Exploration of HDL functional measurement as a novel biomarker for atherosclerosis

• Project/Area Number: 26460664
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Laboratory medicine
• Research Institution: Fukuoka University
• Principal Investigator: Bo Zhang 福岡大学, 医学部, 准教授 (80352251)
• Co-Investigator(Kenkyū-buntansha): 三浦 伸一郎 福岡大学, 医学部, 准教授 (20343709) ; 朔 啓二郎 福岡大学, 医学部, 教授 (40183371) ; 今泉 聡 福岡大学, 医学部, 准教授 (60609478) ; 岩田 敦 福岡大学, 医学部, 講師 (00412586)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 高比重リポ蛋白 / 動脈硬化病変 / 血管内超音波 / 多変量データ解析 / 冠動脈硬化 / リポタンパク質 / HDL / プラーク / IVUS / 糖尿病 / 動脈硬化 / 虚血性心疾患 / リポ蛋白 / LDL / リン脂質 / リポ蛋白質 / スフィンゴミエリン / HDL亜分画 / キャピラリー等速電気泳動 / 高コレステロール血症

Outline of Final Research Achievements

This study examined the association between the HDL functionality and coronary atherosclerosis, as assessed by intravascular ultrasound (IVUS), in patients with stable coronary artery disease (SCAD) who had type 2 diabetes mellitus (T2DM), using multivariate data analysis (MVDA). HDL efflux capacity and HDL inflammatory index were used as functional measurement of HDL. Coronary plaque volume/area and composition of target lesion were measured using gray-scale IVUS and IB-IVUS. OPLS (orthogonal partial squares projections of latent structures) model indicated that HDL inflammatory index was associated with both the fibrosis content and the thickness of fibrous cap of coronary plaque, while HDL efflux capacity and apolipoprotein A-1, the major protein of HDL, was mainly associated with the fibrosis content of coronary plaque. This finding suggests that HDL function is related to the vulnerability of coronary plaque in SCAD patients with T2DM..

Research Products

• [Journal Article] Is a bare-metal stent still useful for improving the outcome of percutaneous coronary intervention? From the FU-Registry (2017)
  • Author(s): GONDO, K., IKE, A., OGAWA, M., SHIRAI, K., SUGIHARA, M., NISHIKAWA, H., IWATA, A., KAWAMURA, A., MORI, K., ZHANG, B., MIURA, S., YASUNAGA, S. & SAKU, K.
  • Journal Title: J Cardiol Volume: 69 Issue: 4 Pages: 652-659
  • DOI: 10.1016/j.jjcc.2016.06.009
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Evaluation of the antithrombotic abilities of non-vitamin K antagonist oral anticoagulants using the Total Thrombus-formation Analysis System(R) (2017)
  • Author(s): IDEMOTO, Y., MIURA, S. I., NORIMATSU, K., SUEMATSU, Y., HITAKA, Y., SHIGA, Y., MORII, J., IMAIZUMI, S., KUWANO, T., IWATA, A., ZHANG, B., OGAWA, M. & SAKU, K.
  • Journal Title: Heart Vessels Volume: 32 Issue: 3 Pages: 309-316
  • DOI: 10.1007/s00380-016-0864-4
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] A Blend of Sesame and Rice Bran Oils Lowers Hyperglycemia and Improves the Lipids (2016)
  • Author(s): DEVARAJAN, S., CHATTERJEE, B., URATA, H., ZHANG, B., ALI, A., SINGH, R. & GANAPATHY, S.
  • Journal Title: Am J Med Volume: 129 Issue: 7 Pages: 731-9
  • DOI: 10.1016/j.amjmed.2016.02.044
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] A blend of sesame oil and rice bran oil lowers blood pressure and improves the lipid profile in mild-to-moderate hypertensive patients (2016)
  • Author(s): DEVARAJAN, S., SINGH, R., CHATTERJEE, B., ZHANG, B. & ALI, A.
  • Journal Title: J Clin Lipidol Volume: 10 Issue: 2 Pages: 339-49
  • DOI: 10.1016/j.jacl.2015.12.011
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Retigabine, a Kv7.2/Kv7.3-Channel Opener, Attenuates Drug-Induced Seizures in Knock-In Mice Harboring Kcnq2 Mutations (2016)
  • Author(s): Yukiko Ihara, Yuko Tomonoh, Masanobu Deshimaru, Bo Zhang, Taku Uchida, Atsushi Ishii, Shinichi Hirose
  • Journal Title: PLoS One Volume: 11 Issue: 2 Pages: e0150095-e0150095
  • DOI: 10.1371/journal.pone.0150095
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Paradoxical nocturnal elevation of sympathetic tone and spontaneous ventricular fibrillation in Brugada syndrome (2016)
  • Author(s): KUMAGAI, N., OGAWA, M., ZHANG, B., KOYOSHI, R., MORII, J., YASUDA, T., MATSUMOTO, N., MATSUO, K. & SAKU, K.
  • Journal Title: J Cardiol Volume: 67 Issue: 3 Pages: 229-35
  • DOI: 10.1016/j.jjcc.2015.11.002
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Association between pentraxin 3 levels and aortic valve calcification (2016)
  • Author(s): NORIMATSU, K., MIURA, S., SUEMATSU, Y., SHIGA, Y., MIYASE, Y., NAKAMURA, A., ZHANG, B. & SAKU, K.
  • Journal Title: J Cardiol Volume: 68 Issue: 1 Pages: 76-82
  • DOI: 10.1016/j.jjcc.2015.08.010
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Association between dental caries and out-of-hospital cardiac arrests of cardiac origin in Japan (2016)
  • Author(s): SUEMATSU, Y., MIURA, S., ZHANG, B., UEHARA, Y., OGAWA, M., YONEMOTO, N., NONOGI, H., NAGAO, K., KIMURA, T., SAKU, K.
  • Journal Title: J Cardiol Volume: 67 Issue: 4 Pages: 384-91
  • DOI: 10.1016/j.jjcc.2015.06.012
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Stabilization of high-risk plaques (2016)
  • Author(s): TAKATA, K., IMAIZUMI, S., ZHANG, B., MIURA, S. & SAKU, K.
  • Journal Title: Cardiovasc Diagn Ther Volume: 6 Issue: 4 Pages: 304-21
  • DOI: 10.21037/cdt.2015.10.03
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Role of Geminin in cell fate determination of hematopoietic stem cells (HSCs) (2016)
  • Author(s): YASUNAGA, S., OHNO, Y., SHIRASU, N., ZHANG, B., SUZUKI-TAKEDACHI, K., OHTSUBO, M. & TAKIHARA, Y.
  • Journal Title: Int J Hematol Volume: 104 Issue: 3 Pages: 324-9
  • DOI: 10.1007/s12185-016-2060-9
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Stabilization of high-risk plaques (2016)
  • Author(s): Takata K., Imaizumi S., Zhang B., Miura S., Saku K
  • Journal Title: Cardiovasc Diagn Ther Volume: in press Pages: 1-18
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Newly developed apolipoprotein A-I mimetic peptide promotes macrophage reverse cholesterol transport in vivo. (2015)
  • Author(s): Shimizu T, Tanigawa H, Miura S, Kuwano T, Takata K, Suematsu Y, Imaizumi S, Yahiro E, Zhang B, Uehara Y, Saku K.
  • Journal Title: Int J Cardiol. Volume: 192 Pages: 82-88
  • DOI: 10.1016/j.ijcard.2016.01.012
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Associations between different types of hypoglycemic agents and the clinical outcome of percutaneous coronary intervention in diabetic patients-From the FU-Registry (2015)
  • Author(s): Ike A, Shirai K, Nishikawa H, Iwata A, Yahiro E, Sugihara M, Kawamura A, Uehara Y, Zhang B, Ogawa M, Mori K, Miura SI, Saku K
  • Journal Title: J Cardiol Volume: 65 Issue: 5 Pages: 390-396
  • DOI: 10.1016/j.jjcc.2014.06.012
  • Peer Reviewed
• [Journal Article] Selective evaluation of high density lipoprotein from mouse small intestines by an in situ perfusion technique (2014)
  • Author(s): Yamaguchi S, Zhang B, Tomonaga T, Seino U, Kanagawa A, Nagasaka H, Suzuki A, Miida T, Yamada S, Sasaguri Y, Doi T, Saku K, Okazaki M, Tochino Y, Hirano K
  • Journal Title: J Lipid Res Volume: 55 (5) Issue: 5 Pages: 905-18
  • DOI: 10.1194/jlr.m047761
  • Peer Reviewed
• [Journal Article] Impact of cigarette smoking cessation on high-density lipoprotein functionality (2014)
  • Author(s): Takata K, Imaizumi S, Kawachi E, Suematsu Y, Shimizu T, Abe S, Matsuo Y, Tsukahara H, Noda K, Yahiro E, Zhang B, Uehara Y, Miura S, Saku K
  • Journal Title: Circ J Volume: 78 Pages: 2955-2962
  • Peer Reviewed
• [Journal Article] Associations between the consumption of different kinds of seafood and out-of-hospital cardiac arrests of cardiac origin in Japan (2014)
  • Author(s): Suematsu Y, Miura S, Zhang B, Uehara Y, Tokunaga M, Yonemoto N, Nonogi H, Nagao K, Kimura M, Saku K
  • Journal Title: IJC Heart & Vessels Volume: 2 Pages: 8-14
  • DOI: 10.1016/j.ijchv.2013.11.002
  • Peer Reviewed / Open Access
• [Journal Article] Rosuvastatin activates ATP-binding cassette transporter A1-dependent efflux ex vivo and promotes reverse cholesterol transport in macrophage cells in mice fed a high-fat diet (2014)
  • Author(s): Shimizu T, Miura S, Tanigawa H, Kuwano T, Zhang B, Uehara Y, Saku K
  • Journal Title: Arterioscler Thromb Vasc Biol Volume: 34 Issue: 10 Pages: 2246-2253
  • DOI: 10.1161/atvbaha.114.303715
  • Peer Reviewed / Open Access
• [Journal Article] Association of nonsense mutation in GABRG2 with abnormal trafficking of GABA receptors in severe epilepsy (2014)
  • Author(s): Ishii, A., Kanaumi, T., Sohda, M., Misumi, Y., Zhang, B., Kakinuma, N., Haga, Y., Watanabe, K., Takeda, S., Okada, M., Ueno, S., Kaneko, S., Takashima, S., Hirose, S.
  • Journal Title: Epilepsy Res Volume: 108 Issue: 3 Pages: 420-432
  • DOI: 10.1016/j.eplepsyres.2013.12.005
  • Peer Reviewed
• [Journal Article] Early onset and focal spike discharges as indicators of poor prognosis for myoclonic-astatic epilepsy (2014)
  • Author(s): Inoue T, Ihara Y, Tomonoh Y, Nakamura N, Ninomiya S, Fujita T, Ideguchi H, Yasumoto S, Zhang B, Hirose S
  • Journal Title: Brain Dev Volume: 36 Issue: 7 Pages: 613-619
  • DOI: 10.1016/j.braindev.2013.08.009
  • Peer Reviewed
• [Presentation] Effects of CNT-01 on the Production of Lipids and Lipoproteins from the Small Intestine in Mice (2015)
  • Author(s): Zhang B, Yamaguchi S, Hirano H
  • Organizer: The 3rd International Symposium on
  • Place of Presentation: Tokyo, JAPAN
  • Year and Date: 2015-03-14