| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
To clarify the effect of ADLH2 polymorphism on the brain, we conducted brain imaging studies on alcoholics with and without inactive ALDH2 and age-matched healthy volunteers. From these subjects, T1-weighted images were obtained by 3-dimensional volumetric magnetization prepared rapid gradient echo (MPRAGE) sequences, and the data were analyzed by voxel-based morphometry using statistical parametric mapping software. The gray matter volume of the alcoholics was lower than that of the controls and it was negatively correlated with age in both groups. A comparison between the ALDH2*2/*1 patient group and ALDH2*1/*1 group revealed that hippocampal and parahippocampal atrophy was more severe in the ALDH2*2/*1 group. The results suggested that alterations in alcohol metabolism by the ALDH2*2 allele promote hippocampal and parahippocampal atrophy in alcoholics. The possible mechanism may be the neurotoxic effect of acetaldehyde, leading to cognitive dysfunction in alcoholics in later life.
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