| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
Recent studies have demonstrated that Chronic kidney disease (CKD) contributes to cognitive dysfunction. The hippocampus has been shown to play a critical role in the formation of new memories. The present study investigated the expression of stress-associated proteins in the hippocampus of CKD mice. The levels of 4-hydroxynonenal-adducted proteins, the makers of lipid peroxidation, in the hippocampus of CKD mice were significantly increased at 8 weeks after 5/6 nephrectomy. Moreover, an increase of 78-kDa glucose-regulated protein, an indicator of Endoplasmic Reticulum (ER) stress, was detected in the hippocampus. These results suggest that not only oxidative stress but also ER stress contributes to cognitive dysfunction in CKD mice.
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