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Clinical significance of sarcopenia in cancer chemotherapy

Research Project

Project/Area Number 26460626
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Applied pharmacology
Research InstitutionNagoya University

Principal Investigator

Ando Yuichi  名古屋大学, 医学部附属病院, 教授 (10360083)

Co-Investigator(Kenkyū-buntansha) 満間 綾子  名古屋大学, 医学部附属病院, 病院講師 (10467326)
浦川 浩  名古屋大学, 医学部附属病院, 病院講師 (60584753)
下方 智也  名古屋大学, 医学部附属病院, 病院助教 (70612745)
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywordsサルコペニア / 分子標的治療薬 / がん薬物療法
Outline of Final Research Achievements

The aim of this study is investigated sarcopenia in cancer patients who underwent cancer chemotherapy in order to test the hypothesis that those patients with sarcopenia are more likely to experience severe toxicity and then poorly tolerate the treatment. First, we retrospectively analyzed the change of skeletal muscle mass in patients treated with an mTOR inhibitor and reported that the muscle mass was significantly reduced by treatment. Subsequently, an observational study was conducted to prospectively evaluate sarcopenia up to for 6 months in cancer patients who received a kinase inhibitor containing mTOR inhibitor. Of the 28 patients enrolled, 17 and 7 patients completed the 6-month and 3-month follow-ups, respectively. Final analysis of the results is in progress.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (5 results)

All 2016 2015

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results,  Acknowledgement Compliant: 2 results) Presentation (3 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Muscle wasting associated with the long-term use of mTOR inhibitors.2016

    • Author(s)
      Bishal Gyawali, Tomoya Shimokata, Kazunori Honda, Chihiro Kondoh, Naomi Hayashi, Yasushi Yoshino, Naoto Sassa, Yasuyuki Nakano, Momokazu Gotoh, Yuichi Ando.
    • Journal Title

      Mol Clin Oncol.

      Volume: 5 Issue: 5 Pages: 641-646

    • DOI

      10.3892/mco.2016.1015

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Low skeletal muscle density is associated with poor survival in patients with metastatic gastric cancer receiving chemotherapy.2016

    • Author(s)
      Nomi Hayashi, Yuichi Ando, Bishal Gyawali, Tomoya Shimokata, Osamu Maeda, Masahide Fukaya, Hidemi Goto, Masato Nagino and Yasuhiro Kodera.
    • Journal Title

      Oncol Rep

      Volume: 35 Issue: 3 Pages: 1727-1231

    • DOI

      10.3892/or.2015.4475

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Temsirolimus induced muscle loss.2016

    • Author(s)
      Bishal Gyawali, Tomoya Shimokata, Takefumi Mizutani, Osamu Maeda, Naoto Sassa, Yasushi Yoshino, Momokazu Gotoh, Yuichi Ando.
    • Organizer
      The 2nd Asian Conference for Frailty and Sarcopenia
    • Place of Presentation
      今池ガスビルホール(愛知県名古屋市)
    • Year and Date
      2016-11-04
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Loss of muscle mass associated with the long term use of mTOR inhibitors.2016

    • Author(s)
      Bishal Gyawali, Tomoya Shimokata, Kazunori Honda, Chihiro Kondoh, Naomi Hayashi, Yasushi Yoshino, Naoto Sassa, Yasuyuki Nakano, Momokazu Gotoh, Yuichi Ando
    • Organizer
      第14回日本臨床腫瘍学会学術集会
    • Place of Presentation
      神戸国際展示場・神戸国際会議場(兵庫県神戸市)
    • Year and Date
      2016-07-28
    • Related Report
      2016 Research-status Report
  • [Presentation] 進行再発胃がん患者における筋肉量評価について2015

    • Author(s)
      林直美、ビシャール・ギャワリ、下方智也、前田修、後藤秀実、梛野正人、小寺泰弘、安藤雄一.
    • Organizer
      第48回制癌剤適応研究会
    • Place of Presentation
      オークラアクトシティホテル浜松(浜松市)
    • Year and Date
      2015-03-20
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2019-03-29  

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