| Project/Area Number |
26460642
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
TOZUKA MINORU 東京医科歯科大学, 大学院保健衛生学研究科, 教授 (60431954)
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| Co-Investigator(Kenkyū-buntansha) |
大川 龍之介 東京医科歯科大学, 大学院保健衛生学研究科, 助教 (50420203)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | HDL / 酸化LDL / コレステロール引き抜き能 / 抗酸化作用 / 抗炎症作用 / apolipoprotein A-I / myeloperoxidase / paraoxonase 1 / paraoxonase1 / N-ホモシステイン化 / High-density lipoprotein / Chymase / apoE含有HDL / SAA |
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| Outline of Final Research Achievements |
It is believed that the estimation of the functions of high-density lipoprotein (HDL), anti-atherosclerotic lipoprotein, is essential for medical treatment and prevention of cardiovascular disease. In the present study, we clarified a part of the mechanism of anti-atherosclerotic functions, such as cholesterol efflux capacity, anti-inflammation, and antioxidant ability, induced by HDL. In addition, we indicated that the result of cholesterol efflux capacity given an opposite interpretation was occasionally obtained by using slightly different conditions in the assay procedure accepted widely. These observations could be important to standardize the assay methods for the estimation of the functions of HDL.
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