| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Outline of Final Research Achievements |
Both normal and leukemic blood cells are produced and proliferate in the bone marrow, and these processes are now known to be supported by various soluble factors produced by the mesenchymal stromal cells. We have found that the MED1 subunit of master transcriptional coregulatory complex Mediator at least partially employs these processes through regulating production of a variety of soluble factors, and that periostin under the transcriptional control of MED1 supports normal and malignant blood cell production in these processes. Periostin is produced by the mesenchymal stromal cells, and the production is enhanced by a direct contact with blood cells. Periostin acts on mesenchymal stromal cells themselves, and probably also directly on blood cells, through its cognate receptor integrin αvβ3.
|
