Diagnostic markers of glandular lesion and their precursor lesions of uterine cervix
Project/Area Number |
26460673
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Laboratory medicine
|
Research Institution | Shinshu University |
Principal Investigator |
OTA Hiroyoshi 信州大学, 学術研究院保健学系, 教授 (50273107)
|
Research Collaborator |
ASAKA Shiho
KUBOTA Seiko
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 胃型腺癌 / 子宮頸部腺系病変 / TFF / 子宮頸部腺癌 / 分葉状子宮頸部腺過形成 / LEGH / 子宮頸部分葉状頸管腺過形成 |
Outline of Final Research Achievements |
In lobular endocervical glandular hyperplasia (LEGH), adenocarcinoma in situ and invasive adenocarcinoma, TFF1 was expressed 100/75/82.5%, TFF2 was expressed 100/37.5/44.8% and GlcNAcα→R recognized by antibody HIK1083 was expressed 100/37.5/44.8%. TFF2 expressed the same localizations with those of GlcNAcα→R. The secretions within the glandular lumens reacted positively for TFF2. TFF2 levels in cervical discharge measured using ELISA were higher in patients with higher scores of latex agglutination test using HIK1083 antibody. Screening of TFFs in cervical discharge may facilitate detection of cervical glandular lesion.
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Report
(4 results)
Research Products
(4 results)
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[Presentation] TFF2 is a useful immunohistochemical marker for gastric type glandular lesion of uterine cervix2017
Author(s)
Shiho Asaka, Nozomi Yazaki, Masayuki Ito, Chinatsu Kobayashi, Tomoyuki Nakajima, Yukihiro kobayashi, Koichi Ida, Keiko Ishi, Takeshi Uehara, Takayuki Honda, and Hiroyoshi Ota
Organizer
第106 回日本病理学会総会
Place of Presentation
京王プラザホテル,東京
Year and Date
2017-04-27
Related Report
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