Signaling mechanisms of chronic inflammation and metabolic diseases

• Project/Area Number: 26460571
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Immunology
• Research Institution: Mie University
• Principal Investigator: OGATA Masato 三重大学, 医学系研究科, 教授 (60224094)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 慢性炎症 / MAPキナーゼ / マクロファージ / 代謝症候群 / p38 / 遺伝子改変マウス

Outline of Final Research Achievements

Chronic inflammation and glucose tolerance in high fat diet-induced obesity and NASH model mice were ameliorated in mutant mice in which p38alpha gene was disrupted in hematopoietic cells. As a possible mechanism, involvement of p38alpha in the chemotaxis of proinflammatory M1 macropahges to their target organs was suggested. The p38alpha signaling cascade might be a common therapeutic target of diseases related to chronic inflammation induced by obesity and fatty liver.

Research Products

• [Journal Article] Anatomy of Mammalian Replication Domains. (2017)
  • Author(s): Takebayashi, S., Ogata, M., and Okumura, K.
  • Journal Title: Genes (Basel) Volume: 8 Issue: 4 Pages: 110-110
  • DOI: 10.3390/genes8040110
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Direct visualization of replication dynamics in early zebrafish embryos (2016)
  • Author(s): Kuriya, K., Higashiyama, E., Avsar-Ban, E., Okochi, N., Hattori, K., Ogata, S., Takebayashi, S.I., Ogata, M., Tamaru, Y., Okumura, K
  • Journal Title: Bioscience, biotechnology, and biochemistry Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Direct Visualization of DNA Replication Dynamics in Zebrafish Cells. Zebrafish (2015)
  • Author(s): Kuriya, K., Higashiyama, E., Avsar-Ban, E., Tamaru, Y., Ogata, S., Takebayashi, S., Ogata, M., Okumura, K.
  • Journal Title: Zebrafish Volume: 12 Issue: 5 Pages: 432-439
  • DOI: 10.1080/09168451.2016.1141039
  • Peer Reviewed / Open Access
• [Presentation] Engagement of TCR with foreign and self antigens trigger distinct signaling pathways to generate different T cell responses (2016)
  • Author(s): Moe Shiokawa, Eri Ishikawa, Masato Ogata, Takashi Saito, Sho Yamasaki
  • Organizer: 17th International Congress of Immunology
  • Place of Presentation: Melbourne, Austraria
  • Year and Date: 2016-08-21
  • Int'l Joint Research
• [Presentation] p38 alpha in pro-inflammatory macrophages regulates progression of nonalcoholic steatohepatitis (NASH) (2015)
  • Author(s): Sadatsugu Ookuma, Shinichiro Takebayashi, Masato Ogata
  • Organizer: 第88回日本生化学学会大会
  • Place of Presentation: 神戸ポートアイランド（兵庫県・神戸市）
  • Year and Date: 2015-12-01
• [Presentation] The role of p38 alpha in pro-inflammatory macrophages in nonalcoholic steatohepatitis (NASH) (2015)
  • Author(s): Sadatsugu Ookuma, Masato Ogata
  • Organizer: 第44回日本免疫学会学術集会
  • Place of Presentation: 札幌コンベンションセンター（北海道・札幌市）
  • Year and Date: 2015-11-18
• [Presentation] Roles of p38alpha mitogen-activated protein kinase in macrophage in high-fat-induced chronic inflammation and insulin resistance.. (2014)
  • Author(s): Sadatsugu Ookuma, Masato Ogata
  • Organizer: 第43回日本免疫学会学術集会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2014-12-10 – 2014-12-12
• [Presentation] p38alpha in macrophages regulates high-fat-induced obesity and insulin resistance (2014)
  • Author(s): Sadatsugu Ookuma, Takahiko Fujikawa, Kinya Otsu, Masato Ogata
  • Organizer: 第87回日本生化学学会大会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2014-10-15 – 2014-10-18