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Search for the molecules involved in leukemic transformation of myelodysplastic syndromes

Research Project

Project/Area Number 26460691
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Laboratory medicine
Research InstitutionKawasaki Medical School

Principal Investigator

TOHYAMA KAORU  川崎医科大学, 医学部, 教授 (80227561)

Co-Investigator(Renkei-kenkyūsha) TSUJIOKA Takayuki  川崎医科大学, 医学部, 講師 (50330551)
SUEMORI Shin-ichiro  川崎医科大学, 医学部, 講師 (60330552)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords網羅的遺伝子解析 / 腫瘍関連遺伝子 / 造血障害 / 白血病移行
Outline of Final Research Achievements

Myelodysplastic syndromes (MDS) often transform to acute myeloid leukemia, but its mechanisms remain almost uncertain. We utilized an MDS-derived cell line and various sublines together with the bone marrow sample from the original MDS patient, and performed whole exome sequencing of each cell line. Consequently, we found several important gene mutations such as CEBPA, NRAS, Histone1H3C (K27M) and TET2.
Now we are investigating the role of each gene mutation towards searching for the molecules involved in leukemic transformation of MDS.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (20 results)

All 2016 2015 2014 Other

All Journal Article (7 results) (of which Peer Reviewed: 6 results,  Open Access: 4 results,  Acknowledgement Compliant: 1 results) Presentation (7 results) (of which Invited: 7 results) Book (4 results) Remarks (2 results)

  • [Journal Article] Withaferin A suppresses the growth of myelodysplasia and leukemia cell lines by inhibiting cell cycle progression.2016

    • Author(s)
      Okamoto S, Tsujioka T, Suemori SI, Kida JI, Kondo T, Tohyama Y, Tohyama K
    • Journal Title

      Cancer Sci

      Volume: 107 Issue: 9 Pages: 1302-1314

    • DOI

      10.1111/cas.12988

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prognostic significance of Wilms tumor 1 mRNA expression levels in peripheral blood and bone marrow in patients with myelodysplastic syndromes.2016

    • Author(s)
      Kobayashi S, Ueda Y, Nannya Y, Shibayama H, Tamura H, Ogata K, Akatsuka Y, Usuki K, Ito Y, Okada M, Suzuki T, Hata T, Matsuda A, Tohyama K, et al.
    • Journal Title

      Cancer Biomarkers

      Volume: in press Issue: 1 Pages: 1-12

    • DOI

      10.3233/cbm-160612

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Five-aza-2'-deoxycytidine-induced hypomethylation of cholesterol 25-hydroxylase gene is responsible for cell death of myelodysplasia/leukemia cells.2015

    • Author(s)
      Tsujioka T, Yokoi A, Itano Y, Takahashi K, Ouchida M, Okamoto S, Kondo T, Suemori S, Tohyama Y, Tohyama K
    • Journal Title

      Scientific Reports

      Volume: 5 Issue: 1 Pages: 16709-16709

    • DOI

      10.1038/srep16709

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Rigosertib induces cell death of an MDS-derived cell line by DNA damage-induced G2/M arrest.2015

    • Author(s)
      Hyoda T, Tsujioka T, Tohyama K, et al.
    • Journal Title

      Cancer Science

      Volume: 106 Issue: 3 Pages: 287-293

    • DOI

      10.1111/cas.12605

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Arsenic disulfide-triggered apoptosis and erythroid differentiation in myelodysplastic syndrome and acute myeloid leukemia cell lines.2014

    • Author(s)
      Hu X-M, Tohyama K, et al.
    • Journal Title

      Hematology

      Volume: 19 Issue: 6 Pages: 352-360

    • DOI

      10.1179/1607845413y.0000000138

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Delayed false elevation of circulating tacrolimus concentrations after cord blood transplantation in a patient with myelodysplastic syndrome.2014

    • Author(s)
      Hayashi K, Tasaka T, Tohyama K, et al.
    • Journal Title

      Internal Medicine

      Volume: 53 Pages: 2635-2638

    • NAID

      130004713238

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] 骨髄異形成症候群の病態解明と診断の進歩.2014

    • Author(s)
      通山 薫
    • Journal Title

      最新医学

      Volume: 69 Pages: 2125-2133

    • Related Report
      2014 Research-status Report
  • [Presentation] 骨髄系腫瘍へのアプローチ---形態学の視点から2016

    • Author(s)
      通山 薫
    • Organizer
      第14回日本検査血液学会北海道支部総会
    • Place of Presentation
      札幌市(北海道大学医学部)
    • Year and Date
      2016-06-11
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] みんなで取り組もう、MDSの異形成判定2016

    • Author(s)
      通山 薫
    • Organizer
      日本検査血液学会 第14回冬季セミナー
    • Place of Presentation
      パレス松洲 (宮城)
    • Year and Date
      2016-02-27
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 血球形態から分かる骨髄系腫瘍の病態2015

    • Author(s)
      通山 薫
    • Organizer
      第19回ILYH(Interactive Lectures for Young Hematologist)研究会
    • Place of Presentation
      野村コンファレンスセンター新宿 (東京)
    • Year and Date
      2015-06-12
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 血液検査技師が知っておくべきMDS---血球の異形成の捉え方、考え方2015

    • Author(s)
      通山 薫
    • Organizer
      日本検査血液学会 第13回冬季セミナー
    • Place of Presentation
      クロスウェーブ幕張(千葉)
    • Year and Date
      2015-02-14
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] MDS 診断への道しるべ --- 形態とどのように付き合うか?2014

    • Author(s)
      通山 薫
    • Organizer
      平成26年度日本臨床衛生検査技師会 中部圏支部臨床血液部門研修会
    • Place of Presentation
      岐阜大学医学部(岐阜)
    • Year and Date
      2014-12-14
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 「造血器腫瘍の先端医療を支える臨床検査」:診断確定・病型分類のための血液検査・形態診断~骨髄異形成症候群.2014

    • Author(s)
      通山 薫
    • Organizer
      第61回日本臨床検査医学会学術集会
    • Place of Presentation
      福岡国際会議場(福岡)
    • Year and Date
      2014-11-25
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 形態異常からわかる病態2014

    • Author(s)
      通山 薫
    • Organizer
      第76回日本血液学会学術集会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Year and Date
      2014-10-31
    • Related Report
      2014 Research-status Report
    • Invited
  • [Book] 造血器腫瘍アトラス改訂第5版2016

    • Author(s)
      谷脇雅史、横田昇平、黒田純也 編著
    • Total Pages
      863
    • Publisher
      日本医事新報社
    • Related Report
      2016 Annual Research Report
  • [Book] ブラッシュアップ骨髄不全症2015

    • Author(s)
      通山 薫
    • Total Pages
      193
    • Publisher
      中外医学社
    • Related Report
      2015 Research-status Report
  • [Book] 最新ガイドライン準拠 血液疾患 診断・治療方針2015

    • Author(s)
      通山 薫
    • Total Pages
      560
    • Publisher
      中山書店
    • Related Report
      2015 Research-status Report
  • [Book] スタンダード検査血液学 第3版2014

    • Author(s)
      通山 薫
    • Total Pages
      460
    • Publisher
      医歯薬出版
    • Related Report
      2014 Research-status Report
  • [Remarks] 川崎医科大学検査診断学教室(病態解析学)ホームページ

    • URL

      http://www.kawasaki-m.ac.jp/lh/

    • Related Report
      2016 Annual Research Report
  • [Remarks] 川崎医科大学 検査診断学教室ホームページ

    • URL

      http://www.kawasaki-m.ac.jp/lh/

    • Related Report
      2015 Research-status Report 2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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