| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
Previously, I reported that loss of Cables expression is observed in several tumors and high expression of Cables induced apoptosis. From these findings, I hypothesized that Cables is getting increased in early stage of tumor and cause cell death to prevent tumor. Evidence of hyper methylation of the Cables promoter was also observed in several tumors.
These findings suggested that Cables expression in tumor may be regulated the promoter activity. To evaluate the Cables promoter regulation, I evaluated Cables promoter activity in endometrial tumor derived culture cell lines. Cells were stimulated by Progesterone, Phorbol12-Myristate13-acetate (PMA) or Forskolin. As result, Cables promoter activity has increased in one of cell lines by PMA which is an activator of protein kinase C (PKC). This result suggest that Cables promoter regulation is depends on the cell type. The PKC regulation to Cables promoter is not clear, however it is one of strong regulator of Cables promoter activity.
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