| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
Recently, a dominant negative mutation of the Stat3 gene was identified as a major molecular cause of hyper-IgE syndrome (HIES).To elucidate a mechanism of high serum IgE levels in HIES, IgE antibody responses during non-immunization and immunization were evaluated in a mouse model of HIES, Stat3-DN mice. In Stat3-DN mice, increased serum IgE levels was observed starting from 5 weeks of age under non-immunized condition. When Stat3-DN mice were immunized with a T-cell dependent antigen, the production of antigen-specific IgE is enhanced compared to wild-type mice, suggesting spontaneous increase of serum IgE levels may be caused by chronic stimulation of environment.
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