)
  • Author(s): Aly HH, Watashi K, Chayama K, Kato T, Wakita T
  • Organizer: 2015 International Meeting of Molecular Biology of Hepatitis B Viruses
  • Place of Presentation: Bad Nauheim(Germany)
  • Year and Date: 2015-10-07
  • Int'l Joint Research
• [Presentation] Long chain saturated fatty acid contributes to efficient egression of hepatitis B virus particles (2015)
  • Author(s): Okamura H, Akahori Y, Kim S, Nio Y, Watashi K, Wakita T, Hijikata M
  • Organizer: 2015 International Meeting of Molecular Biology of Hepatitis B Viruses
  • Place of Presentation: Bad Nauheim(Germany)
  • Year and Date: 2015-10-07
  • Int'l Joint Research
• [Presentation] AAV-delivered engineered repressor transcription activator-like effectors (rTALEs) inactivate hepatitis B virus replication in hNTCP cells and in mice (2015)
  • Author(s): Moyo B, Nicholson S, Roelofse I, Bloom K, Mussolino C, Cathomen T, Watashi K, Ely A, Arbuthnot P
  • Organizer: 2015 International Meeting of Molecular Biology of Hepatitis B Viruses
  • Place of Presentation: Bad Nauheim(Germany)
  • Year and Date: 2015-10-07
  • Int'l Joint Research
• [Presentation] C型肝炎治療薬の個性を探る ～多剤併用から費用対効果の考察まで～ (2015)
  • Author(s): 渡士幸一
  • Organizer: ウイルス感染現象における宿主細胞コンピテンシーの分子基盤 第2回若手研究会
  • Place of Presentation: 三浦
  • Year and Date: 2015-07-18
• [Presentation] 創薬を指向した肝炎ウイルス感染増殖機構の解析 (2015)
  • Author(s): 渡士幸一
  • Organizer: 京都大学ウイルス研究所 ウイルス研究の潮流
  • Place of Presentation: 京都
  • Year and Date: 2015-07-15
  • Invited
• [Presentation] NTCPを標的としたB型肝炎ウイルス感染阻害戦略 (2015)
  • Author(s): 渡士幸一
  • Organizer: 第31回日本DDS学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2015-07-02
  • Invited
• [Presentation] ウイルス感染増殖系を基盤とした天然化合物の新規生理機能の解析 (2015)
  • Author(s): 渡士幸一
  • Organizer: 天然物ケミカルバイオロジー 分子標的と活性制御 第7回公開シンポジウム
  • Place of Presentation: 仙台
  • Year and Date: 2015-06-08
• [Presentation] 新規真菌二次代謝産物 SF177 の B 型肝炎ウイルス感染阻害活性および NTCP トランスポーター阻害活性の同定 (2015)
  • Author(s): 金子学, 渡士幸一, 松永大輝, 紙透伸治, 岩本将士, 河合文啓, 鈴木亮介, 相崎英樹, 朴三用, 菅原二三男, 脇田隆字
  • Organizer: 第25回抗ウイルス療法学会総会
  • Place of Presentation: 東京
  • Year and Date: 2015-05-23
• [Presentation] B型肝炎ウイルスに対する直接標的薬proanthocyanidinおよび宿主標的薬vanitaracinの同定および感染阻害機構の解析 (2015)
  • Author(s): 渡士幸一, 九十田千子, 金子学, 松永大輝, 紙透伸治, 齊藤安貴子, 鈴木亮介, 相崎英樹, 杉山真也, 溝上雅史, 菅原二三男, 田中靖人, 脇田隆字
  • Organizer: 第25回抗ウイルス療法学会総会
  • Place of Presentation: 東京
  • Year and Date: 2015-05-23
• [Presentation] Neoechinulin Bのliver X receptor転写阻害効果の同定およびそれによるC型肝炎ウイルス複製制御機構の解析 (2015)
  • Author(s): 渡士幸一, 中嶋翔, 紙透伸治, Izaguirre-Carbonell J, Kwon Atj, 鈴木治和, 九十田千子, 岡田麻衣子, 鈴木亮介, 相崎英樹, 菅原二三男, 脇田隆字
  • Organizer: 第25回抗ウイルス療法学会総会
  • Place of Presentation: 東京
  • Year and Date: 2015-05-23
• [Presentation] カイメン由来化合物metachromin A及びその類縁化合物の抗HBV活性の検討 (2015)
  • Author(s): 山下篤哉, 田中智久, 葛西宏威, 渡士幸一, 脇田隆字, 外山政明, 馬場昌範, 前川伸哉, 榎本信幸, 玉城麻友美, 田中淳一, 森石恆司
  • Organizer: 第25回抗ウイルス療法学会総会
  • Place of Presentation: 東京
  • Year and Date: 2015-05-23
• [Presentation] 新規核酸誘導体7-deazaneplanocin A誘導体の抗HBV効果について (2015)
  • Author(s): 外山政明, 濱崎隆之, 岡本実佳, 渡士幸一, 脇田隆字, Ashoke Sharon, 馬場昌範
  • Organizer: 第25回抗ウイルス療法学会総会
  • Place of Presentation: 東京
  • Year and Date: 2015-05-23
• [Presentation] B型肝炎ウイルスの感染に対するRIG-Iを介した自然免疫応答機構 (2015)
  • Author(s): 佐藤精一, 李凱, 亀山武志, 林隆也, 石田雄二, 村上周子, 渡邊綱正, 飯島沙幸, 櫻井遊, 渡士幸一, 堤進, 佐藤悠介, 秋田英万, 脇田隆字, Rice Cm, 原島秀吉, 小原道法, 田中靖人, 高岡晃教
  • Organizer: 第25回抗ウイルス療法学会総会
  • Place of Presentation: 東京
  • Year and Date: 2015-05-23
• [Presentation] ヒト肝癌細胞 FLC4 における B 型肝炎ウイルスレセプター NTCP の発現と誘導に関する検討 (2015)
  • Author(s): 松浦知和, 松本喜弘, 永森収志, 渡士幸一, 金井好克, 小嶋聡一, 脇田隆字, 相崎英樹
  • Organizer: 第51回日本肝臓学会総会
  • Place of Presentation: 熊本
  • Year and Date: 2015-05-22
• [Presentation] NTCP as a drug target of anti-hepatitis B virus infection (2015)
  • Author(s): Watashi K
  • Organizer: 2015 American Association of Pharmaceutical Scientists (AAPS)/ International Transporter Consortium (ITC) Workshop on Drug Transporter in ADME: From the Bench to the Bedside
  • Place of Presentation: Baltimore (USA)
  • Year and Date: 2015-04-21
  • Int'l Joint Research / Invited
• [Presentation] B型肝炎ウイルス(HBV) large Sタンパク質とNTCPの相互作用阻害による抗HBV戦略 (2014)
  • Author(s): 渡士幸一、Ann Sluder、松永智子、梁明秀、森下了、岩本将士、九十田千子、鈴木亮介、相崎英樹、Katyna Borroto-Esoda、田中靖人、楠原洋之、杉山真也、溝上雅史、脇田隆字
  • Organizer: 第62回日本ウイルス学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2014-11-12
• [Presentation] ラパトアセッション - +鎖RNAウイルス - (2014)
  • Author(s): 渡士幸一
  • Organizer: 第62回日本ウイルス学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2014-11-12
  • Invited
• [Presentation] レチノイド阻害剤はNTCP発現修飾を介して宿主細胞のB型肝炎ウイルス感染感受性を消失させる (2014)
  • Author(s): 九十田千子、渡士幸一、岩本将士、鈴木亮介、相崎英樹、小嶋聡一、杉山真也、田中靖人、溝上雅史、脇田隆字
  • Organizer: 第62回日本ウイルス学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2014-11-12
• [Presentation] 効率的な B 型肝炎ウイルス(HBV)複製評価系を用いた微小管依存的な HBV 複製機構の解析 (2014)
  • Author(s): 岩本将士、渡士幸一、杉山真也、鈴木亮介、相崎英樹、田中靖人、溝上雅史、大谷直子、小祝修、脇田隆字
  • Organizer: 第62回日本ウイルス学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2014-11-12
• [Presentation] The identification of a new interferon-independent host mechanism suppressing hepatitis B virus replication (2014)
  • Author(s): Hussein Aly、渡士幸一、茶山一彰、脇田隆字
  • Organizer: 第62回日本ウイルス学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2014-11-12
• [Presentation] 日本脳炎ウイルスおよびC 型肝炎ウイルス2価ワクチン抗原の発現と中和抗体の誘導 (2014)
  • Author(s): 嵯峨涼平、藤本陽、渡邉則幸、松田麻未、長谷川慎、渡士幸一、相崎英樹、中村紀子、小西英二、加藤孝宣、田島茂、高崎智彦、竹山春子、脇田隆字、鈴木亮介
  • Organizer: 第62回日本ウイルス学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2014-11-12
• [Presentation] 遺伝子組換え酵母由来B型肝炎ウイルス様粒子の細胞表面への結合に関与する宿主因子の解析 (2014)
  • Author(s): 松田麻未、鈴木亮介、嵯峨涼平、藤本陽、渡士幸一、相崎英樹、森石恆司、岡本徹、松浦善治、黒田俊一、脇田隆字
  • Organizer: 第62回日本ウイルス学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2014-11-12
• [Presentation] 宿主防御因子 Tetherin-BST2 によるB型肝炎ウイルス感染抑制とその回避機構の解明 (2014)
  • Author(s): 宮川敬、松永智子、渡士幸一、杉山真也、溝上雅史、脇田隆字、梁明秀
  • Organizer: 第62回日本ウイルス学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2014-11-12
• [Presentation] 天然有機化合物 Neoechinulin B を利用した liver X receptor による C 型肝炎ウイルス産生制御機構の解析 (2014)
  • Author(s): 中嶋翔、渡士幸一、紙透伸治、竹本健二、Jesus Izaguirre-Carbonell、鈴木亮介、 相崎英樹、菅原二三男、脇田隆字
  • Organizer: 第62回日本ウイルス学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2014-11-11
• [Presentation] Aryl hydrocarbon receptor による脂肪滴形成及び C 型肝炎ウイルス粒子構築の制御 (2014)
  • Author(s): 大橋啓史、渡士幸一、中嶋翔、金ソルイ、鈴木亮介、相崎英樹、紙透伸治、菅原二三男、脇田隆字
  • Organizer: 第62回日本ウイルス学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2014-11-11
• [Presentation] Prolactin regulatory element binding protein is involved in hepatitis C virus replication by interacting with NS4B (2014)
  • Author(s): Lingbao Kong、青柳春代、松田麻未、藤本陽、渡士幸一、鈴木亮介、山越智、堂前直、鈴木健裕、鈴木哲朗、脇田隆字、相崎英樹
  • Organizer: 第62回日本ウイルス学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2014-11-11
• [Presentation] トリプシン・EDTA による NTCP 依存 HBV 感染の増強 (2014)
  • Author(s): 土橋香織、葛西宏威、田中智久、陳文家、渡士幸一、脇田隆字、山下篤哉、梁明秀、岡本徹、松浦善治、森石恆司
  • Organizer: 第62回日本ウイルス学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2014-11-11
• [Presentation] ヒトiPS細胞由来分化誘導肝細胞を用いたB型肝炎ウイルス感染評価系の開発 (2014)
  • Author(s): 山本達郎、櫻井文教、高山和雄、立花雅史、渡士幸一、脇田隆字、飯島沙幸、田中靖人、水口裕之
  • Organizer: 第62回日本ウイルス学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2014-11-11
• [Presentation] ヒトNTCP恒常発現不死化ヒト肝細胞を用いたB型肝炎ウイルス培養細胞感染系の構築 (2014)
  • Author(s): 赤堀祐一、加藤博己、藤田尚志、渡士幸一、脇田隆字、土方誠
  • Organizer: 第62回日本ウイルス学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2014-11-11
• [Presentation] 効率的なHBV感染培養細胞系の構築に関する研究 (2014)
  • Author(s): 深澤征義、清水芳実、白砂圭崇、岩本将士、渡士幸一、田中靖人、脇田隆字、近藤昌夫、八木清仁、花田賢太郎
  • Organizer: 第62回日本ウイルス学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2014-11-11
• [Presentation] HBV感染による細胞内脂肪滴形成への影響 (2014)
  • Author(s): 安本順、葛西宏威、土橋香織、山下篤哉、渡士幸一、脇田隆字、田中智久、森石恆司
  • Organizer: 第62回日本ウイルス学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2014-11-11
• [Presentation] 海洋生物抽出物ライブラリーソースからのB型肝炎ウイルス転写活性抑制化合物の探索 (2014)
  • Author(s): 山下篤哉、藤本雄介、田中智久、葛西宏威、児玉栄一、渡士幸一、脇田隆字、前川伸哉、榎本信幸、田中淳一、森石恆司
  • Organizer: 第62回日本ウイルス学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2014-11-11
• [Presentation] 新規 7-deazaneplanocin A 及び 7-deaza-8-azaneplanocin A 誘導体の抗 HBV 効果 (2014)
  • Author(s): 外山政明、濱崎隆之、岡本実佳、渡士幸一、脇田隆字、馬場昌範
  • Organizer: 第62回日本ウイルス学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2014-11-11
• [Presentation] Identification of neoechinulin B that represses liver X receptor-mediated transcription and inhibits hepatitis C virus replication (2014)
  • Author(s): Nakajima S, Watashi K
  • Organizer: The 3rd International Symposium on Chemical Biology of Natural Products: Target ID and Regulation of Bioactivity
  • Place of Presentation: Osaka (Japan)
  • Year and Date: 2014-10-28
• [Presentation] 宿主細胞における肝炎ウイルス感染増殖機構とこれを標的とした創薬 (2014)
  • Author(s): 渡士幸一
  • Organizer: 第87回日本生化学会大会
  • Place of Presentation: 京都
  • Year and Date: 2014-10-16
  • Invited
• [Presentation] 低分子化合物を通して理解する肝炎ウイルス生活環 (2014)
  • Author(s): 渡士幸一
  • Organizer: ウイルス学キャンプ in 湯河原
  • Place of Presentation: 湯河原
  • Year and Date: 2014-09-17
  • Invited
• [Presentation] Ruglation of hepatitis C virus replication by liver X receptor is disrupted by a fungi-derived neoechinulin B (2014)
  • Author(s): Nakajima S, Watashi K, Kamisuki S, Takemoto K, Izaguirre-Carbonell J, Suzuki R, Aizaki H, Sugawara F, Wakita T
  • Organizer: 21th International Symposium on Hepatitis C Virus and Related Viruses
  • Place of Presentation: Banff (Canada)
  • Year and Date: 2014-09-09
• [Presentation] Flutamide inhibits hepatitis C virus assembly through disrupting lipid droplets (2014)
  • Author(s): Ohashi H, Watashi K, Nakajima S, Kim S, Suzuki R, Aizaki H, Kamisuki S, Sugawara F, Wakita T
  • Organizer: 21th International Symposium on Hepatitis C Virus and Related Viruses
  • Place of Presentation: Banff (Canada)
  • Year and Date: 2014-09-09
• [Presentation] Japanese Encephalitis Virus-subviral particles harboring HCV neutralization epitopes induce neutralizing antibodies against HCV (2014)
  • Author(s): Saga R, Fujimoto A, Watanabe N, Matsuda M, Hasegawa M, Watashi K, Aizaki H, Nakamura N, Konishi E, Kato T, Takeyama H, Wakita T, Suzuki R
  • Organizer: 21th International Symposium on Hepatitis C Virus and Related Viruses
  • Place of Presentation: Banff (Canada)
  • Year and Date: 2014-09-09
• [Presentation] Single domain intrabodies against HCV core inhibit viral propagation and core-induced NF-kB activation (2014)
  • Author(s): Suzuki R, Saito K, Matsuda M, Sato M, Kanegae Y, Watashi K, Aizaki H, Chiba J, Saito I, Wakita T, Suzuki T
  • Organizer: 21th International Symposium on Hepatitis C Virus and Related Viruses
  • Place of Presentation: Banff (Canada)
  • Year and Date: 2014-09-09
• [Presentation] Maintenance of HCV infectivity by down-regulating hepatic lipase expression (2014)
  • Author(s): Fujimoto A, Aizaki H, Matsuda M, Watanabe N, Watashi K, Suzuki R, Suzuki T, Wakita T
  • Organizer: 21th International Symposium on Hepatitis C Virus and Related Viruses
  • Place of Presentation: Banff (Canada)
  • Year and Date: 2014-09-09
• [Presentation] NS5A-associated membrane protein, embryonic lethal, abnormal vision, drosophila-like 1, regulates hepatitis C virus RNA synthesis and translation (2014)
  • Author(s): Goto K, Fujimoto A, Watashi K, Suzuki R, Yamagoe S, Moriya K, Yotsuyanagi H, Koike K, Suzuki T, Miyamura T, Wakita T, Aizaki H
  • Organizer: 21th International Symposium on Hepatitis C Virus and Related Viruses
  • Place of Presentation: Banff (Canada)
  • Year and Date: 2014-09-09
• [Presentation] Microtubule-dependent hepatitis B virus (HBV) replication revealed by chemical screening on an efficient HBV-replicating cell line (2014)
  • Author(s): Iwamoto M, Watashi K, Sugiyama M, Suzuki R, Aizaki H, Tanaka Y, Mizokami M, Ohtani N, Koiwai O, Wakita T
  • Organizer: 2014 International Meeting on the Molecular Biology of Hepatitis B Viruses
  • Place of Presentation: Los Angeles (USA)
  • Year and Date: 2014-09-04
• [Presentation] Retinoid inhibitors abolish the host permissiveness to HBV infection by modulating NTCP expression (2014)
  • Author(s): Tsukuda S, Watashi K, Iwamoto M, Suzuki R, Aizaki H, Kojima S, Sugiyama M, Tanaka Y, Mizokami M, Wakita T
  • Organizer: 2014 International Meeting on the Molecular Biology of Hepatitis B Viruses
  • Place of Presentation: Los Angeles (USA)
  • Year and Date: 2014-09-04
• [Presentation] Wheat germ cell-free system-based production of hepatitis B virus X (HBx) protein for generation and characterization of monoclonal antibody (2014)
  • Author(s): Matsunaga S, Miyakawa K, Watashi K, Wakita T, Ryo A
  • Organizer: 2014 International Meeting on the Molecular Biology of Hepatitis B Viruses
  • Place of Presentation: Los Angeles (USA)
  • Year and Date: 2014-09-04
• [Presentation] Efficient HBV infection system in cell cultured cells (2014)
  • Author(s): Fukasawa M, Shimizu Y, Shirasago Y, Iwamoto M, Watashi K, Tanaka Y, Wakita T, Kondoh M, Yagi K, Hanada K
  • Organizer: 2014 International Meeting on the Molecular Biology of Hepatitis B Viruses
  • Place of Presentation: Los Angeles (USA)
  • Year and Date: 2014-09-04
• [Presentation] Development of hepatitis B virus cell culture system using immortalized human hepatocytes pruducing exogenous Na+/taurocholate cotransporting polypeptide (2014)
  • Author(s): Akahori Y, Kato H, Fujita T, Watashi K, Wakita T, Hijikata M
  • Organizer: 2014 International Meeting on the Molecular Biology of Hepatitis B Viruses
  • Place of Presentation: Los Angeles (USA)
  • Year and Date: 2014-09-04
• [Presentation] Characterization of a culture system reproducing the NTCP-mediated HBV entry and its application to drug development (2014)
  • Author(s): Watashi K, Iwamoto M, Sluder A, Matsunaga S, Ryo A, Morishita R, Kwon ATJ, Suzuki H, Tsukuda S, Suzuki R, Aizaki H, Borroto-Esoda K, Sugiyama M, Tanaka Y, Mizokami M, Wakita T
  • Organizer: 2014 International Meeting on the Molecular Biology of Hepatitis B Viruses
  • Place of Presentation: Los Angeles (USA)
  • Year and Date: 2014-09-03
• [Presentation] 肝炎ウイルス生活環を標的とした抗ウイルス剤探索と分子基盤解明 (2014)
  • Author(s): 渡士幸一
  • Organizer: 平成26年度 遺伝子病制御研究所研究集会 感染・免疫・炎症・発癌
  • Place of Presentation: 札幌
  • Year and Date: 2014-07-03
  • Invited
• [Presentation] ヒトNTCP安定発現によるB型肝炎ウイルス(HBV)感染許容性の獲得とそれを用いたHBV侵入機構の解析 (2014)
  • Author(s): 岩本将士、渡士幸一、九十田千子、Hussein Aly、藤本陽、鈴木亮介、相崎英樹、脇田隆字、深澤征義、小祝修、楠原洋之
  • Organizer: 第22回肝病態生理研究会
  • Place of Presentation: 東京
  • Year and Date: 2014-05-30 – 2014-05-31
• [Presentation] 培養系を用いた抗B型肝炎ウイルス化合物の同定と作用機序解析 (2014)
  • Author(s): 渡士幸一、相崎英樹、脇田隆字
  • Organizer: 第50回日本肝臓学会総会
  • Place of Presentation: 東京
  • Year and Date: 2014-05-29
• [Presentation] C型肝炎ウイルス生活環全体を標的とした新規作用を有する抗ウイルス剤の探索 (2014)
  • Author(s): 脇田隆字、相崎英樹、渡士幸一
  • Organizer: 第50回日本肝臓学会総会
  • Place of Presentation: 東京
  • Year and Date: 2014-05-29
• [Presentation] グリチルリチンによる抗C型肝炎ウイルス作用 - phospholipase A2およびAutophagyによるHCV分泌過程の制御 - (2014)
  • Author(s): 青柳東代、相崎英樹、松本喜弘、鈴木亮介、渡士幸一、市野瀬志津子、松浦知和、鈴木哲朗、和氣健二郎、脇田隆字
  • Organizer: 第50回日本肝臓学会総会
  • Place of Presentation: 東京
  • Year and Date: 2014-05-29
• [Presentation] ウイルス感染培養系を基盤とした天然化合物の生理活性同定 (2014)
  • Author(s): 中嶋翔、渡士幸一
  • Organizer: 天然物ケミカルバイオロジー 分子標的と活性制御 第6回公開シンポジウム
  • Place of Presentation: 名古屋
  • Year and Date: 2014-05-28
• [Presentation] HBV感染受容体NTCPの発現調節機構の解析およびこれを阻害する低分子化合物の抗HBV効果 (2014)
  • Author(s): 九十田千子、渡士幸一、岩本将士、鈴木亮介、相崎英樹、小嶋聡一、脇田隆字
  • Organizer: 第24回抗ウイルス療法研究会総会
  • Place of Presentation: 富士急
  • Year and Date: 2014-05-09
• [Presentation] B型肝炎ウイルス(HBV)Lタンパク質とNTCPの相互作用阻害による抗HBV戦略 (2014)
  • Author(s): 渡士幸一、Ann Sluder、松永智子、梁明秀、森下了、岩本将士、九十田千子、鈴木亮介、相崎英樹、Katyna Borroto-Esoda、田中靖人、楠原洋之、杉山真也、溝上雅史、脇田隆字
  • Organizer: 第24回抗ウイルス療法研究会総会
  • Place of Presentation: 富士急
  • Year and Date: 2014-05-08
• [Presentation] C型肝炎ウイルス粒子の構築を阻害するflutamideの作用機序の解析 (2014)
  • Author(s): 大橋啓史、渡士幸一、中嶋翔、金ソルイ、鈴木亮介、相崎英樹、紙透伸治、菅原二三男、脇田隆字
  • Organizer: 第24回抗ウイルス療法研究会総会
  • Place of Presentation: 富士急
  • Year and Date: 2014-05-08
• [Presentation] グリチルリチンによる抗HCV作用 - phospholipase A2およびAutophagyによるC型肝炎ウイルス(HCV)分泌過程に与える影響 - (2014)
  • Author(s): 青柳東代、相崎英樹、藤本陽、松本喜弘、松田麻未、Su Su Hmwe、渡邉則幸、渡士幸一、鈴木亮介、市野瀬志津子、松浦知和、鈴木哲朗、和氣健二郎、脇田隆字
  • Organizer: 第24回抗ウイルス療法研究会総会
  • Place of Presentation: 富士急
  • Year and Date: 2014-05-08
• [Presentation] HBVカプシドタンパク質を標的とした新規抗HBV薬の探索 (2014)
  • Author(s): 外山政明、濱崎隆之、岡本実佳、渡士幸一、脇田隆字、馬場昌範
  • Organizer: 第24回抗ウイルス療法研究会総会
  • Place of Presentation: 富士急
  • Year and Date: 2014-05-08
• [Presentation] Anti-HBV Approach by Interfering the Interaction between HBV large surface protein and NTCP (2014)
  • Author(s): Watashi K
  • Organizer: 2nd Japan-Taiwan Research Symposium on Hepatitis B virus
  • Place of Presentation: Taipei (Taiwan)
  • Year and Date: 2014-04-19
• [Book] Encyclopedia of Signaling Molecules, 2nd Edition (2017)
  • Author(s): Tsukuda S, Iwamoto M, Watashi K
  • Publisher: Springer Nature