Characterization of memory invariant NKT cells
| Project/Area Number |
26460583
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
Fujii Shin-ichiro 国立研究開発法人理化学研究所, 統合生命医科学研究センター, チームリーダー (10392094)
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| Co-Investigator(Kenkyū-buntansha) |
清水 佳奈子 国立研究開発法人理化学研究所, 統合生命医科学研究センター, 上級研究員 (20391980)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | NKT細胞 / 樹状細胞 / 記憶免疫 / 抗腫瘍免疫 |
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| Outline of Final Research Achievements |
Invariant (i)NKT cells recognize a complex of the antigen-presenting MHC-like molecule CD1d and a glycolipid and play a key role at the initial immunological defense in infection and cancer. After the activation, the fate of iNKT cells toward memory has not been identified. Here we show the presence of effector memory-like KLRG1+iNKT cells in the lung. They express the distinct expression of adhesion molecules, chemokine receptors and NK receptors and can produce high amount of IFN-gamma. In addition, we identified the specific molecules, of KLRG1+ iNKT cells by RNA-seq analysis.
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Report
(4 results)
Research Products
(32 results)
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[Journal Article] Myeloid cell-derived soluble IL-6 receptor diminishes the differentiation of tumor-specific Th1 cells to exacerbate tumor progression2017
Author(s)
Shinojima N, Hossain A, Takezaki T, Fueyo J, Gumin J, Gao F, Nwajei F, Marini FC, Andreeff M, Kuratsu J, Lang FF.
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Journal Title
Cancer Res.
Volume: 73(7)
Pages: 1311-1318
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Efficient regeneration of Human Vα24+ invariant NKT cells and their anti-tumor activity in vivo.2016
Author(s)
Yamada D, Iyoda T, Vizcardo R, Shimizu K, Sato Y, Endo TA, Kitahara G, Okoshi M, Kobayashi M, Sakurai M, Ohara O, Taniguchi M, Koseki H, Fujii S*.
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Journal Title
Stem Cells
Volume: 34
Pages: 2852-2860
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Systemic DC activation modulates the tumor microenvironment and shapes the long-lived tumor-specific memory mediated by CD8+ T cells2016
Author(s)
1.Shimizu K, Yamasaki S, Shinga J, Sato Y, Watanabe T, Ohara O, Kuzushima K, Yagita H, Komuro Y, Asakura M, and Fujii S.
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Journal Title
Cancer Res
Volume: in press
Related Report
Peer Reviewed / Acknowledgement Compliant
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