Induction and Enhancement of Iodide Transporter Expression in Gastric Cancer Cells
| Project/Area Number |
26460684
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Dokkyo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
菱沼 昭 獨協医科大学, 医学部, 教授 (40201727)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | ヨードトランスポーター / レチノイド / 胃癌 / レチノイン酸 / ナトリウム/ヨード共輸送体 / 遺伝子発現誘導 / 胃癌細胞株 / 放射性ヨード治療 / ナトリウム・ヨード共輸送体 / 胃癌細胞 / 蛋白質合成阻害剤 / ヨード・トランスポーター / AKT阻害剤 |
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| Outline of Final Research Achievements |
The iodide transporter, NIS, is abundantly expressed in thyroid, as well as breast cancer and gastric cancer. Tumor-specific enhancement of its expression would make it possible to apply radio-iodide to target the tumors. We found significant induction of NIS expression by RXR agonists, and its enhancement by AKT inhibitors, in an in vitro model of gastric cancer. A number of translation inhibitors also induced the NIS expression in several cancer cell lines. Comprehensive analysis of miRNA expression in those cells suggested some miRNAs as potential NIS stimulators.
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Report
(5 results)
Research Products
(21 results)
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[Journal Article] A Novel Germline Mutation of KEAP1 (R483H) Associated with a Non-Toxic Multinodular Goiter2016
Author(s)
Nishihara E, Hishinuma A, Kogai T, Takada N, Hirokawa M, Fukata S, Ito M, Yabuta T, Nishikawa M, Nakamura H, Amino N, Miyauchi A
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Journal Title
Front Endocrinol
Volume: 7
Pages: 131-131
DOI
Related Report
Peer Reviewed / Open Access
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