Analysis of the immune response of platelet activation and macrophages by H. pylori membrane proteins
| Project/Area Number |
26460680
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Kochi University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
西田 愛恵 高知大学, 医学部附属病院, 臨床検査技師 (30600796)
杉浦 哲朗 高知大学, 医学部附属病院, 特任教授 (50171145)
竹内 啓晃 高知大学, 教育研究部医療学系臨床医学部門, 講師 (90346560)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | Helicobacter pylori / 免疫性血小板減少症 / H, pylori 膜蛋白 / 血小板 / H. pylori膜蛋白 / マクロファージ / 膜蛋白 / cTP |
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| Outline of Final Research Achievements |
Helicobacter pylori infection has been assocoated in the pathogenesis of immune thrombocytopenic purpura (ITP). We reported the possibility that the immunocomplexes consisting of H. pylori outer membrane (Hp-OMP) , platelet and anti Hp-OMP antibodies were involved in development of H.pylori associated ITP as an extra mechanism.Patients with ITP were classified into 3 groups: H. pylori - negative (Hp-N); H. pylori - positive and completely or partially responsive to treatment (CR); H. pylori - positive and irresponsive to treatment (NR). Reactivity of antibodies to Hp-OMP was examined by ELISA. Value of anti-Hp-OMP antibody by ELISA, Hp-OMP was significant higher in infected groups (CR and NR) than that in Hp-N. Its value was higher in CR than that in NR. Phagocytosis of the immunocomplexes were not detected by microscopic and immunoblot analysis.
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Report
(4 results)
Research Products
(13 results)
