Analysis of altered hematopoietic niche mechanisms mediated by transcriptional coregulator complex Mediator

• Project/Area Number: 26460677
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Laboratory medicine
• Research Institution: Kobe University
• Principal Investigator: Ito Mitsuhiro 神戸大学, 保健学研究科, 教授 (50362794)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 転写メディエーター / MED1 / 造血ニッチ / 間葉系間質細胞 / ぺリオスチン / 転写調節 / 生体分子 / 生理活性 / 内科 / 発現制御 / メディエーター / 造血微小環境 / 骨髄間質細胞

Outline of Final Research Achievements

Both normal and leukemic blood cells are produced and proliferate in the bone marrow, and these processes are now known to be supported by various soluble factors produced by the mesenchymal stromal cells. We have found that the MED1 subunit of master transcriptional coregulatory complex Mediator at least partially employs these processes through regulating production of a variety of soluble factors, and that periostin under the transcriptional control of MED1 supports normal and malignant blood cell production in these processes. Periostin is produced by the mesenchymal stromal cells, and the production is enhanced by a direct contact with blood cells. Periostin acts on mesenchymal stromal cells themselves, and probably also directly on blood cells, through its cognate receptor integrin αvβ3.

Research Products

• [Int'l Joint Research] The Rockefeller University(米国)
• [Int'l Joint Research] Rockefeller University(米国)
• [Journal Article] Periostin supports hematopoietic progenitor cells and niche-dependent myeloblastoma cells in vitro. (2016)
  • Author(s): Tanaka S, Maekawa A, Matsubara L, Imanishi A, Yano M, Roeder RG, Hasegawa N, Asano S, Ito M
  • Journal Title: Biochem. Biophys. Res. Commun. Volume: 478 Issue: 4 Pages: 1706-1712
  • DOI: 10.1016/j.bbrc.2016.09.008
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] The Mediator Subunit MED16 Transduces NRF2-Activating Signals into Antioxidant Gene Expression. (2016)
  • Author(s): Sekine H, Okazaki K, Ota N, Shima H, Katoh Y, Suzuki N, Igarashi K, Ito M, Motohashi H, Yamamoto M
  • Journal Title: Mol Cell Biol Volume: 36 Issue: 3 Pages: 407-420
  • DOI: 10.1128/mcb.00785-15
  • Peer Reviewed / Open Access
• [Journal Article] A prospective study on the efficacy of two-dose influenza vaccinations in cancer patients receiving chemotherapy. (2016)
  • Author(s): Sanada Y, Yakushijin K, Nomura T, Chayahara N, Toyoda M, Minami Y, Kiyota N, Mukohara T, Kawamoto S, Ito M, Matsuoka H, Minami H
  • Journal Title: Jpn. J. Clin. Oncol. Volume: 46 Issue: 5 Pages: 448-452
  • DOI: 10.1093/jjco/hyw020
  • Peer Reviewed
• [Journal Article] A prospective study of the antiemetic effect of palonosetron in malignant lymphoma patients treated with the CHOP regimen. (2016)
  • Author(s): Miyata Y, Yakushijin K, Inui Y, Imamura Y, Goto H, Mizutani Y, Kurata K, Kakiuchi S, Sanada Y, Minami Y, Kawamoto S, Yamamoto K, Ito M, Tominaga R, Gomyo H, Mizuno I, Nomura T, Kitagawa K, Sugimoto T, Murayama T, Matsuoka H, Minami H.
  • Journal Title: Int J Hematol Volume: 104 Issue: 6 Pages: 682-691
  • DOI: 10.1007/s12185-016-2089-9
  • Peer Reviewed
• [Journal Article] A prospective study on the efficacy of two-dose influenza vaccinations in cancer patients receiving chemotherapy. (2016)
  • Author(s): Sanada Y, Yakushijin K, Nomura T, Chayahara N, Toyoda M, Minami Y, Kiyota N, Mukohara T, Kawamoto S, Ito M, Matsuoka H, Minami H
  • Journal Title: Jpn J Clin Oncol Volume: in press
  • Peer Reviewed
• [Journal Article] Methotrexate-associated lymphoproliferative disorders: management by watchful waiting and observation of early lymphocyte recovery after methotrexate withdrawal. (2015)
  • Author(s): Inui Y, Matsuoka H, Yakushijin K, Okamura A, Shimada T, Yano S, Takeuchi M, Ito M, Murayama T, Yamamoto K, Itoh T, Aiba K, Minami H
  • Journal Title: Leuk Lymphoma Volume: 56 Issue: 11 Pages: 3045-3051
  • DOI: 10.3109/10428194.2015.1022769
  • Peer Reviewed
• [Journal Article] Rhabdomyolysis Caused by <i>Candida parapsilosis</i> in a Patient with Acute Myeloid Leukemia after Bone Marrow Transplantation (2015)
  • Author(s): Kakiuchi S, Yakushijin K, Yamamoto K, Tomioka H, Inui Y, Okamura A, Kawamoto S, Minami Y, Murayama T, Ito M, Matsuoka H, Minami H
  • Journal Title: Internal Medicine Volume: 54 Issue: 16 Pages: 2057-2060
  • DOI: 10.2169/internalmedicine.54.4136
  • NAID: 130005092915
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed / Open Access
• [Journal Article] A case of CD10-negative angioimmunoblastic T cell lymphoma with leukemic change and increased plasma cells mimicking plasma cell leukemia: A case report. (2015)
  • Author(s): Adachi Y, Hino T, Ohsawa M, Ueki K, Murao T, Li M, Cui Y, Okigaki M, Ito M, Ikehara S
  • Journal Title: Oncol Lett Volume: 10 Pages: 1555-1560
  • Peer Reviewed / Open Access
• [Journal Article] Methotrexate-associated lymphoproliferative disorders: management by watchful waiting and observation of early lymphocyte recovery after methotrexate withdrawal (2015)
  • Author(s): Y. Inui, H. Matsuoka, K. Yakushijin, A. Okamura, T. Shimada, S. Yano, M. Takeuchi, M. Ito, T. Murayama, K. Yamamoto, T. Itoh, K. Aiba, H. Minami
  • Journal Title: Leuk. Lymphoma Volume: 未定
  • Peer Reviewed / Open Access
• [Journal Article] Rhabdomyolysis caused by Candida parapsilosis in a patient with acute myeloid leukemia after bone marrow transplantation (2015)
  • Author(s): S. Kakiuchi, K. Yakushijin, K. Yamamoto, H. Tomioka, Y. Inui, A. Okamura, S. Kawamoto, Y. Minami, T. Murayama, M. Ito, H. Matsuoka, H. Minami
  • Journal Title: Intern. Med. Volume: 未定
  • NAID: 130005092915
  • Peer Reviewed / Open Access
• [Journal Article] CCAR1/CoCoA pair-mediated recruitment of the Mediator defines a novel pathway for GATA1 function. (2014)
  • Author(s): Mizuta S, Minami T, Fujita H, Kaminaga C, Matsui K, Ishino R, Fujita A, Oda K, Kawai A, Hasegawa N, Urahama N, Roeder RG, Ito M
  • Journal Title: Genes to cells Volume: 19 Issue: 1 Pages: 28-51
  • DOI: 10.1111/gtc.12104
  • Peer Reviewed / Open Access
• [Journal Article] Benefits of skin biopsy of senile hemangioma in intravascular large B cell lymphoma: A case report and review of the literature (2014)
  • Author(s): Yasushi Adachi, Mitsuki Kosami, Noritoshi Mizuta, Mitsuhiro Ito, Yuki Matsuoka, Mami Kanata, Hajime Akiyama, Tomoko Murao, Ming Li, Ryuuji Ieki, Susumu Ikehara
  • Journal Title: Oncology Lett. Volume: 7 Pages: 2003-2006
  • Peer Reviewed / Open Access
• [Presentation] 難治性の口唇慢性GVHDに対して湿潤療法が著効した一例 (2017)
  • Author(s): 市川大哉、奥野真紀子、坂井里奈、水谷優、倉田啓史、須藤洋崇、垣内誠司、北尾章人、宮田吉晴、眞田幸尚、乾由美子、瓜生恭章、斉藤泰之、藥師神公和、川本晋一郎、田村恵利、岸本恵美、伊藤光宏、松岡広、南博信
  • Organizer: 第39回日本造血細胞移植学会総会
  • Place of Presentation: 松江、くにびきメッセ、嶋根県民会館
  • Year and Date: 2017-03-02
• [Presentation] Periostin Supports Hematopoietic Stem/progenitor Cells and Niche-dependent Myeloblastoma Cells in vitro (2016)
  • Author(s): Akio Maekawa, Natsumi Hasegawa, Satowa Tanaka, Leo Matsubara, Azusa Imanishi, Masaya Yano, Robert G. Roeder, Shigetaka Asano, Mitsuhiro Ito
  • Organizer: 58th Annual Meeting of the American Society of Hematology
  • Place of Presentation: San Diego, San Diego Convention Center, CA, USA
  • Year and Date: 2016-12-03
  • Int'l Joint Research
• [Presentation] 乳癌の発症と進展におけるMED1の役割 (2016)
  • Author(s): 峰松侑希、長谷川菜摘、井之上菜名子、前川茜、福岡知也、越谷愛里、Robert G. Roeder、伊藤光宏
  • Organizer: 第39回日本分子生物学会年会
  • Place of Presentation: 横浜、パシフィコ横浜
  • Year and Date: 2016-11-30
• [Presentation] PPARγ結合能廃絶MED1を持つ変異マウスの骨格筋 (2016)
  • Author(s): 﨑洋樹、物延沙耶、前川茜、安達枝里、髙原拓、森真洋、Robert G. Roeder、長谷川菜摘、伊藤光宏
  • Organizer: 第39回日本分子生物学会年会
  • Place of Presentation: 横浜、パシフィコ横浜
  • Year and Date: 2016-11-30
• [Presentation] MED1-dependent and -independent coactivation mechanism of Mediator for GATA1 action. (2016)
  • Author(s): Mahiro Mori, Asami Kawai, Taku Takahara, Tomoya Fukuoka, Eri Koshitani, Akane Maekawa, Hiroki Nagasaki, Nanako Inoue, Saya Mononobe, Yuki Minematsu, Eri Adachi, Natsumi Hasegawa, Mitsuhiro Ito
  • Organizer: 第78回日本血液学会学術集会
  • Place of Presentation: 横浜、パシフィコ横浜
  • Year and Date: 2016-10-13
• [Presentation] RAR-binding ability of MED1 is required for high-concentration ATRA-dependent activation of PML-RARα. (2016)
  • Author(s): Taku Takahara, Asami Kawai, Mahiro Mori, Eri Koshitani, Tomoya Fukuoka, Nanako Inoue, Akane Maekawa, Hiroki Nagasaki, Yuki Minematsu, Saya Mononobe, Natsumi Hasegawa, Mitsuhiro Ito
  • Organizer: 第78回日本血液学会学術集会
  • Place of Presentation: 横浜、パシフィコ横浜
  • Year and Date: 2016-10-13
• [Presentation] Periostin supports hematopoietic stem/progenitor cells and niche-dependent myeloblastoma cells (2016)
  • Author(s): Akio Maekawa, Satowa Tanaka, Leo Matsubara, Masaya Yano, Azusa Imanishi, Aya Yokoi, Chie Goto, Takako Fukunaga, Natsumi Hasegawa, Shigetaka Asano, Mitsuhiro Ito
  • Organizer: 第78回日本血液学会学術集会
  • Place of Presentation: 横浜、パシフィコ横浜
  • Year and Date: 2016-10-13
• [Presentation] BRAF V600E mutation-specific antibody for the diagnosis of hairy cell leukemia (2016)
  • Author(s): Akihito Kitao, Kimikazu Yakushijin, Eriko Honda, Hiroya Ichikawa, Yu Mizutami, Yoshiharu Miyata, Kimiaki Uryu, Yumiko Inui, Shinichiro Kawamoto, Hiroshi Matsuoka, Mitsuhiro Ito, Tomoo Itoh, Hironobu Minami
  • Organizer: 第78回日本血液学会学術集会
  • Place of Presentation: 横浜、パシフィコ横浜
  • Year and Date: 2016-10-13
• [Presentation] The antiemetic effect of palonosetron in malignant lymphoma patients treated with the CHOP regimen (2016)
  • Author(s): Y. Miyata, K. Yakushijin, Y. Inui, Y. Imamura, H. Goto, Y. Mizutani, K. Kurata, S. Kakiuchi, Y. Sanada, Y. Minami, S. Kawamoto, Mi. Ito, R. Tominaga, H. Gomyo, I. Mizuno, T. Nomura, K. Kitagawa, T. Sugimoto, T. Murayama, H. Matsuoka, H. Minami
  • Organizer: 第78回日本血液学会学術集会
  • Place of Presentation: 横浜、パシフィコ横浜
  • Year and Date: 2016-10-13
• [Presentation] 同種造血幹細胞移植後のリンパ球回復と予後に関する後方視的解析 (2016)
  • Author(s): 倉田 啓史、薬師神 公和、乾 由美子、岡村 篤夫、川本 晋一郎、南 陽介、山本 克也、伊藤 光宏、松岡 宏、南 博信
  • Organizer: 第14回日本臨床腫瘍学会学術集会
  • Place of Presentation: 神戸、神戸国際会議場・展示場
  • Year and Date: 2016-07-28
• [Presentation] Delayed absolute lymphocyte count recovery after allogeneic hematopoietic stem cell transplantation with mycophenolate mofetil. (2016)
  • Author(s): Keiji Kurata, Kimikazu Yakushijin, Ishikazu Mizuno, Yumiko Inui, Hiroshi Gomyo, Atsuo Okamura, Ryo Tominaga, Shinichiro Kawamoto, Yosuke Minami, Akio Maeda, Katsuya Yamamoto, Tohru Murayama, Mitsuhiro Ito, Hiroshi Matsuoka, Hironobu Minami
  • Organizer: 7th Japanese Society of Hematology (JSH) International Symposium
  • Place of Presentation: Awaji, Hyogo, Japan
  • Year and Date: 2016-05-13
  • Int'l Joint Research
• [Presentation] Delayed absolute lymphocyte count recovery after allogeneic hematopoietic stem cell transplantation with mycophenolate mofetil. (2016)
  • Author(s): Keiji Kurata, Kimikazu Yakushijin, Ishikazu Mizuno, Yumiko Inui, Hiroshi Gomyo, Atsuo Okamura, Ryo Tominaga, Shinichiro Kawamoto, Yosuke Minami, Akio Maeda, Katsuya Yamamoto, Tohru Murayama, Mitsuhiro Ito, Hiroshi Matsuoka, Hironobu Minami
  • Organizer: 7th Japanese Society of Hematology (JSH) International Symposium
  • Place of Presentation: Awaji, Japan
  • Year and Date: 2016-05-13
  • Int'l Joint Research
• [Presentation] Absolute lymphocyte count recovery predicts clinical outcome after allogeneic hematopoietic stem cell transplantation in a Japanese population. (2016)
  • Author(s): Keiji Kurata, Kimikazu Yakushijin, Ishikazu Mizuno, Yumiko Inui, Atsuo Okamura, Hiroya Ichikawa, Yu Mizutani, Seiji Kakiuchi, Yoshiharu Miyata, Akihito Kitao, Yasuyuki Saito, Yosuke Minami, Shinichiro Kawamoto, Katsuya Yamamoto, Toru Mukohara, Mitsuhito Ito, Hiroshi Matsuoka, Hiromobu Minami
  • Organizer: 42nd Annual Meeting of the European Society for Blood and Marrow Transplantation (EBMT2016)
  • Place of Presentation: Valencia, Spain
  • Year and Date: 2016-04-03
  • Int'l Joint Research
• [Presentation] 自律神経ストームを伴った造血幹細胞移植後HHV-6脳炎 (2016)
  • Author(s): 乾由美子、薬師神公和、水谷優、市川大哉、倉田啓史、垣内誠司、宮田吉晴、真田幸尚、北尾章人、南陽介、岡村篤夫、川本晋一郎、田中康博、新里偉咲、山本克也、村山徹、伊藤光宏、松岡広、南博信
  • Organizer: 第38回日本造血細胞移植学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2016-03-03
• [Presentation] 自家移植後の再発・骨髄不全に対し、同種骨髄移植が有効であった原発性マクログロブリン血症 (2016)
  • Author(s): 水谷優、北尾章人、乾由美子、瓜生泰章、薬師神公和、服部貴之、本多瑛理子、市川大哉、倉田啓史、垣内誠司、宮田吉晴、真田幸尚、川本晋一郎、南陽介、伊藤智雄、伊藤光宏、松岡広、南博信
  • Organizer: 第38回日本造血細胞移植学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2016-03-03
• [Presentation] Periostin supports normal and malignant hematopoietic stem/progenitor cells in vitro. (2015)
  • Author(s): Akio Maekawa, Satowa Tanaka, Azusa Imanishi, Masaya Yano, Leo Matsubara, Natsumi Hasegawa, Shigetaka Asano, Mitsuhiro Ito
  • Organizer: 第38回日本分子生物学会年会第88回日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2015-12-01
• [Presentation] Mediator subunit MED1 is required for PML-RARα fusion protein-induced transcriptional activation in response high concentration all-trans retinoic acid. (2015)
  • Author(s): Taku Takahara, Asami Kawai, Mahiro Mori, Gentaro Tango, Yusuke Takemoto, Akane Maekawa, Norinaga Urahama, Natsumi Hasegawa, Mitsuhiro Ito
  • Organizer: 第38回日本分子生物学会年会第88回日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2015-12-01
• [Presentation] GATA1による転写活性化におけるMED1依存性と非依存性の機序 (2015)
  • Author(s): 森真洋、河合麻美、水田駿平、高原拓、丹後元太郎、矢野雅也、Robert G. Roeder、長谷川菜摘、伊藤光宏
  • Organizer: 第38回日本分子生物学会年会第88回日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2015-12-01
• [Presentation] 乳癌発症が遺伝要因と環境要因に依存する可能性&#8722;乳癌モデルマウスの検討 (2015)
  • Author(s): 井之上菜名子、長谷川菜摘、神田織江、峰松侑希、武元優允、丹後元太郎、前川茜、長崎洋樹、今西梓、伊藤光宏
  • Organizer: 第38回日本分子生物学会年会第88回日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2015-12-01
• [Presentation] MED1結合蛋白CCAR1とCoCoAはPPARγ2誘導性の白色脂肪細胞分化を司る (2015)
  • Author(s): 武元優允、松井啓治、前川茜、長崎洋樹、井之上菜名子、物延沙耶、今西梓、長谷川菜摘、Robert G. Roeder、伊藤光宏
  • Organizer: 第38回日本分子生物学会年会第88回日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2015-12-01
• [Presentation] 骨髄間質細胞が産生するオステオポンチンは造血幹・前駆細胞をCD44を介して支持する (2015)
  • Author(s): 矢野雅也、今西梓、松原怜央、前川晶保、田中里和、長崎洋樹、河合麻美、長谷川菜摘、浅野茂隆、伊藤光宏
  • Organizer: 第38回日本分子生物学会年会第88回日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2015-12-01
• [Presentation] High-concentration ATRA-dependent activation of PML-RARα requires Mediator subunit MED1. (2015)
  • Author(s): Asami Kawai, Taku Takahara, Mahiro Mori, Gentaro Tango, Yusuke Takemoto, Orie Kanda, Natsumi Hasegawa, Mitsuhiro Ito.
  • Organizer: 第77回日本血液学会学術集会
  • Place of Presentation: 金沢
  • Year and Date: 2015-10-26
• [Presentation] Periostin supports hematopoietic stem/progenitor cells and niche-dependent myeloblastoma cells. (2015)
  • Author(s): Satowa Tanaka, Akio Maekawa, Masaya Yano, Azusa Imanishi, Natsumi Hasegawa, Yoichi Nakao, Shigetaka Asano, Mitsuhiro Ito
  • Organizer: 第77回日本血液学会学術集会
  • Place of Presentation: 金沢
  • Year and Date: 2015-10-26
• [Presentation] 急性前骨髄球性白血病とその他の急性骨髄性白血病の鑑別診断におけるmyeloperoxidase indexの有用性 (2015)
  • Author(s): 米澤賢二、大本知佳、水田あずさ、天神貴子、八木智恵、升村京子、足立綾、三村喜彦、富永亮、五明広志、前田彰男、水野石一、村山徹、伊藤光宏
  • Organizer: 第77回日本血液学会学術集会
  • Place of Presentation: 金沢
  • Year and Date: 2015-10-26
• [Presentation] Absolute lymphocyte count recovery predicts clinical outcomes after allogeneic hematopoietic stem cell transplantation. (2015)
  • Author(s): Keiji Kurata, Kimikazu Yakushijin, Atsuo Okamura, Yukinari Sanada, Hideaki Goto, Yu Mizutani, Seiji Kakiuchi, Yoshiharu Miyata, Yumiko Inui, Yohei Funakoshi, Kiyoaki Uryu, Shinichiro Kawamoto, Yosuke Minami Katsuya Yamamoto, Tohru Murayama, Mitsuhiro Ito, Hiroshi Matsuoka, and Hironobu Minami
  • Organizer: The 6th JSH International Symposium 2015
  • Place of Presentation: Karuizawa, Japan
  • Year and Date: 2015-05-22
  • Int'l Joint Research
• [Presentation] Periostin supports normal and malignant hematopoietic stem/progenitor cells in vitro. (2015)
  • Author(s): Satowa Tanaka, Akio Maekawa, Masaya Yano, Azusa Imanishi, Natsumi Hasegawa, Yoichi Nakao, Shigetaka Asano, Mitsuhiro Ito
  • Organizer: International Conference on The Tumour Microenvironment in the Haematological Malignancies and its Therapeutic Targeting, European School of Haematology
  • Place of Presentation: Lisbon, Portugal
  • Year and Date: 2015-05-07
  • Int'l Joint Research
• [Presentation] Relationship to Tissue-specific Stem Cells. (2015)
  • Author(s): Mitsuhiro Ito
  • Organizer: AsiaCORD/AHA2015 “Toward an Asian MSC Hybrid Banking System”
  • Place of Presentation: Kobe, Japan
  • Year and Date: 2015-05-01
  • Int'l Joint Research / Invited
• [Presentation] Manner of recruitment of GATA1 coactivators to γ-globin promoter during erythroid differentiation (2014)
  • Author(s): Asami Kawai, Haruka Fujita, Shumpei Mizuta, Orie Kanda, Yusuke Takemoto, Gentaro Tango, Taku Takahara, Mahiro Mori, Natsumi Hasegawa, Mitsuhiro Ito
  • Organizer: 第37回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜（横浜市）
  • Year and Date: 2014-11-25 – 2014-11-27
• [Presentation] FGF7 produced by BM stromal cells supports hematopoietic progenitor cells in an autocrine manner (2014)
  • Author(s): Satowa Tanaka, Ruri Ishino, Masaya Yano, Azusa Imanishi, Akio Maekawa, Kenji Yonezawa, Natsumi Hasegawa, Shigetaka Asano, Mitsuhiro Ito
  • Organizer: 第37回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜（横浜市）
  • Year and Date: 2014-11-25 – 2014-11-27
• [Presentation] FGF7 elicits maintenance and growth of stromal cell-dependent human MB-1 myeloblastoma cells (2014)
  • Author(s): Azusa Imanishi, Satowa Tanaka, Ruri Ishino, Masaya Yano, Mami Nagai, Akio Maekawa, Natsumi Hasegawa, Shigetaka Asano, Mitsuhiro Ito
  • Organizer: 第37回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜（横浜市）
  • Year and Date: 2014-11-25 – 2014-11-27
• [Presentation] Mechanistic analysis of MED1-dependent function of VDR and Runx2 on the Osteopontin promoter (2014)
  • Author(s): Masaya Yano, Ruri Ishino, Akiko Sumitomo, Kana Inoue, Norinaga Urahama, Azusa Imanishi, Satowa Tanaka, Akio Maekawa, Natsumi Hasegawa, Shigetaka Asano, Mitsuhiro Ito
  • Organizer: 第37回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜（横浜市）
  • Year and Date: 2014-11-25 – 2014-11-27
• [Presentation] Role for Mediator subunit MED1 in homeostasis of TSHβ gene transcription (2014)
  • Author(s): Natsumi Hasegawa, Keiji Matsui, Kasumi Oda, Shumpei Mizuta, Ruri Ishino, Asami Kawai, Norinaga Urahama, Robert G. Roeder, Mitsuhiro Ito
  • Organizer: 第37回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜（横浜市）
  • Year and Date: 2014-11-25 – 2014-11-27
• [Presentation] FGF7 supports maintenance and growth of stromal cell-dependent growth of human myeloblastoma MB-1 cells (2014)
  • Author(s): Satowa Tanaka, Ruri Ishino, Mami Nagai, Masaya Yano, Azusa Imanishi, Gentaro Tango, Akio Maekawa, Natsumi Hasegawa, Shigetaka Asano, Mitsuhiro Ito
  • Organizer: 第76回日本血液学会総会
  • Place of Presentation: 大阪国際会議場（大阪市）
  • Year and Date: 2014-10-31 – 2014-11-02
• [Presentation] Manner of recruitment of GATA1 coactivators to γ-globin promoter during erythroid differentiation (2014)
  • Author(s): Asami Kawai, Haruka Fujita, Shumpei Mizuta, Orie Kanda, Yusuke Takemoto, Gentaro Tango, Taku Takahara, Mahiro Mori, Natsumi Hasegawa, Mitsuhiro Ito
  • Organizer: 第76回日本血液学会総会
  • Place of Presentation: 大阪国際会議場（大阪市）
  • Year and Date: 2014-10-31 – 2014-11-02
• [Presentation] Role of proteinase inhibitor 9 and granzyme B in peripheral regulatory T cells (2014)
  • Author(s): Osamu Horie, Tomoko Okamoto, Kaori Minami, Hiromi Shibata, Tohru Murayama, Mitsuhiro Ito
  • Organizer: 第76回日本血液学会総会
  • Place of Presentation: 大阪国際会議場（大阪市）
  • Year and Date: 2014-10-31 – 2014-11-02
• [Presentation] Rapid recovery of lymphocyte counts after stopping MTX treatment might predict following regression of MTX-LPD (2014)
  • Author(s): Yumiko Inui, Hiroshi Matsuoka, Takashi Shimada, Kimikazu Yakushijin, Atsuo Okamura, Mitsuhiro Ito, Tomoo Ito, Yukinari Sanada, Yoshiharu Miyata, Seiji Kakiuchi, Yuriko Kawamori, Shingo Yano, Yuichi Yahagi, Katsuki Sugiyama, Yoji Ogasawara, Shinobu Takahara, Takeshi Saito, Katsuya Yamamoto, Keisuke Aiba, Hironobu Minami
  • Organizer: 第76回日本血液学会総会
  • Place of Presentation: 大阪国際会議場（大阪市）
  • Year and Date: 2014-10-31 – 2014-11-02
• [Presentation] 急性前骨髄球性白血病（APL）の診断における平均好中球ミエロペルオキシダーゼ活性指数（MPXI）の有用性 (2014)
  • Author(s): 米澤賢二、大本知佳、藤田あずさ、足立綾、山内由里子、富永亮、五明広志、前田彰男、水田一石、村山徹、伊藤光宏
  • Organizer: 第76回日本血液学会総会
  • Place of Presentation: 大阪国際会議場（大阪市）
  • Year and Date: 2014-10-31 – 2014-11-02
• [Presentation] FGF7 supports hematopoietic stem/progenitor cells and niche-dependent myeloblastoma cells via autocrine action on bone marrow stromal cells (2014)
  • Author(s): Satowa Tanaka, Ruri Ishino, Azusa Imanishi, Masaya Yano, Keiji Matsui, Kaori Minami, Mami Nagai, Natsumi Hasegawa, Shigetaka Asano, Mitsuhiro Ito
  • Organizer: The 12th Stem Cell Research Symposium
  • Place of Presentation: 九州大学（福岡市）
  • Year and Date: 2014-05-30 – 2014-05-31
• [Remarks] http://www2.kobe-u.ac.jp/~itomi/
• [Remarks]
  • URL: http://www2.kobe-u.ac.jp/~itomi/
• [Remarks]
  • URL: http://www2.kobe-u.ac.jp/~itomi/