| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
ZNF131 is one of the BTB Zn finger family proteins. GATA3 is a transcription factor critically involved in many aspects of T cell differentiation and function as well as the development of various tissues such as mammary gland, kidney, inner ear etc. We identified ZNF131 as one of GATA3 binding proteins. ZNF131 is required for the expansion of thymocytes accompanied with the differentiation of double positive population. ZNF131 is also required for the proliferation of T cells upon TCR stimulation. ZNF131 is critical for the proliferation and gene rearrangement that take place during the pro B cell stage of B cell development. ZNF131 suppresses the expression of cdk inhibitor p21 (cdkn1a), thus it counteracts against the effect of tumor suppressor p53.
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