| Project/Area Number |
26460612
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical sociology
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
松永 健志 順天堂大学, 医学部, 准教授 (50445582)
池田 和隆 公益財団法人東京都医学総合研究所, 精神行動医学研究分野, 分野長 (60281656)
川越 いづみ 順天堂大学, 医学部, 准教授 (10445520)
井関 雅子 順天堂大学, 医学部, 教授 (80221076)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 肺がん / 開胸術後痛 / 術後遷延痛 / 危険因子 / 観察研究 / 術後痛 / 神経障害性痛 / 心理的要因 |
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| Outline of Final Research Achievements |
Fifteen patients who underwent thoracotomy for lung cancer were recruited. We analyzed the incidence of post-thoracotomy pain syndrome: PTPS, and predicting factors of PTPS. The incidence of PTPS two months after thoracic surgeries was 33%, and 13% of patients experienced severe pain (NRS≧5). These results are consistent with results of previous reports. The length of incision and duration of anesthesia/ surgery are found to be predicting factors, assuming that greater surgical stress would cause more inflammation and develop central sensitization which prolong pain.
A retrospective study was performed for patients who underwent lung cancer surgery at seven university hospitals in Japan in 2013. The prevalence of PTPS at 3 and 6 months were 18% and 12% after lung surgery. In multivariate logistic regression analysis, preoperative analgesic use was found to be associated with PTPS. Female gender was significantly associated with PTPS 6 months.
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