Effect of ALDH2 polymorphism on brain atrophy in alcoholic patients: A matched-pair MRI study by voxel-based morphometric analysis
| Project/Area Number |
26460632
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied pharmacology
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| Research Institution | 独立行政法人国立病院機構(久里浜医療センター臨床研究部) (2016-2017)
Kyorin University (2014-2015) |
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Principal Investigator |
Matsui Toshifumi 独立行政法人国立病院機構(久里浜医療センター臨床研究部), その他部局等, 医師 (50333802)
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| Co-Investigator(Kenkyū-buntansha) |
樋口 進 独立行政法人国立病院機構(久里浜医療センター臨床研究部), その他部局等, 院長 (40156576)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | アルコール依存症 / アセトアルデヒド / アセトアルデヒド脱水素酵素２ / ALDH2多型 / MRI / 海馬 / ウェルニッケコルサコフ症候群 / 脳血流検査 / 後部帯状回 / 多型 / alcoholics / acetaldehyde / hippocampus / Wernicke / Korsakoff / パペッツ回路 / voxel-based morphometry |
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| Outline of Final Research Achievements |
To clarify the effect of ADLH2 polymorphism on the brain, we conducted brain imaging studies on alcoholics with and without inactive ALDH2 and age-matched healthy volunteers. From these subjects, T1-weighted images were obtained by 3-dimensional volumetric magnetization prepared rapid gradient echo (MPRAGE) sequences, and the data were analyzed by voxel-based morphometry using statistical parametric mapping software. The gray matter volume of the alcoholics was lower than that of the controls and it was negatively correlated with age in both groups. A comparison between the ALDH2*2/*1 patient group and ALDH2*1/*1 group revealed that hippocampal and parahippocampal atrophy was more severe in the ALDH2*2/*1 group. The results suggested that alterations in alcohol metabolism by the ALDH2*2 allele promote hippocampal and parahippocampal atrophy in alcoholics. The possible mechanism may be the neurotoxic effect of acetaldehyde, leading to cognitive dysfunction in alcoholics in later life.
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Report
(5 results)
Research Products
(23 results)
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[Journal Article] Macrocytosis, Macrocytic Anemia, and Genetic Polymorphisms of Alcohol Dehydrogenase-1B and Aldehyde Dehydrogenase-2 in Japanese Alcoholic Men2014
Author(s)
Yokoyama A, Yokoyama T, Brooks PJ, Mizukami T, Matsui T, Kimura M, Matsushita S, Higuchi S, Maruyama K
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Journal Title
Alcohol Clin Exp Res
Volume: 38
Issue: 5
Pages: 1237-1246
DOI
Related Report
Peer Reviewed
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[Journal Article] Efficacy of disulfiram for the treatment of alcohol dependence assessed with a multicenter randomized controlled trial2014
Author(s)
Yoshimura A, Kimura M, Nakayama H, Matsui T, Okudaira F, Akazawa S, Ohkawara M, Cho T, Kono Y, Hashimoto K, Kumagai M, Sahashi Y, Roh S, Higuchi S
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Journal Title
Alcohol Clin Exp Res
Volume: 38
Issue: 2
Pages: 572-578
DOI
Related Report
Peer Reviewed
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[Journal Article] Alcoholic Ketosis: Prevalence, Determinants, and Ketohepatitis in Japanese Alcoholic Men2014
Author(s)
Yokoyama A, Yokoyama T, Mizukami T, Matsui T, Shiraishi K, Kimura M, Matsushita S, Higuchi S, Maruyama K
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Journal Title
Alcohol Alcohol
Volume: 49
Issue: 6
Pages: 618-625
DOI
Related Report
Peer Reviewed
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