Development of orally active zinc complexes enhancing and controlling the function of endogenous insulin as a novel anti-diabetic candidate
Project/Area Number |
26460636
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Applied pharmacology
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Research Institution | Kyoto Pharmaceutical University |
Principal Investigator |
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | 糖尿病治療薬 / 膵β細胞保護薬 / 糖尿病予防 / 亜鉛錯体 / インスリン抵抗性改善 / Aktリン酸化作用 / PTEN阻害作用 / GPCR作動作用 / Aktリン酸化作用 / インスリン様作用 / 糖尿病治療 / ホスファターゼ阻害 |
Outline of Final Research Achievements |
Diabetes mellitus is a disease mainly with hyperglycemia, and its patients are increasing year by year. Many types of anti-diabetic medicines are clinically used, however, severe side effects such as hypoglycemia have been reported, and especially there is no therapeutic medicines protecting the pancreatic beta cell in the present. Zinc (Zn) ion is well known to have the insulin-mimetic activity, and thus we primarily intended to elucidate the action mechanism of insulin-mimetic Zn-complexes in terms of relatively higher safety and effect of Zn-complexes. Zn-complexes were found to act independently from endogenous insulin as like supporting and enhancing insulin function, that is, Zn-complexes increased the cellular insulin-signal because they inhibited both the PTP1B and PTEN, and thus enhanced Akt phosphorylation in the insulin-signal transduction pathway after uptake into adipocytes.
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Report
(4 results)
Research Products
(41 results)
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[Journal Article] Oral treatment with a zinc complex of acetylsalicylic acid prevents diabetic cardiomyopathy in a rat model of type-2 diabetes: activation of the Akt pathway.2016
Author(s)
Sevil Korkmaz-Icoz, Samer Al Said, Tamas Radovits, Shiliang Li, Maik Brune, Peter Hegedus, Ayhan Atmanli, Mihaly Ruppert, Paige Brlecic, Lorenz Heyne Lehmann, Bernd Lahrmann, Niels Grabe, Yutaka Yoshikawa, Hiroyuki Yasui, Patrick Most, Matthias Karck, and Gabor Szabo
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Journal Title
Cardiovasc. Diabetol.
Volume: 15
Issue: 1
Pages: 75-87
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Administration of zinc complex of acetylsalicylic acid after the onset of myocardial injury protects the heart by upregulation of antioxidant enzymes.2016
Author(s)
Sevil Korkmaz-Icoz, Ayhan Atmanli, Tamas Radovits, Shiliang Li, Peter Hegedus, Mihaly Ruppert, Paige Brlecic, Yutaka Yoshikawa, Hiroyuki Yasui, Matthias Karck, and Gabor Szabo
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Journal Title
J. Physiol. Sci.
Volume: 66
Issue: 2
Pages: 113-125
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Superiority of zinc complex of acetylsalicylic acid to acetylsalicylic acid in preventing postischemic myocardial dysfunction.2015
Author(s)
1) Sevil Korkmaz, Ayhan Atmanli, Shiliang Li, Tamás Radovits, Peter Hegedűs, Enikő Barnucz, Kristóf Hirschberg, Sivakkanan Loganathan, Yutaka Yoshikawa, Hiroyuki Yasui, Matthias Karck and Gábor Szabó
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Journal Title
Exper. Biol. Med.
Volume: 240
Pages: 1247-1255
Related Report
Peer Reviewed / Int'l Joint Research
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