Safety of drugs inducing megalin in renal tubles using cadmium

• Project/Area Number: 26460631
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied pharmacology
• Research Institution: Osaka University of Pharmaceutical Sciences (2016); Jichi Medical University (2014-2015)
• Principal Investigator: Hosohata Keiko 大阪薬科大学, 薬学部, 准教授 (10547962)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 腎臓 / 尿細管 / カドミウム / エンドサイトーシス / 薬物有害反応 / 毒性 / 腎尿細管 / 創薬スクリーニング / 蓄積性 / エンドサイト―シス

Outline of Final Research Achievements

In this study, we found that the mRNA expressions of endocytic receptors in cultured cells, which are involved in reabsorption of cadmium in renal tubular cells, significantly increased and accompanied with increase in concentration of cadmium, resulting in cytotoxicity with exposure to several drugs.

Research Products

• [Journal Article] Effect of a dosing-time on quetiapine-induced acute hyperglycemia in mice. (2017)
  • Author(s): Kapse S, Ando H, Fujiwara Y, Suzuki C, Ushijima K, Kitamura H, Hosohata K, Kotani K, Shimba S, Fujimura A.
  • Journal Title: J Pharmacol Sci Volume: 133 Issue: 3 Pages: 139-145
  • DOI: 10.1016/j.jphs.2017.02.008
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Early prediction of cisplatin-induced nephrotoxicity by urinary vanin-1 in patients with urothelial carcinoma. (2016)
  • Author(s): Hosohata K, Washino S, Kubo T, Fujisaki A, Kurokawa S, Ando H, Fujimura A, Morita T.
  • Journal Title: Toxicology Volume: 359-360 Pages: 71-75
  • DOI: 10.1016/j.tox.2016.06.011
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Role of Oxidative Stress in Drug-Induced Kidney Injury. (2016)
  • Author(s): Hosohata K
  • Journal Title: Int J Mol Sci Volume: 17 Issue: 11 Pages: 1826-1826
  • DOI: 10.3390/ijms17111826
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Early urinary biomarkers for renal tubular damage in spontaneously hypertensive rats on a high salt intake. (2016)
  • Author(s): Hosohata K, Yoshioka D, Tanaka A, Ando H, Fujimura A.
  • Journal Title: Hypertens Res Volume: 39 Issue: 1 Pages: 19-26
  • DOI: 10.1038/hr.2015.103
  • Peer Reviewed / Open Access
• [Journal Article] Influence of genetic polymorphisms of multidrug and toxin extrusion protein 1 on its mRNA expression in peripheral blood cells. (2016)
  • Author(s): Ando H, Nakano K, Ushijima K, Kurokawa S, Washino S, Hosohata K, Morita T, Fujimura A.
  • Journal Title: J Pharmacol Sci Volume: in press Issue: 2 Pages: 138-140
  • DOI: 10.1016/j.jphs.2016.03.002
  • Peer Reviewed / Open Access
• [Journal Article] Association of decreased mRNA expression of multidrug and toxin extrusion protein 1 in peripheral blood cells with the development of flutamide-induced liver injury. (2015)
  • Author(s): Nakano K, Ando H, Kurokawa S, Hosohata K, Ushijima K, Takada M, Tateishi M, Yonezawa A, Masuda S, Matsubara K, Inui KI, Morita T, Fujimura A.
  • Journal Title: Cancer Chemother Pharmacol. Volume: ｉｎ ｐｒｅｓｓ Issue: 6 Pages: 1191-1197
  • DOI: 10.1007/s00280-015-2743-6
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Temsirolimus induces surfactant lipid accumulation and lung inflammation in mice. (2014)
  • Author(s): Washino S, Ando H, Ushijima K, Hosohata K, Kumazaki M, Mato N, Sugiyama Y, Kobayashi Y, Fujimura A, and Morita T.
  • Journal Title: Am J Physiol Lung Cell Mol Physiol. Volume: 306 Issue: 12 Pages: L1117-L1128
  • DOI: 10.1152/ajplung.00251.2013
  • Peer Reviewed / Open Access