| Project/Area Number |
26460583
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
Fujii Shin-ichiro 国立研究開発法人理化学研究所, 統合生命医科学研究センター, チームリーダー (10392094)
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| Co-Investigator(Kenkyū-buntansha) |
清水 佳奈子 国立研究開発法人理化学研究所, 統合生命医科学研究センター, 上級研究員 (20391980)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | NKT細胞 / 樹状細胞 / 記憶免疫 / 抗腫瘍免疫 |
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| Outline of Final Research Achievements |
Invariant (i)NKT cells recognize a complex of the antigen-presenting MHC-like molecule CD1d and a glycolipid and play a key role at the initial immunological defense in infection and cancer. After the activation, the fate of iNKT cells toward memory has not been identified. Here we show the presence of effector memory-like KLRG1+iNKT cells in the lung. They express the distinct expression of adhesion molecules, chemokine receptors and NK receptors and can produce high amount of IFN-gamma. In addition, we identified the specific molecules, of KLRG1+ iNKT cells by RNA-seq analysis.
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