Role of PU.1 suppressive target gene, metallothionein, as a forecasting biomarker for anticancer agents
Project/Area Number |
26460685
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Laboratory medicine
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Research Institution | Tohoku Medical and Pharmaceutical University (2016-2017) Kitasato University (2014-2015) |
Principal Investigator |
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Project Period (FY) |
2014-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | メタロチオネイン / 抗がん剤 / 効果予測マーカー |
Outline of Final Research Achievements |
We previously identified a multifunctional factor, metallothionein (MT), as a myeloid master transcription factor PU.1 suppressive target gene. We previously revealed that MT strongly suppresses all-trans retinoid acid induced acute promyelocytic leukemia (NB4) cells differentiation. In this study, we revealed that MT not only inhibits myeloid cell differentiation, but also bears activity for drug resistance, especially for cytarabine (Ara-C). We revealed that the MT over-expressed NB4 cells bears 1.5 to 2.0 times higher ED50 doses of Ara-C compared to their controls.
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Report
(5 results)
Research Products
(26 results)
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[Journal Article] Metallothionein-1 as a biomarker of altered redox metabolism in hepatocellular carcinoma cells exposed to sorafenib2016
Author(s)
Houessinon A, François C, Sauzay C, Louandre C, Mongelard G, Godin C, Bodeau S, Takahashi S, Saidak Z, Gutierrez L, Régimbeau JM, Barget N, Barbare JC, Ganne N, Chauffert B, Coriat R, Galmiche A
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Journal Title
Mol Cancer
Volume: 15
Issue: 1
Pages: 38-38
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] Detection of Anti-Thrombopoietin antibodies in patients with immune thrombocytopenia2014
Author(s)
Satoh T, Miyazaki T, Osawa E, Modegi N, Kita A, Kurihara S, Kawasaki Y, Shimada N, Nagane K, Higashihara M, Takahashi S
Organizer
American Society of Hematology Meeting
Place of Presentation
San Diego Convention Center, San Diego, USA
Year and Date
2014-12-08
Related Report
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[Presentation] Analysis of anti-thrombopoietin antibody in patients with immune thrombocytopenia2014
Author(s)
Satoh T, Miyazaki K, Shimada N, Nagane K, Kita A, Kurihara S, Kawasaki Y, Kodaira Y, Osawa E, Modegi N, Higashihara M, Takahashi S
Organizer
日本血液学会
Place of Presentation
大阪国際会議場(大阪府大阪市)
Year and Date
2014-11-02
Related Report
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[Presentation] Detection of anti-thrombopoietin autoantibody among immune thrombocytopenic patients2014
Author(s)
Miyazaki T, Satoh T, Osawa E, Modegi N, Kita A, Kurihara S, Kawasaki Y, Shimada N, Nagane K, Higashihara M, Takahashi S
Organizer
19th Congress of European Hematology Association Meeting
Place of Presentation
Milano Congressi, Milan, Italy
Year and Date
2014-06-13
Related Report
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