Inhibition of HIV-1 by Gag peptides
| Project/Area Number |
26460566
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Virology
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| Research Institution | National Institute of Infectious Diseases |
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Principal Investigator |
Murakami Tsutomu 国立感染症研究所, エイズ研究センター, 室長 (50336385)
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| Co-Investigator(Kenkyū-buntansha) |
玉村 啓和 東京医科歯科大学, 生体材料工学研究所, 教授 (80217182)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | HIV-1 / ペプチド / Gag蛋白質 / 抗HIV-1薬 / HIV / カプシド / 抗HIV-1活性 / マトリックス蛋白質 / カプシド蛋白質 |
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| Outline of Final Research Achievements |
We have constructed peptide libraries for matrix (MA) and capsid (CA) proteins of HIV-1 and investigated whether introduction of these peptides could inhibit HIV-1 replication in cell culture. We found that 9th fragment of the MA proteins, several fragments of the CA proteins including 15th fragment which contains the linker region of N- and C-terminal domains of CA and 19th fragment which contains the dimmer interface of C-terminal domain of CA have modest anti-HIV-1 activities in vitro, suggesting that these peptides could be lead compounds for further modifications.
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Report
(4 results)
Research Products
(9 results)
