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Clinical application of p62/SQSTM1 in cancers

Research Project

Project/Area Number 26460648
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Laboratory medicine
Research InstitutionShiga University of Medical Science

Principal Investigator

Okabe Hidetoshi  滋賀医科大学, 医学部, 名誉教授 (70079713)

Co-Investigator(Kenkyū-buntansha) 茶野 徳宏  滋賀医科大学, 医学部, 准教授 (40346028)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsp62/SQSTM1 / RB1CC1 / biomarker / 放射線治療 / 代謝 / epigenome / mitochondria / 腎癌 / 骨肉腫 / バイオマーカー / 肺癌 / 頭頸部癌
Outline of Final Research Achievements

Hypopharyngeal carcinoma is one of the worst prognostic malignancies among head and neck carcinomas. Therefore, a good biomarker should be identified to predict the best therapeutic option before starting the treatment. In cell models, p62/SQSTM1 levels affected the Nrf2-Keap1 pathway, ROS levels, GSH/GSSG ratios and cell growth, especially under irradiation rather than under CDDP exposure, which was toxic despite p62/SQSTM1 status. In a clinical cohort of hypopharyngeal carcinomas, high levels of p62/SQSTM1 significantly predicted poor prognosis (log-rank test, Chi-square value = 6.750, p = 0.0094) and maximum critical risk (Cox proportional hazard ratio = 4.405, p = 0.0086), especially in the radiotherapy group. Therefore, when p62/SQSTM1 is elevated in the biopsy section, hypopharyngeal carcinoma should be treated with surgical and/or chemotherapeutic options.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (11 results)

All 2017 2016 2015 2014

All Journal Article (7 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 7 results,  Open Access: 7 results,  Acknowledgement Compliant: 5 results) Presentation (2 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] p62/SQSTM1 levels predicts radiotherapy resistance in hypopharyngeal carcinomas.2017

    • Author(s)
      Arai A, Chano T, Ikebuchi K, Hama Y, Ochi Y, Tameno H, Shimada T.
    • Journal Title

      Am J Cancer Res.

      Volume: 7(4) Pages: 881-891

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Hydroxyl-HIF2-alpha is potential therapeutic target for renal cell carcinomas.2016

    • Author(s)
      Isono T, Chano T, Yoshida T, Kageyama S, Kawauchi A, Suzaki M, Yuasa T.
    • Journal Title

      Am J Cancer Res.

      Volume: 6(10) Pages: 2263-2276

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Tumour-specific metabolic adaptation to acidosis is coupled to epigenetic stability in osteosarcoma cells.2016

    • Author(s)
      Chano T, Avnet S, Kusuzaki K, Bonuccelli G, Sonveaux P, Rotili D, Mai A, Baldini N.
    • Journal Title

      Am J Cancer Res

      Volume: 6(4) Pages: 859-875

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Therapeutic inhibition of mitochondrial function induces cell death in starvation-resistant renal cell carcinomas.2016

    • Author(s)
      Isono T, Chano T, Yonese J, Yuasa T.
    • Journal Title

      Sci Rep

      Volume: 6 Issue: 1 Pages: 25669-25669

    • DOI

      10.1038/srep25669

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Mammalian autophagy is essential for hepatic and renal ketogenesis during starvation.2016

    • Author(s)
      Takagi A, Kume S, Kondo M, Nakazawa J, Chin-Kanasaki M, Araki H, Araki S, Koya D, Haneda M, Chano T, Matsusaka T, Nagao K, Adachi Y, Chan L, Maegawa H, Uzu T.
    • Journal Title

      Sci Rep

      Volume: 6 Issue: 1 Pages: 18944-18944

    • DOI

      10.1038/srep18944

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Dimethyl sulfoxide induces chemotherapeutic resistance in the treatment of testicular embryonal carcinomas.2015

    • Author(s)
      Kita H, Okamoto K, Kushima R, Kawauchi A, Chano T.
    • Journal Title

      Oncol Lett

      Volume: 10(2) Pages: 661-666

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Glucose deprivation induces G2/M transition-arrest and cell death in N-GlcNAc2-modified protein-producing renal carcinoma cells.2014

    • Author(s)
      Isono T, Chano T, Kitamura A, Yuasa T.
    • Journal Title

      PLoS One.

      Volume: 9(5) Issue: 5 Pages: e96168-e96168

    • DOI

      10.1371/journal.pone.0096168

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Tumour-specific metabolic adaptation to acidosis is coupled to epigenetic stability in osteosarcoma cells.2016

    • Author(s)
      132.Chano T, Avnet S, Kusuzaki K, Mai A, Baldini N.
    • Organizer
      EORS 2016 (European Orthopaedic Research Society)
    • Place of Presentation
      Bologna, Italy
    • Year and Date
      2016-09-14
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Tumour-specific metabolic adaptation to acidosis is coupled to epigenetic stability in osteosarcoma cells. (Keynote lecture)2015

    • Author(s)
      Chano T.
    • Organizer
      ISCaM2015 (2nd Annual Meeting of the International Society of Cancer Metabolism)
    • Place of Presentation
      San Servolo, Venice, Italy
    • Year and Date
      2015-09-16
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Patent(Industrial Property Rights)] 癌の検査方法、癌細胞増殖阻害剤、抗癌剤及び抗癌剤のスクリーニング方法2015

    • Inventor(s)
      茶野徳宏
    • Industrial Property Rights Holder
      茶野徳宏
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2015-123952
    • Filing Date
      2015-06-19
    • Related Report
      2015 Research-status Report
  • [Patent(Industrial Property Rights)] 頭頸部癌及び食道癌用抗癌剤及び増強剤2014

    • Inventor(s)
      茶野徳宏、島田剛敏、二見和伸、古市泰宏
    • Industrial Property Rights Holder
      茶野徳宏、島田剛敏、二見和伸、古市泰宏
    • Industrial Property Rights Type
      特許
    • Filing Date
      2014-11-12
    • Acquisition Date
      2015-06-19
    • Related Report
      2015 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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