ZNF131, a novel partner molecule of the transcription factor GATA3
| Project/Area Number |
26460585
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | Tokyo Metropolitan Institute of Medical Science |
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Principal Investigator |
MIYATAKE Shoichiro 公益財団法人東京都医学総合研究所, ゲノム医科学研究分野, 研究員 (30239420)
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| Co-Investigator(Kenkyū-buntansha) |
青木 和久 公益財団法人東京都医学総合研究所, ゲノム医科学研究分野, 主任研究員 (00280785)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | ZNF131 / GATA3 / BTB Znフィンガー / T細胞 / B細胞 / p21 / 線維芽細胞 / 転写因子 / 細胞増殖 |
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| Outline of Final Research Achievements |
ZNF131 is one of the BTB Zn finger family proteins. GATA3 is a transcription factor critically involved in many aspects of T cell differentiation and function as well as the development of various tissues such as mammary gland, kidney, inner ear etc. We identified ZNF131 as one of GATA3 binding proteins. ZNF131 is required for the expansion of thymocytes accompanied with the differentiation of double positive population. ZNF131 is also required for the proliferation of T cells upon TCR stimulation. ZNF131 is critical for the proliferation and gene rearrangement that take place during the pro B cell stage of B cell development. ZNF131 suppresses the expression of cdk inhibitor p21 (cdkn1a), thus it counteracts against the effect of tumor suppressor p53.
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Report
(4 results)
Research Products
(8 results)
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[Journal Article] BTB-ZF Protein Znf131 Regulates Cell Growth of Developing and Mature T Cells.2015
Author(s)
Iguchi T, Aoki K, Ikawa T, Taoka M, Taya C, Yoshitani H, Toma-Hirano M, Koiwai O, Isobe T, Kawamoto H, Masai H, Miyatake S.
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Journal Title
The Journal of Immunology
Volume: 195
Issue: 3
Pages: 982-93
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Presentation] GATA3 and inflammatory disease2015
Author(s)
Shoichiro Miyatake
Organizer
International Symposium on Immune Regulation
Place of Presentation
Oharai Park Hotel, Oharai, Ibaraki
Year and Date
2015-10-29
Related Report
Int'l Joint Research / Invited
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