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Elucidation of the pathophysiological mechanism of neurodevelopmental disorder by the early postnatal stress and its novel pharmacotherapeutic strategy

Research Project

Project/Area Number 26460637
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Applied pharmacology
Research InstitutionNagasaki International University

Principal Investigator

YAMAGUCHI Taku  長崎国際大学, 薬学部, 准教授 (80325563)

Co-Investigator(Renkei-kenkyūsha) FUKUMORI Ryo  長崎国際大学, 薬学部, 助教 (60713774)
YAMAMOTO Tsuneyuki  長崎国際大学, 薬学部, 教授 (20091332)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords幼若期ストレス / 神経発達障害 / 自閉症 / 抑うつ行動 / 幼児・児童虐待 / HPA axis / 薬物治療 / 行動薬理学 / 幼齢期ストレス / 精神発達障害 / 社会的行動 / 精神疾患
Outline of Final Research Achievements

This study aimed at elucidating the pathophysiological mechanisms and establishing its preclinical drug evaluation for novel pharmacotherapy in the neurodevelopmental disorder, by investigating the validity as an animal model in rats experienced with pharmacological stress (namely ACTH administration) during early postnatal period. The findings in this study suggest that the pharmacological stress during early postnatal period might produce the behavioral abnormalities such as cognitive impairments, anxiety-like and depressive-like behaviors in adulthood but not adolescent, with a critical developmental period. Those behavioral susceptibilities by pharmacological stress during early postnatal period after growth are possibly implicated in a dysregulation of the neuroendocrine system via hypothalamo-pituitary-adrenal (HPA) axis induced by adrenomegaly and dysfunction of the serotonergic/GABAergic neuronal systems in the raphe nuclei.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (27 results)

All 2017 2016 2015 2014 Other

All Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (23 results) (of which Int'l Joint Research: 5 results,  Invited: 2 results) Remarks (2 results)

  • [Journal Article] Neuronal codes for the inhibitory control of impulsive actions in the rat infralimbic cortex2016

    • Author(s)
      Tsutsui-Kimura I., Ohmura Y., Izumi T., Matsushima T., Amita H., Yamaguchi T., Yoshida T, Yoshioka M.
    • Journal Title

      Behavioural Brain Research

      Volume: 296 Pages: 361-372

    • DOI

      10.1016/j.bbr.2015.08.025

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] うつ病モデル動物を用いての抗うつ薬、特にSSRIの行動薬理学的特性2015

    • Author(s)
      山本経之、山口 拓
    • Journal Title

      臨床精神薬理

      Volume: 18 Pages: 145-155

    • Related Report
      2014 Research-status Report
  • [Presentation] カンナビノイドCB1受容体の慢性的なメタンフェタミン投与後における認知機能障害発現への関与2017

    • Author(s)
      福森 良、山口 拓、山本経之
    • Organizer
      第90回日本薬理学会年会
    • Place of Presentation
      長崎
    • Year and Date
      2017-03-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] 幼若期薬理学的ストレスによる成長後の抑うつ様行動2017

    • Author(s)
      山口 拓、松元秀憲、前田ふみ、福森 良、山本経之
    • Organizer
      第90回日本薬理学会年会
    • Place of Presentation
      長崎
    • Year and Date
      2017-03-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] 幼若期薬理学的ストレス負荷ラットにおける成長後の抑うつ様行動2016

    • Author(s)
      山口 拓、松元秀憲、前田ふみ、福森 良、山本経之
    • Organizer
      第69回日本薬理学会西南部会
    • Place of Presentation
      松山
    • Year and Date
      2016-11-26
    • Related Report
      2016 Annual Research Report
  • [Presentation] Early life stress-induced morphological changes in the hippocampus and increased sociability in adult rats: possible implication of the serotonergic system.2016

    • Author(s)
      Kumamoto H., Yamaguchi T., Yoshioka M.
    • Organizer
      The 29th ECNP (European College of Neuropsychopharmacology) Congress
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      2016-09-17
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Anxiety-like and depressive-like behaviors in rats administered ACTH during early postnatal period.2016

    • Author(s)
      Yamaguchi T., Fukumori R, Yoshioka M, Yamamoto T:
    • Organizer
      The 30th Collegium Internationale Neuro-psychopharmacologicum (CINP) World Congress
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2016-07-03
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Possible involvement of cannabinoid CB1 receptors in behavioral impairments after withdrawal from chronic methamphetamine administration in mice.2016

    • Author(s)
      Fukumori R, Ledent C, Yamada S, Yamaguchi T., Yamamoto T:
    • Organizer
      The 30th Collegium Internationale Neuro-psychopharmacologicum (CINP) World Congress
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2016-07-03
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] メタンフェタミン慢性投与後の認知機能障害発現における内在性カンナビノイドシステムの関与2016

    • Author(s)
      福森 良、山口 拓、山本経之
    • Organizer
      第89回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-03-18
    • Related Report
      2015 Research-status Report
  • [Presentation] 幼若期薬理学的ストレスによる成長後の不安様・抑うつ様行動2016

    • Author(s)
      山口 拓、福森 良、吉岡充弘、山本経之
    • Organizer
      第89回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-03-18
    • Related Report
      2015 Research-status Report
  • [Presentation] 幼若期ACTH反復投与による成長後の行動変容2015

    • Author(s)
      山口 拓、福森 良、山本経之
    • Organizer
      第32回日本薬学会九州支部大会
    • Place of Presentation
      延岡
    • Year and Date
      2015-11-28
    • Related Report
      2015 Research-status Report
  • [Presentation] 若期薬理学的ストレス負荷ラットにおける成長後の不安様・抑うつ様行動2015

    • Author(s)
      山口 拓、福森 良、吉岡充弘、山本経之
    • Organizer
      第68回日本薬理学会西南部会
    • Place of Presentation
      下関
    • Year and Date
      2015-11-21
    • Related Report
      2015 Research-status Report
  • [Presentation] 幼若期薬理学的ストレスによる成長後の情動行動変容2015

    • Author(s)
      山口 拓、松本秀憲、福森 良、吉岡充弘、山本経之
    • Organizer
      第45回日本神経精神薬理学会・第37回日本生物学的精神医学会合同年会
    • Place of Presentation
      東京
    • Year and Date
      2015-10-24
    • Related Report
      2015 Research-status Report
  • [Presentation] Establishment of a behavioral-pharmacological evaluation on social interaction behavior using a 3-chamber system for rats2015

    • Author(s)
      Yamaguchi T., Fukumori R, Yoshioka M, Yamamoto T
    • Organizer
      Society for neuroscience 45th annual meeting
    • Place of Presentation
      Chicago
    • Year and Date
      2015-10-17
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Involvement of endocannabinoid system on cognitive dysfunction during withdrawal of repeated methamphetamine administration in mice2015

    • Author(s)
      Fukumori R, Yamada S, Yamaguchi T., Yamamoto T
    • Organizer
      Society for neuroscience 45th annual meeting
    • Place of Presentation
      Chicago
    • Year and Date
      2015-10-17
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 幼若期ストレスによる成長後の行動変容2015

    • Author(s)
      山口 拓、吉岡充弘、山本経之
    • Organizer
      第45回日本神経精神薬理学会・第37回日本生物学的精神医学会合同年会
    • Place of Presentation
      東京
    • Year and Date
      2015-09-24
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 幼若期ACTH反復投与ラットにおける成長後の抑うつ様行動2015

    • Author(s)
      山口 拓、松本秀憲、福森 良、山本経之
    • Organizer
      次世代を担う創薬・医療薬理シンポジウム2015
    • Place of Presentation
      東京
    • Year and Date
      2015-08-29
    • Related Report
      2015 Research-status Report
  • [Presentation] 幼若期薬理学的ストレス負荷ラットの行動特性2015

    • Author(s)
      山口 拓、吉岡充弘、山本経之
    • Organizer
      第88回日本薬理学会年会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-03-18 – 2015-03-20
    • Related Report
      2014 Research-status Report
  • [Presentation] 行動薬理学的概論「はじめての行動薬理学」2015

    • Author(s)
      山口 拓
    • Organizer
      第88回日本薬理学年会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-03-18
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 幼若期ストレスによる成長後の社会的行動障害2014

    • Author(s)
      山口 拓、山本経之、吉岡充弘
    • Organizer
      第 31回日本薬学会九州支部大会
    • Place of Presentation
      福岡
    • Year and Date
      2014-12-06 – 2014-12-07
    • Related Report
      2014 Research-status Report
  • [Presentation] 幼若期ACTH反復投与ラットの行動学的特性2014

    • Author(s)
      山口 拓、吉岡充弘、山本経之
    • Organizer
      第67回日本薬理学会西南部会
    • Place of Presentation
      北九州
    • Year and Date
      2014-11-23
    • Related Report
      2014 Research-status Report
  • [Presentation] 注意欠如・多動性障害(ADHD)モデルにおける側坐核ドパミン作動性神経の機能的役割2014

    • Author(s)
      平出幸子、田端信護、山口 拓、千里内隆行、柳川芳毅、島村佳一、吉岡充弘、富樫廣子
    • Organizer
      第23回日本臨床精神神経薬理学会・第43回日本神経精神薬理学会合同年会
    • Place of Presentation
      名古屋
    • Year and Date
      2014-11-20 – 2014-11-22
    • Related Report
      2014 Research-status Report
  • [Presentation] 幼若期ストレスによるラットの社会行動障害とfluvoxamine反復投与の効果2014

    • Author(s)
      隈元晴子、山口 拓、今野幸太郎、大村 優、吉田隆行、泉 剛、吉岡充弘
    • Organizer
      第65回日本薬理学会北部会
    • Place of Presentation
      福島
    • Year and Date
      2014-09-26 – 2014-09-27
    • Related Report
      2014 Research-status Report
  • [Presentation] 幼若期ストレスによる成熟後のsocial interaction 行動障害に対するfluvoxamine反復投与の効果2014

    • Author(s)
      隈元晴子、山口 拓、大村 優、吉田隆行、泉 剛、吉岡充弘
    • Organizer
      第130回日本薬理学会関東部会
    • Place of Presentation
      東京
    • Year and Date
      2014-07-05
    • Related Report
      2014 Research-status Report
  • [Presentation] Establishment of a social interaction test using a 3-chamber system for rats2014

    • Author(s)
      Yamaguchi T., Jingushi H, Fukumori R, Yoshioka M, Yamamoto T
    • Organizer
      The 29th Collegium Internationale Neuro-psychopharmacologicum (CINP) World Congress
    • Place of Presentation
      Vancouver, Canada
    • Year and Date
      2014-06-22 – 2014-06-26
    • Related Report
      2014 Research-status Report
  • [Remarks] 長崎国際大学 教員・研究紹介

    • URL

      http://www1.niu.ac.jp/about/teacher/detail.html?data[id]=250

    • Related Report
      2016 Annual Research Report 2015 Research-status Report 2014 Research-status Report
  • [Remarks] 長崎国際大学薬学部薬理学研究室ホームページ

    • URL

      http://www.niu.ac.jp/~pharm1/lab/pharmacology/pharmacology.html

    • Related Report
      2016 Annual Research Report 2015 Research-status Report 2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

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