| Project/Area Number |
26460658
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
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| Research Collaborator |
KOBAYASHI YUKIHARU アドテック株式会社, 研究開発部
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 甲状腺乳頭がん / 検査システム / ナノビーズ / イムノクロマト / モノクローナル抗体 / 診断システム |
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| Outline of Final Research Achievements |
Thyroid carcinoma is one of the favorable prognostic malignancies in human body. For the reason, early diagnosis and treatment are important. While thyroid is easily reached by physical examination, the disease is generally diagnosed by ultrasound and fine needle aspiration (FNA). However, both methods have limitations. My group established a monoclonal antibody for thyroid carcinoma and presented the diagnostic effectiveness by immunostaining. Whereas the result was obtained mainly by histological examination, the antigen was also present in blood. In current study, thermoresponsive magnetic nanoparticles with lower critical solution temperature (LCST) in aqueous solution, was conjugated to the antibody for the application of the antibody for blood screening. Also conjugation for immunochromatography was performed. Using these tools, the antibody may contribute to handy and more reliable screening of thyroid papillary carcinoma patients.
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