• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Reguration mechanism of a new gene HMGA2 in thyroid tumors

Research Project

Project/Area Number 26460653
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Laboratory medicine
Research InstitutionDokkyo Medical University

Principal Investigator

Hishinuma Akira  獨協医科大学, 医学部, 教授 (40201727)

Co-Investigator(Kenkyū-buntansha) 小飼 貴彦  獨協医科大学, 医学部, 准教授 (40711693)
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
KeywordsHMGA2 / 甲状腺癌 / 甲状腺濾胞癌 / 病理診断 / トランスクリプトーム / 甲状腺 / 腫瘍 / 発癌 / 遺伝子 / サイログロブリン / 細胞増殖関連遺伝子 / サイログロブリン異常症 / 甲状腺腫瘍 / 免疫染色 / 濾胞癌 / 未分化癌 / 乳頭癌 / 転移 / 発癌機序
Outline of Final Research Achievements

Recent studies have drawn attention to a nuclear protein HMGA2, abundantly expressed in the mesenchyme, as a differentiation marker in epithelial tumor cells. In this study, we demonstrated selective expression of HMGA2 in malignant tumor tissues, among various types of thyroid tissue, by using immuno-histochemical staining (IHC). Our results raised a possibility that the IHC of HMGA2 in surgical specimens of follicular thyroid cancer brings about more reliable diagnosis, differentiated from benign follicular adenoma, as well as prediction of its prognosis. In addition, our transcriptome analysis in thyroid cancer cell lines supported our hypothesis that pathogenic variants of thyroglobulin promote tumor development through the induction of HMGA2 followed by several oncogenic gene expressions.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (4 results)

All 2017 2014

All Presentation (4 results) (of which Int'l Joint Research: 2 results)

  • [Presentation] Expression of a Cell Differentiation Marker HMGA2 in Thyroid Cancer Tissues in Japan2017

    • Author(s)
      Kogai T, Hirokawa M, Fukushima M, Sakumoto J, Kobayashi K, Fukata F, Akira Miyauchi A, Hirabayashi H, Hishinuma A
    • Organizer
      The 12th Asia and Oceania Thyroid Association Congress
    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] POTENTIAL OF HMGA2 IMMUNO-HISTOCHEMICAL STAINING AS A PROGNOSTIC MARKER OF METASTATIC RECURRENCE IN FOLLICULAR THYROID CANCER2017

    • Author(s)
      Kogai T, Sakumoto J, Konno W, Kanaya H, Hirabayashi H, Hishinuma A.
    • Organizer
      87th Annual Metting of the American Thyroid Association
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 甲状腺癌における細胞分化マーカーHMGA2の発現の検討2014

    • Author(s)
      小飼貴彦、廣川満良、福島光浩、作本順子、小林 薫、深田修司、宮内 昭、菱沼 昭
    • Organizer
      第61回日本臨床検査医学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2014-11-23
    • Related Report
      2014 Research-status Report
  • [Presentation] 甲状腺癌における細胞分化マーカーHMGA2の発現の検討2014

    • Author(s)
      小飼貴彦、廣川満良、福島光浩、作本順子、小林 薫、深田修司、宮内 昭、菱沼 昭
    • Organizer
      第57回日本甲状腺学会
    • Place of Presentation
      大阪
    • Year and Date
      2014-11-14
    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2019-03-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi