Modifications of hippocampal dysfunction in diabetic mice by chronic kidney failure: Involvement of endoplasmic reticulum stress
Project/Area Number |
26460634
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Applied pharmacology
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Research Institution | Nihon University |
Principal Investigator |
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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Keywords | 小胞体ストレス / 海馬 / 脂質過酸化物 / 慢性腎不全 / シャペロンタンパク質 / Blood Urea Nitrogen / Creatinine / 大脳皮質 / 小脳 / 酸化ストレス / CHOP / 腎不全 / シャペロン |
Outline of Final Research Achievements |
Recent studies have demonstrated that Chronic kidney disease (CKD) contributes to cognitive dysfunction. The hippocampus has been shown to play a critical role in the formation of new memories. The present study investigated the expression of stress-associated proteins in the hippocampus of CKD mice. The levels of 4-hydroxynonenal-adducted proteins, the makers of lipid peroxidation, in the hippocampus of CKD mice were significantly increased at 8 weeks after 5/6 nephrectomy. Moreover, an increase of 78-kDa glucose-regulated protein, an indicator of Endoplasmic Reticulum (ER) stress, was detected in the hippocampus. These results suggest that not only oxidative stress but also ER stress contributes to cognitive dysfunction in CKD mice.
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Report
(4 results)
Research Products
(12 results)
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[Journal Article] Increased Expression of 15-Hydroxyprostaglandin Dehydrogenase in Spinal Astrocytes During Disease Progression in a Model of Amyotrophic Lateral Sclerosis.2017
Author(s)
Miyagishi H, Kosuge Y, Takano A, Endo M, Nango H, Yamagata-Murayama S, Hirose D, Kano R, Tanaka Y, Ishige K, Ito Y.
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Journal Title
Cell Mol Neurobiol
Volume: 37(3)
Issue: 3
Pages: 445-452
DOI
Related Report
Peer Reviewed
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