Cancer diagnosis by analysis of circulating tumor cells with high telomerase activity and cell-free DNA
Project/Area Number |
26460688
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Laboratory medicine
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Research Institution | Showa University |
Principal Investigator |
Ito Hiroaki 昭和大学, 医学部, 准教授 (70443447)
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Co-Investigator(Renkei-kenkyūsha) |
Haruhiro Inoue 昭和大学, 医学部, 教授 (90280966)
Satoshi Kimura 昭和大学, 医学部, 教授 (30255765)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2015: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | がん診断 / 循環がん細胞 / 遊離核酸 / 無標識診断 / 病理組織 / 生体リアルタイム評価 / 生体リアルタイム診断 / 自動診断支援 / 人工知能 / 循環癌細胞 / 表面増強ラマン散乱 / バイオチップ / 分光法 |
Outline of Final Research Achievements |
In Japan, the majority of causes of death is cancer. Early detection and rapid start of treatment are very important for improving cancer prognosis. However, there is an excellent system of cancer screening in Japan, we tried to detect circulating tumor cells and cell-free nucleic acids related to cancer in the blood for the purpose of further improving the accuracy of cancer diagnosis. By using Raman scattering spectroscopy, it is possible to detect more cell-free nucleic acids and proteins related to cancer in the blood from the patients with gastric or colonic cancer than the patients without cancer. Moreover, applying this spectroscopic method, we established the basic technology for evaluating cell biology without labeling.
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Report
(4 results)
Research Products
(14 results)
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[Journal Article] Long-term prognostic impact of circulating tumour cells in gastric cancer patients2016
Author(s)
Hiroaki Ito, Jun Sato, Yukio Tsujino, Noriko Yamaguchi, Satoshi Kimura, Keigo Gohda, Katsuhiro Murakami, Manabu Onimaru, Tohru Ohmori, Fumihiro Ishikawa, and Haruhiro Inoue
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Journal Title
World Journal of Gastroenterology
Volume: 22
Issue: 46
Pages: 10232-10241
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Silver Nanoscale Hexagonal Column Chips for Detecting Cell-Free DNA and Circulating Nucleosomes in Cancer Patients2015
Author(s)
H. Ito, K. Hasegawa, Y. Hasegawa, T. Nishimaki, K. Hosomichi, S. Kimura, M. Ooba, H. Yao, M. Onimaru, I. Inoue, H. Inoue
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Journal Title
Scientific Reports
Volume: 5
Issue: 1
Pages: 10455-10455
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] SIMPLE BLOOD TEST FOR DIAGNOSIS OF GASTROINTESTINAL AND PANCREAS CANCER USING SURFACEENHANCED RAMAN SCATTERING2015
Author(s)
Hiroaki Ito, Katsuyuki Hasegawa, Yuuki Hasegawa, Satoshi Kimura, Manabu Onimaru, Tohru Ohmori, Haruo Ikeda, Mitsuo Saito, Yohei Kitamura, Chiaki Sato, Kuniyo Gomi, Satoshi Sakaue, Masayuki Isozaki, Masaaki Matsukawa, and Haruhiro Inoue
Organizer
Gastrointestinal Cancers Symposium
Place of Presentation
San Francisco, USA
Year and Date
2015-01-15
Related Report
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[Patent(Industrial Property Rights)] 特許権2016
Inventor(s)
伊藤寛晃, 匹田宗彰,瀧優介,福武直樹,横山楓
Industrial Property Rights Holder
伊藤寛晃, 匹田宗彰,瀧優介,福武直樹,横山楓
Industrial Property Rights Type
特許
Industrial Property Number
2016-076222
Filing Date
2016-04-05
Related Report
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[Patent(Industrial Property Rights)] 特許権2016
Inventor(s)
伊藤寛晃, 匹田宗彰,瀧優介,福武直樹,横山楓
Industrial Property Rights Holder
伊藤寛晃, 匹田宗彰,瀧優介,福武直樹,横山楓
Industrial Property Rights Type
特許
Industrial Property Number
2016-076219
Filing Date
2016-04-05
Related Report