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Antitumor efficacies of indoleamine 2,3-dioxygenase 2 in lewis lung carcinoma mice model.

Research Project

Project/Area Number 26460675
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Laboratory medicine
Research InstitutionFujita Health University (2016)
Kyoto University (2014-2015)

Principal Investigator

Yamamoto Yasuko  藤田保健衛生大学, 医療科学部, 准教授 (00331869)

Co-Investigator(Renkei-kenkyūsha) SAITO Kuniaki  藤田保健衛生大学, 大学院・医療科学部, 教授 (80262765)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsIDO2 / トリプトファン代謝 / 腫瘍免疫 / 腫瘍 / 細胞増殖
Outline of Final Research Achievements

Indoleamine 2,3-dioxygenase 1 (IDO1) catabolizes tryptophan to kynurenine at the first step of tryptophan metabolism. Recently, in addition to IDO1, a new isoform called IDO2 was identified. The aim of this study was to observe the effect of IDO2 on the growth of transplanted lewis lung carcinoma (LLC) in mice. LLC cells were inoculated subcutaneously into the dorsal of WT (C57BL/6 mice) and IDO2 knock out (IDO2 KO) mice. All mice were sacrificed on day 15, and the tumors were obtained and weighed and the tumor inhibitory rate was calculated. Tumor growth was suppressed in the IDO2 KO mice compared to WT mice. The amount of Trp metabolites in serum of IDO2 KO mice did not changed compared to WT mice. These data suggest that IDO2 control the tumor growth and therapeutic target of cancer.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (7 results)

All 2017 2016

All Journal Article (5 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 5 results,  Acknowledgement Compliant: 4 results,  Open Access: 1 results) Presentation (2 results)

  • [Journal Article] Absence of kynurenine 3-monooxygenase reduces mortality of acute viral myocarditis in mice2017

    • Author(s)
      Kubo H, Hoshi M, Mouri A, Tashita C, Yamamoto Y, Nabeshima T, Saito K.
    • Journal Title

      IMMUNOLOGY LETTERS

      Volume: 181 Pages: 94-100

    • DOI

      10.1016/j.imlet.2016.11.012

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Kynurenine 3-monooxygenase is implicated in antidepressants-responsive depressive-like behaviors and monoaminergic dysfunctions2017

    • Author(s)
      Tashiro T , Murakami Y , Mouri A , Imamura Y, Nabeshima T, Yamamoto, Y , Saito, K
    • Journal Title

      BEHAVIOURAL BRAIN RESEARCH

      Volume: 317 Pages: 279-285

    • DOI

      10.1016/j.bbr.2016.09.050

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Effect of water-immersion restraint stress on tryptophan catabolism through the kynurenine pathway in rat tissues2017

    • Author(s)
      Ohta, Y ; Kubo, H ; Yashiro, K ; Ohashi, K ; Tsuzuki, Y ; Wada, N ; Yamamoto, Y ; Saito, K
    • Journal Title

      JOURNAL OF PHYSIOLOGICAL SCIENCES 4.巻 67 5.発行年 2017

      Volume: 4 Pages: 361-372

    • NAID

      40021176369

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Depressive symptoms as a side effect of Interferon-α therapy induced by induction of indoleamine 2,3-dioxygenase 1.2016

    • Author(s)
      Murakami Y, Ishibashi T, Tomita E, Imamura Y, Tashiro T, Watcharanurak K, Nishikawa M, Takahashi Y, Takakura Y, Mitani S, Fujigaki H, Ohta Y, Kubo H, Mamiya T, Nabeshima T, Kim HC, Yamamoto Y, Saito K.
    • Journal Title

      SCIENTIFIC REPORTS

      Volume: 6 Issue: 1 Pages: 29920-29920

    • DOI

      10.1038/srep29920

    • NAID

      120006323748

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] L-Tryptophan-kynurenine pathway enzymes are therapeutic target for neuropsychiatric diseases: Focus on cell type differences.2016

    • Author(s)
      Fujigaki H, Yamamoto Y, Saito K
    • Journal Title

      Neuropharmacology.

      Volume: 印刷中 Pages: 264-274

    • DOI

      10.1016/j.neuropharm.2016.01.011

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 周産期における抑うつにおけるトリプトファン代謝関連分子の変化2016

    • Author(s)
      勅使河原知明、久保緋紗子、毛利彰宏、鍋島俊隆、尾崎紀夫、山本康子、齋藤邦明
    • Organizer
      第56回日本臨床化学会学術大会
    • Place of Presentation
      熊本県民交流館パレア(熊本)
    • Related Report
      2016 Annual Research Report
  • [Presentation] Absence of kynurenine 3-monooxygebase reduces mortality of accute viral myocarditis in mice2016

    • Author(s)
      久保緋紗子、星雅人、毛利彰宏、田下智栄子、勅使河原知明、山菅和可菜、和田直也、山本康子、鍋島俊隆、毛利彰宏
    • Organizer
      第37回日本トリプトファン研究開学術集会
    • Place of Presentation
      東京農業大学
    • Related Report
      2016 Annual Research Report

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Published: 2014-04-04   Modified: 2018-03-22  

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