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Cancer diagnosis by analysis of circulating tumor cells with high telomerase activity and cell-free DNA

Research Project

Project/Area Number 26460688
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Laboratory medicine
Research InstitutionShowa University

Principal Investigator

Ito Hiroaki  昭和大学, 医学部, 准教授 (70443447)

Co-Investigator(Renkei-kenkyūsha) Haruhiro Inoue  昭和大学, 医学部, 教授 (90280966)
Satoshi Kimura  昭和大学, 医学部, 教授 (30255765)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2015: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsがん診断 / 循環がん細胞 / 遊離核酸 / 無標識診断 / 病理組織 / 生体リアルタイム評価 / 生体リアルタイム診断 / 自動診断支援 / 人工知能 / 循環癌細胞 / 表面増強ラマン散乱 / バイオチップ / 分光法
Outline of Final Research Achievements

In Japan, the majority of causes of death is cancer. Early detection and rapid start of treatment are very important for improving cancer prognosis. However, there is an excellent system of cancer screening in Japan, we tried to detect circulating tumor cells and cell-free nucleic acids related to cancer in the blood for the purpose of further improving the accuracy of cancer diagnosis.
By using Raman scattering spectroscopy, it is possible to detect more cell-free nucleic acids and proteins related to cancer in the blood from the patients with gastric or colonic cancer than the patients without cancer.
Moreover, applying this spectroscopic method, we established the basic technology for evaluating cell biology without labeling.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (14 results)

All 2016 2015 2014 Other

All Journal Article (8 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 6 results,  Open Access: 3 results,  Acknowledgement Compliant: 3 results) Presentation (1 results) Remarks (1 results) Patent(Industrial Property Rights) (4 results)

  • [Journal Article] Long-term prognostic impact of circulating tumour cells in gastric cancer patients2016

    • Author(s)
      Hiroaki Ito, Jun Sato, Yukio Tsujino, Noriko Yamaguchi, Satoshi Kimura, Keigo Gohda, Katsuhiro Murakami, Manabu Onimaru, Tohru Ohmori, Fumihiro Ishikawa, and Haruhiro Inoue
    • Journal Title

      World Journal of Gastroenterology

      Volume: 22 Issue: 46 Pages: 10232-10241

    • DOI

      10.3748/wjg.v22.i46.10232

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Change of number and size of circulating tumor cells with high telomerase activity during treatment of patients with gastric cancer2016

    • Author(s)
      Hiroaki Ito, Noriko Yamaguchi, Manabu Onimaru, Satoshi Kimura, Tohru Ohmori, Fumihiro Ishikawa, Jun Sato, Shun Ito and Haruhiro Inoue
    • Journal Title

      Oncology Letters

      Volume: 12 Issue: 6 Pages: 4720-4726

    • DOI

      10.3892/ol.2016.5239

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] 【特集がん医療の新たな展開】循環がん細胞研究の最近の知見と将来展望2016

    • Author(s)
      伊藤 寛晃
    • Journal Title

      BIO INDUSTRY

      Volume: 35 Pages: 38-42

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Silver Nanoscale Hexagonal Column Chips for Detecting Cell-Free DNA and Circulating Nucleosomes in Cancer Patients2015

    • Author(s)
      H. Ito, K. Hasegawa, Y. Hasegawa, T. Nishimaki, K. Hosomichi, S. Kimura, M. Ooba, H. Yao, M. Onimaru, I. Inoue, H. Inoue
    • Journal Title

      Scientific Reports

      Volume: 5 Issue: 1 Pages: 10455-10455

    • DOI

      10.1038/srep10455

    • Related Report
      2015 Research-status Report 2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Novel methodology for the detection of circulating tumor cells in gastric cancer and cell-free nucleic acids in gastrointestinal malignancies2015

    • Author(s)
      Hiroaki Ito, Katsuyuki Hasegawa, Yuuki Hasegawa, Satoshi Kimura, Manabu Onimaru, Noriko Yamaguchi, Haruo Ikeda, Mitsuo Saito, and Haruhiro Inoue
    • Journal Title

      Science Letters Journal

      Volume: 4 Pages: 179-179

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] 特集2. がん診断法の最先端、3. 消化器癌の新たな診断技術開発の試み2015

    • Author(s)
      伊藤 寛晃, 井上 晴洋
    • Journal Title

      PET journal

      Volume: 29 Pages: 37-39

    • Related Report
      2014 Research-status Report
  • [Journal Article] Use of surface-enhanced Raman scattering for detection of cancer-related serum-constituents in gastrointestinal cancer patients2014

    • Author(s)
      Hiroaki Ito, Haruhiro Inoue, Katsuyuki Hasegawa, Yuuki Hasegawa, Takehiko Shimizu, Satoshi Kimura, Manabu Onimaru, Haruo Ikeda and Shin-ei Kudo
    • Journal Title

      Nanomedicine: Nanotechnology, Biology and Medicine

      Volume: 10 Issue: 3 Pages: 599-608

    • DOI

      10.1016/j.nano.2013.09.006

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Prognostic impact of the number of viable circulating cells with high telomerase activity in gastric cancer patients : A prospective study2014

    • Author(s)
      Hiroaki Ito, Haruhiro Inoue, Satoshi Kimura, Tohru Ohmori, Fumihiro Ishikawa, Keigo Gohda and Jun Sato
    • Journal Title

      Internatonal Journal of Oncology

      Volume: 45 (published online on) Issue: 1 Pages: 227-234

    • DOI

      10.3892/ijo.2014.2409

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] SIMPLE BLOOD TEST FOR DIAGNOSIS OF GASTROINTESTINAL AND PANCREAS CANCER USING SURFACEENHANCED RAMAN SCATTERING2015

    • Author(s)
      Hiroaki Ito, Katsuyuki Hasegawa, Yuuki Hasegawa, Satoshi Kimura, Manabu Onimaru, Tohru Ohmori, Haruo Ikeda, Mitsuo Saito, Yohei Kitamura, Chiaki Sato, Kuniyo Gomi, Satoshi Sakaue, Masayuki Isozaki, Masaaki Matsukawa, and Haruhiro Inoue
    • Organizer
      Gastrointestinal Cancers Symposium
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2015-01-15
    • Related Report
      2014 Research-status Report
  • [Remarks] 昭和大学 江東豊洲病院 消化器センター_研究・業績

    • URL

      http://www10.showa-u.ac.jp/~ddc-kt/Page_03_03_research.html

    • Related Report
      2014 Research-status Report
  • [Patent(Industrial Property Rights)] がん診断方法2016

    • Inventor(s)
      伊藤寛晃,他4名
    • Industrial Property Rights Holder
      昭和大学、他1名
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2016-076219
    • Filing Date
      2016-04-05
    • Related Report
      2016 Annual Research Report
  • [Patent(Industrial Property Rights)] がん診断装置2016

    • Inventor(s)
      伊藤寛晃,他4名
    • Industrial Property Rights Holder
      昭和大学、他1名
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2016-076222
    • Filing Date
      2016-04-05
    • Related Report
      2016 Annual Research Report
  • [Patent(Industrial Property Rights)] 特許権2016

    • Inventor(s)
      伊藤寛晃, 匹田宗彰,瀧優介,福武直樹,横山楓
    • Industrial Property Rights Holder
      伊藤寛晃, 匹田宗彰,瀧優介,福武直樹,横山楓
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2016-076222
    • Filing Date
      2016-04-05
    • Related Report
      2015 Research-status Report
  • [Patent(Industrial Property Rights)] 特許権2016

    • Inventor(s)
      伊藤寛晃, 匹田宗彰,瀧優介,福武直樹,横山楓
    • Industrial Property Rights Holder
      伊藤寛晃, 匹田宗彰,瀧優介,福武直樹,横山楓
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2016-076219
    • Filing Date
      2016-04-05
    • Related Report
      2015 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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